Atopic Keratoconjunctivitis in Children: Clinical Features and Diagnosis

Brémond‐Gignac, Dominique; Nischal, Ken K.; Mortemousque, B.; Gajdošová, Eva; Granet, David B.; Chiambaretta, Frédéric

doi:10.1016/j.ophtha.2015.07.012

Cited by 27 publications

(23 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Brémond-Gignac reported the largest series of pediatric AKC, which included 23 patients. 12 Most clinical features in that case series overlapped with those of VKC, 12 as documented in our case. The presence of AKC-related clinical features but an absence of VKC-related clinical features in combination with a history of eczema and conjunctivitis and/or keratitis may secure an accurate diagnosis of AKC in children.…”

Section: Figuresupporting

confidence: 71%

“…11 In 2015, Brémond-Gignac proposed the diagnostic criterion of pediatric AKC as the presence of severe allergic conjunctivitis with AD that is diagnosed before 16 years of age. 12 VKC is another rare but severe type of allergic conjunctivitis that may involve the cornea. Severe itching and cobblestone papillae are the most significant characteristics of VKC, and thus have diagnostic value.…”

Section: Figurementioning

confidence: 99%

“…The presence of AKC-related clinical features but an absence of VKC-related clinical features in combination with a history of eczema and conjunctivitis and/or keratitis may secure an accurate diagnosis of AKC in children. 12 However, if a pediatric patient presents with typical clinical features of VKC, distinguishing AKC from VKC is challenging. For example, our patient had ocular redness and itching, conjunctival injection, cobblestone papillae on the conjunctiva of the upper lid, and a shield ulcer, which are the typical manifestations of VKC and explain why the patient had been previously misdiagnosed as having VKC.…”

Section: Figurementioning

confidence: 99%

See 2 more Smart Citations

Recalcitrant Atopic Keratoconjunctivitis in Children: A Case Report and Literature Review

Luo

et al. 2018

Pediatrics

View full text Add to dashboard Cite

Atopic keratoconjunctivitis (AKC) is the most severe type of allergic conjunctivitis and may eventually lead to blindness. Although AKC is reported to be more prevalent in adults, we report a child with AKC whose clinical characteristics were not inconsistent with those typically seen in adult patients with AKC, and who was refractory to traditional topical anti-inflammatory and immunosuppressant therapies. An 11-year-old boy presented with a 3-month history of ocular redness and itching and decreased vision for a week in both eyes. Slit-lamp examination revealed typical signs of vernal keratoconjunctivitis, including cobblestone papillae in both upper conjunctiva, superficial punctate keratopathy on the right cornea, and a sterile shield-shaped ulcer on the left cornea. Physical examination revealed eczematous lid changes and a generalized body rash, particularly on the face, neck, and flexor surfaces of the limbs. He was diagnosed to have AKC in both eyes and atopic dermatitis. The patient did not respond well to conventional topical antihistamine, mast cell stabilizers, corticosteroids, or tacrolimus, even in combination with amniotic membrane transplant. After using systemic immunosuppressants, the symptoms were relieved; the inflammation on the skin and ocular surface subsided, the cobblestone papillae disappeared, and the corneal ulcer healed gradually within 8 weeks. This case reveals that pediatric AKC should be differentiated from vernal keratoconjunctivitis because both disorders include upper cobblestone papillae, but the former is accompanied by atopic dermatitis. Pediatric AKC requires appropriate and aggressive treatment to prevent sight-threatening corneal complications. Systemic immunosuppressant should be considered when traditional topical anti-inflammatory therapies have failed.

show abstract

Section: Figuresupporting

confidence: 71%

Section: Figurementioning

confidence: 99%

Section: Figurementioning

confidence: 99%

See 1 more Smart Citation

Recalcitrant Atopic Keratoconjunctivitis in Children: A Case Report and Literature Review

