Atopic eczema and indoor climate: results from the children from Lübeck allergy and environment study (KLAUS)

Schäfer, Torsten; Stieger, Björn; Polzius, R.; Krauspe, Anja

doi:10.1111/j.1398-9995.2007.01573.x

Cited by 24 publications

(12 citation statements)

References 15 publications

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“…House dust mite allergen is a well-known contributor to the etiol-ogy of atopic eczema. A high mite allergen level was significantly associated with an increased risk of atopic eczema among children in Japan [25] and in Germany [24]. Therefore, avoiding humid indoor climate might reduce the prevalence of atopic eczema.…”

Section: Discussionmentioning

confidence: 99%

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Effects of home environment and lifestyles on prevalence of atopic eczema among children in Wuhan area of China

Zhang

Yuan

et al. 2013

Chin. Sci. Bull.

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Section: Discussionmentioning

confidence: 99%

“…Indoor high humidity may provide a suitable climate for dust mite propagation. A German study found that the prevalence of signs of moisture problems correlated significantly with the measured exposure to house dust mite allergens [24]. House dust mite allergen is a well-known contributor to the etiol-ogy of atopic eczema.…”

Section: Discussionmentioning

confidence: 99%

Effects of home environment and lifestyles on prevalence of atopic eczema among children in Wuhan area of China

Zhang

Yuan

et al. 2013

Chin. Sci. Bull.

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“…The association between mold and AD was reported in previous studies. Several studies have reported a positive association between mold and AD [23,24,25,26]; another study in Germany suggested mold is not related with atopic eczema [27]. Sick building syndrome is a syndrome associated with an individual’s place of work or residence.…”

Section: Discussionmentioning

confidence: 99%

Exposure to Gene-Environment Interactions before 1 Year of Age May Favor the Development of Atopic Dermatitis

Lee¹,

Seo²,

Kwon

et al. 2011

Int Arch Allergy Immunol

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Background: The aims of this study were to determine (1) the prevalence of atopic dermatitis (AD) in Seoul, Korea, and (2) the influence of environmental and genetic factors on disease risk. Methods: A questionnaire survey was conducted in 5,036 primary school children and 4,607 middle school children in 2008. For each child, a modified version of the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire and a questionnaire assessing exposure to environmental variables were completed. Results: In primary school children, the lifetime prevalence of itchy eczema was 24.3%, the 12-month prevalence of itchy flexural eczema was 18.0%, the lifetime prevalence of AD diagnosis was 31.3%, and the 12-month prevalence of AD treatment was 14.5%. In middle school children, the corresponding rates were 16.0, 10.8, 22.1, and 8.3%, respectively. These rates are significantly higher than those reported in similar studies conducted in 1995 and 2000. In both primary and middle school children, a parental history of allergic disease and a history of having moved into a newly built house before 1 year of age were independently associated with a risk for current AD. For current AD, the prevalence odds ratio was higher in the subgroup with both a genetic and a specific environmental risk factor than in the subgroup with no risk factor or subgroups with only one risk factor. Conclusions: The prevalence of AD in primary and middle school children in Seoul has increased. Its development may be influenced by gene-environment interactions, particularly before 1 year of age.

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“…2,3 Among environmental factors, house dust mite (HDM) allergens are important for the development of AD as well as asthma and rhinitis. [4][5][6] Dermatophagoides pteronyssinus and Dermatophagoides farinae are the most common types of HDM in temperate climates and are known to contribute to the immunopathogenesis of AD through the induction of IgE binding. 7 In airway allergy, activation of innate immunity by HDM allergens plays an important role in disease pathogenesis.…”

mentioning

confidence: 99%

Mite allergen is a danger signal for the skin via activation of inflammasome in keratinocytes

Dai¹,

Sayama²,

Tohyama³

et al. 2011

Journal of Allergy and Clinical Immunology

137

112

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Atopic eczema and indoor climate: results from the children from Lübeck allergy and environment study (KLAUS)

Cited by 24 publications

References 15 publications

Effects of home environment and lifestyles on prevalence of atopic eczema among children in Wuhan area of China

Effects of home environment and lifestyles on prevalence of atopic eczema among children in Wuhan area of China

Exposure to Gene-Environment Interactions before 1 Year of Age May Favor the Development of Atopic Dermatitis

Mite allergen is a danger signal for the skin via activation of inflammasome in keratinocytes

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