Atopic eczema and the home environment

McNally, Nick; Williams, Hywel C; Phillips, David

doi:10.1046/j.1365-2133.2001.04474.x

Cited by 74 publications

(52 citation statements)

References 30 publications

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“…The association between mold and AD was reported in previous studies. Several studies have reported a positive association between mold and AD [23,24,25,26]; another study in Germany suggested mold is not related with atopic eczema [27]. Sick building syndrome is a syndrome associated with an individual’s place of work or residence.…”

Section: Discussionmentioning

confidence: 99%

Exposure to Gene-Environment Interactions before 1 Year of Age May Favor the Development of Atopic Dermatitis

Lee¹,

Seo²,

Kwon

et al. 2011

Int Arch Allergy Immunol

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Background: The aims of this study were to determine (1) the prevalence of atopic dermatitis (AD) in Seoul, Korea, and (2) the influence of environmental and genetic factors on disease risk. Methods: A questionnaire survey was conducted in 5,036 primary school children and 4,607 middle school children in 2008. For each child, a modified version of the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire and a questionnaire assessing exposure to environmental variables were completed. Results: In primary school children, the lifetime prevalence of itchy eczema was 24.3%, the 12-month prevalence of itchy flexural eczema was 18.0%, the lifetime prevalence of AD diagnosis was 31.3%, and the 12-month prevalence of AD treatment was 14.5%. In middle school children, the corresponding rates were 16.0, 10.8, 22.1, and 8.3%, respectively. These rates are significantly higher than those reported in similar studies conducted in 1995 and 2000. In both primary and middle school children, a parental history of allergic disease and a history of having moved into a newly built house before 1 year of age were independently associated with a risk for current AD. For current AD, the prevalence odds ratio was higher in the subgroup with both a genetic and a specific environmental risk factor than in the subgroup with no risk factor or subgroups with only one risk factor. Conclusions: The prevalence of AD in primary and middle school children in Seoul has increased. Its development may be influenced by gene-environment interactions, particularly before 1 year of age.

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Section: Discussionmentioning

confidence: 99%

Exposure to Gene-Environment Interactions before 1 Year of Age May Favor the Development of Atopic Dermatitis

Lee¹,

Seo²,

Kwon

et al. 2011

Int Arch Allergy Immunol

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show abstract

“…There are many factors demonstrated to be associated with AD: personal factors (e.g., smoking habits, age, gender, nutritional status, number of siblings, lifestyle, allergy status, family history and occupation) [2] and indoor/outdoor environmental factors (e.g., house dust mite, animal dander, molds, cockroach infestation, occupational exposure, environmental tobacco smoke (ETS), air pollution, aeroallergens and climate) [3,4,5]. Many reports on indoor/outdoor environment in relation to AD were from Western populations [2,3,4,5,6] and little information on environmental risk factors associated with AD in Chinese children is available.…”

Section: Introductionmentioning

confidence: 99%

Residential Risk Factors for Atopic Dermatitis in 3- to 6-Year Old Children: A Cross-Sectional Study in Shanghai, China

Yan

Zheng

et al. 2016

IJERPH

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Background: Atopic dermatitis (AD) is common among pre-school children in Shanghai. This study aimed to identify the risk factors for childhood AD from the perspectives of home environment, demographics and parents-grandparents’ atopic disease. Methods: A cross-sectional study was conducted in Shanghai in April–June, 2010. Preschool children’s parents or guardians were invited to participate a questionnaire survey in six districts (two urban and four suburban/rural) and 6624 children were finally recruited (51.3% boys). AD diagnosis was based on the U.K. Working Party’s (UKWP) criteria. Adjusted odds ratios (AOR) with 95% confidence intervals (95% CI) were calculated by multiple logistic regression. Results: A total of 8.5% of children ever had AD. Around 10.2% of the mothers had lived in newly renovated/decorated homes (NRDH) during the prenatal period (one year before or during pregnancy) and 9.5% got new home furniture (NHF) during the same period. AD was more common in children when mothers had lived in NRDH homes during the prenatal period (AOR = 1.41; 95% CI 1.03–1.93), the current home had indoor mold (2.00, 1.48–2.70), parents-grandparents’ had atopic diseases (3.85, 3.05–4.87), the children had food allergy (3.40, 2.63–4.40) or children lived in urban area (1.52, 1.18–1.96). Associations between AD and NRDH, NHF and indoor molds were only significant in children without parents-grandparents’ atopic diseases. There was an interaction effect between parents-grandparents’ atopic diseases and NRDH (p < 0.05). Conclusions: Home renovation/ redecoration, new furniture and indoor mold, urban residency, heredity disposition and food allergy can be risk factors for childhood AD in Shanghai.

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“…[19][20][21][22][23][24][25][26][27] However, there are few formal longitudinal studies that indicate how the home environment has changed over the past 50 years. We previously reviewed data regarding exposure to soap detergents, frequency of washing, and exposure to house dust mites.…”

mentioning

confidence: 99%

New perspectives on epidermal barrier dysfunction in atopic dermatitis: Gene–environment interactions

Cork

Robinson

Vasilopoulos

et al. 2006

Journal of Allergy and Clinical Immunology

461

335

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Atopic eczema and the home environment

Abstract: Further research is needed to confirm these associations and additional research is needed to see whether they might be causative. Practical public health advice about the importance of controlling the home environment may then be targeted at families with atopic eczema.

Cited by 74 publications

References 30 publications

Exposure to Gene-Environment Interactions before 1 Year of Age May Favor the Development of Atopic Dermatitis

Exposure to Gene-Environment Interactions before 1 Year of Age May Favor the Development of Atopic Dermatitis

Residential Risk Factors for Atopic Dermatitis in 3- to 6-Year Old Children: A Cross-Sectional Study in Shanghai, China

New perspectives on epidermal barrier dysfunction in atopic dermatitis: Gene–environment interactions

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