Luo

et al. 2018

Pediatrics

View full text Add to dashboard Cite

show abstract

“…A French study concluded that all young, allergic boys with eye-rubbing tendencies and a recent onset of corneal astigmatism should be examined regularly in order for keratoconus to be detected at an early stage [64]. Studies demonstrating the relationship between AD and cataract in young individuals have also been published [65,66].The most frequent symptoms of AKC in paedi-atric patients with atopy are conjunctival hyperemia and eczema (96%) [67].…”

Section: Childrenmentioning

confidence: 99%

Ophthalmic manifestations of atopic dermatitis

Pietruszyńska¹,

Zawadzka-Krajewska²,

Duda³

et al. 2020

pdia

View full text Add to dashboard Cite

Atopic dermatitis is a chronic condition of complex etiology, whose clinical course involves remission and recurrence. It is not an isolated disease entity affecting only the skin, but one that co-occurs with disorders of other organs. Numerous literature reports have long confirmed the relationship between the disorder and a growing number of ophthalmic manifestations such as keratoconus and retinal detachment. Further studies are required to establish the cause of correlations and to allow for implementation of appropriate prophylaxis and treatment. The aim of the present paper is to review published literature regarding the correlation between atopic dermatitis and ophthalmic manifestations in adults and children.

show abstract

“…A CCA tem inicio tradicionalmente no final da adolescência e inicio da vida adulta, (51) embora tenham sido descritos vários casos em crianças. (52) Entre as demais conjuntivites alérgicas, a CCA tem maior gravidade pois acomete progressivamente a conjuntiva e a córnea dos pacientes, podendo persistir por toda a vida, representando uma potencial causa de cegueira nesse grupo. (37)…”

Section: Introductionunclassified

Análise da expressão das proteínas de barreira epitelial, filagrina e claudina-1, na superfície ocular de pacientes portadores de dermatite atópica

Callou¹

View full text Add to dashboard Cite

Análise da expressão das proteínas de barreira epitelial, filagrina e claudina-1, na superfície ocular de pacientes portadores de dermatite atópica São Paulo 2019 Tese apresentada à Faculdade de Medicina da Universidade de São Paulo para obtenção do título em doutor em Ciências Programa de Oftalmologia Orientador: Profa. Dra. Ruth Miyuki Santo Co-orientador: Profa. Dra. Monique Matsuda Dedicatória DedicatóriaAos meus pais José Lívio e Bida, pelo amor incondicional, pelo apoio incessante a minha carreira profissional, por serem meus maiores exemplos de dedicação e firmeza de caráter e a quem serei eternamente grata.Ao meu esposo Bruno, que esteve ao meu lado em todas as etapas da construção desta tese e representou minha fortaleza nas partes mais árduas; com quem pude dividir aprendizados e de quem sempre recebi carinho, compreensão e estímulo.Ao meu filho Bernardo, que faz brotar em mim diariamente um desejo cada vez maior de crescer como ser humano e como profissional.Aos meus irmãos Clarice, Eduardo e Romero, pela certeza de que juntos somos mais fortes, por serem pilares na minha vida.Aos meus tios José Luiz e Amélia e as minhas primas Natália, Alexandra e Rosa, que vibraram com cada conquista e que significaram um porto seguro na minha trajetória em São Paulo.Ao meu avô Antônio Lyrio Callou (in memorian), que me deixou o grande legado de ingressar na carreira acadêmica.

show abstract

Atopic Keratoconjunctivitis in Children: Clinical Features and Diagnosis

Abstract: International audienceno abstrac

Cited by 27 publications

References 7 publications

Recalcitrant Atopic Keratoconjunctivitis in Children: A Case Report and Literature Review

Recalcitrant Atopic Keratoconjunctivitis in Children: A Case Report and Literature Review

Ophthalmic manifestations of atopic dermatitis

Análise da expressão das proteínas de barreira epitelial, filagrina e claudina-1, na superfície ocular de pacientes portadores de dermatite atópica

Contact Info

Product

Resources

About