Atopic manifestations are more common in patients with Crohn disease than in the general population

Myrelid, Pär; Dufmats, Monika; Lilja, Ingela; Grännö, Christer; Lannerstad, O.; Sjödahl, Rune

doi:10.1080/00365520410005955

Cited by 22 publications

(32 citation statements)

References 35 publications

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“…Bernstein et al ( 8 ) analyzed over 8,000 IBD patients and found that asthma was the most common comorbidity in CD patients. The increased prevalence of atopic diseases, including eczema, asthma, and allergic rhinitis, was also reported in IBD ( 9 ). Specially, patients with IBD exhibit features resembling those of asthma, such as increased eosinophil counts in induced sputum and increased airway hyperresponsiveness, suggesting a close relationship between IBD and atopy and a shared tendency for mucosal inflammation in the lungs and gut ( 10 , 11 ).…”

Section: Introductionmentioning

confidence: 79%

Food-specific IgGs Are Highly Increased in the Sera of Patients with Inflammatory Bowel Disease and Are Clinically Relevant to the Pathogenesis

Xiao

Zhou

et al. 2018

Intern. Med.

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Objective Dietary antigens are common luminal antigens in the gastrointestinal tract and have been considered to contribute to the pathogenesis of inflammatory bowel disease (IBD). We analyzed the levels of food-specific IgGs against a variety of dietary antigens, explored the clinical relevance of food allergy to the pathogenesis of IBD, and investigated whether or not infliximab (IFX) treatment could regulate the immune responses induced by dietary antigens. Methods A total of 301 IBD patients, including 201 patients with Crohn's disease (CD) and 100 patients with ulcerative colitis (UC), were recruited, and their serum food-specific IgGs against 14 food antigens were detected by a semi-quantitative enzyme linked immunosorbent assay (ELISA). Total serum IgG and IgE levels were measured by immunonephelometry and ﬂuorescent enzyme immunoassay, respectively. Simultaneously, the relevant medical records and clinical data were collected for further analyses. Results Food-specific IgGs against egg, milk, wheat, corn, rice, tomato, codfish, and soybean antigens were found to be significantly increased in the sera of CD patients compared with UC patients and healthy controls (p<0.01). The levels of total serum IgG and IgE were also significantly higher in CD patients than in healthy controls (p<0.01). The titers of corn- and tomato-specific IgGs were found to be significantly correlated with total serum IgG in CD patients (p<0.05), while the titers of egg-, milk-, and wheat-specific IgGs were correlated with total serum IgE (p<0.05). Interestingly, IFX therapy was able to down-regulate the food-specific IgG-mediated immune response markedly in active CD patients. Conclusion Food-specific IgGs against egg, milk, wheat, corn, rice, tomato, codfish, and soybean are highly increased in the sera of CD patients. IFX treatment was able to down-regulate the levels of food-specific IgGs by suppressing intestinal inflammation and promoting mucosal healing. Therefore, food-specific IgGs may serve as an important approach in the diagnosis and management of food allergy in IBD.

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Section: Introductionmentioning

confidence: 79%

Food-specific IgGs Are Highly Increased in the Sera of Patients with Inflammatory Bowel Disease and Are Clinically Relevant to the Pathogenesis

Xiao

Zhou

et al. 2018

Intern. Med.

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“…Asthma before IBD 2. Asthma diagnosed before or after IBD CD, UC Age, sex, rural/urban residence, socioeconomic status Children and adults IBD: 5464 Controls: 402,800 Livnat 45 Israel Case-control Tertiary-care center (2008–2009 b ) Standard diagnostic criteria Self-report Not specified CD None Children and young adults IBD: 23 Controls: 24 Myrelid 46 Sweden Matched case-control Cases: Unclear controls: Southeastern Region Population Registry (2000) Standard diagnostic criteria Self-report Not specified CD Age, gender, place of residence, and other atopic manifestations (allergic rhinitis, eczema) Range: 18 to 50 years IBD: 275 Controls: 777 Nakamura 30 Japan Matched case-control Cases: Patients receiving financial aid from the Japanese government for the treatment of UC (1988–1990) Controls: Patients on the roster of a health check-up program Diagnosis of UC by treating physician, and confirmation of diagnosis by independent group for approval of financial aid Self-report questionnaire Asthma before IBD UC Matched on age and sex Children and adults IBD: 384 Controls: 384 Neilly 47 Scotland Matched case-control Not specified Not specified Previous physician-diagnosed asthma and/or history of persistent or episodic wheeze with breathlessness, responsive to bronchodilator therapy Not specified CD Matched on age, sex, and smoking history Adults IBD: 29 Controls: 29 Peng 29 Taiwan Frequency matched retrospective cohort National health administrative data (2000–2011) ICD codes for IBD ICD code for asthma and treated with inhaled corticosteroids, systemic corticosteroids, or inhaled short-acting ß2 agonists Asthma diagnosed after IBD CD, UC Frequency matched on age, sex, and index year. A...…”

Section: Resultsmentioning

confidence: 99%

“…IBD has also been associated with other respiratory disorders (e.g., chronic obstructive pulmonary disease) 42 , 54 . Further, both asthma and IBD have been associated with other immune-mediated and atopic conditions, including multiple sclerosis, rheumatoid arthritis, diabetes, eczema, and rhinitis 28 , 44 , 46 , 48 , 55 – 59 . However, there was a high degree of heterogeneity between studies, suggesting that the association between asthma and IBD may vary across populations and be impacted by differences in study methodology.…”

Section: Discussionmentioning

confidence: 99%

“…The following individuals were members of the CrowdScreen SR Review Team and participated in the review of abstracts and full-text: Jessica Bui; Adrijana D’Silva; Kainat Bashir, Jeanette Cheng, Yi Tong, Zhuo Qian (George) Cao, Matthew Peacock, Melissa Phuong; Melissa Wan; Meng Yang (Sunny) Xia; and Hsin Yun Yang. The authors would like to thank Pär Myrelid for providing additional data to enable the inclusion of Myrelid et al in the meta-analysis 46 and Nima Hamidi for translating Sharifpour et al 66 (excluded).…”

Section: Acknowledgementsmentioning

confidence: 99%

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Co-occurrence of Asthma and the Inflammatory Bowel Diseases: A Systematic Review and Meta-analysis

Kuenzig

Bishay

Leigh

et al. 2018

Clinical and Translational Gastroenterology

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BackgroundInflammatory bowel diseases (IBD) and asthma share genetic and environmental risk factors. Consequently, several observational studies have explored an association between IBD and asthma. We systematically reviewed and summarized the literature on the co-occurrence of asthma and IBD.MethodsMEDLINE and EMBASE (to April 2017) were searched to identify observational studies on the association between asthma and IBD. Relative risks (RR) were pooled using random effects models. Heterogeneity was assessed using the I2 and Cochran Q statistics. Meta-regression based on study design, source of patients (population-based vs. tertiary-care center) and study location was conducted to explain between-study heterogeneity.ResultsEighteen studies were identified (15 Crohn’s disease, 15 ulcerative colitis (UC)). Asthma was associated with both Crohn’s disease (pooled RR 1.30, 95% confidence interval (CI) 1.16–1.47, I2 = 88%) and UC (RR 1.34, 95% CI 1.24–1.44, I2 = 93%). The study design and source of patients and study location explained between-study heterogeneity in Crohn’s disease, but not UC.ConclusionAsthma is associated with both Crohn’s disease and UC. Additional research is needed to determine if one disease influences the risk of developing the other or if the frequent co-occurrence of these diseases result from shared genetic, environmental, and microbial risk factors.

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“…In large cohort studies, AD has also been recently associated with a variety of systemic diseases including inflammatory bowel disease [ 95 , 96 ], Type 1 Diabetes Mellitus [ 97 ], and ADHD [ 98 ], providing further evidence for its systemic nature. Additionally, AD, like psoriasis, was recently shown to be associated with increased vascular inflammation using CT imaging [ 99 – 101 ].…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis derived atopic dermatitis (MADAD) transcriptome defines a robust AD signature highlighting the involvement of atherosclerosis and lipid metabolism pathways

et al. 2015

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BackgroundAtopic dermatitis (AD) is a common inflammatory skin disease with limited treatment options. Several microarray experiments have been conducted on lesional/LS and non-lesional/NL AD skin to develop a genomic disease phenotype. Although these experiments have shed light on disease pathology, inter-study comparisons reveal large differences in resulting sets of differentially expressed genes (DEGs), limiting the utility of direct comparisons across studies.MethodsWe carried out a meta-analysis combining 4 published AD datasets to define a robust disease profile, termed meta-analysis derived AD (MADAD) transcriptome.ResultsThis transcriptome enriches key AD pathways more than the individual studies, and associates AD with novel pathways, such as atherosclerosis signaling (IL-37, selectin E/SELE). We identified wide lipid abnormalities and, for the first time in vivo, correlated Th2 immune activation with downregulation of key epidermal lipids (FA2H, FAR2, ELOVL3), emphasizing the role of cytokines on the barrier disruption in AD. Key AD “classifier genes” discriminate lesional from nonlesional skin, and may evaluate therapeutic responses.ConclusionsOur meta-analysis provides novel and powerful insights into AD disease pathology, and reinforces the concept of AD as a systemic disease.Electronic supplementary materialThe online version of this article (doi:10.1186/s12920-015-0133-x) contains supplementary material, which is available to authorized users.

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Atopic manifestations are more common in patients with Crohn disease than in the general population

Cited by 22 publications

References 35 publications

Food-specific IgGs Are Highly Increased in the Sera of Patients with Inflammatory Bowel Disease and Are Clinically Relevant to the Pathogenesis

Food-specific IgGs Are Highly Increased in the Sera of Patients with Inflammatory Bowel Disease and Are Clinically Relevant to the Pathogenesis

Co-occurrence of Asthma and the Inflammatory Bowel Diseases: A Systematic Review and Meta-analysis

Meta-analysis derived atopic dermatitis (MADAD) transcriptome defines a robust AD signature highlighting the involvement of atherosclerosis and lipid metabolism pathways

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