Atopic dermatitis-mitigating effects of newLactobacillusstrain,Lactobacillus sakeiprobio 65 isolated from Kimchi

Abstract

Aims: Atopic dermatitis (AD) is an inflammatory skin disease. Probiotics have been reported to modulate immune responses and thus are now being suggested as potential treatments for allergies. In this study, we investigated the inhibitory effects of Lactobacillus sakei probio 65 isolated from Kimchi on artificially inducing AD in NC/Nga mice. Methods and Results: Oral administration of viable or heat-inactivated Lact. sakei probio 65 improved the condition of skin and reduced scratching frequency. Serum levels of IgE and cutaneous T-cell-attracting chemokine (CTACK) were significantly decreased by this therapy. Dead Lact. sakei probio 65 also decreased IL-4 and IL-6 serum concentrations. Moreover, both live and dead Lact. sakei probio 65 inhibited the expression of Thymus and activationregulated chemokine and CTACK in AD-like skin lesions. The increased levels of Foxp3 expression in the lesional skin and ears were also suppressed by Lact. sakei probio 65. In addition, Lact. sakei probio 65 inhibited b-hexosaminidase release and the secretion of IL-4, TNF-a and IL-6 from RBL-2H3 cells. Conclusions: Oral treatment with both viable and heat-inactivated Lact. sakei probio 65 inhibits skin inflammation and AD-like skin lesions, as well as mast cell activation. Significance and Impact of the Study: Lactobacillus sakei probio 65 has an inhibitory effect on atopic dermatitis-like skin lesions and may represent an effective new anti-inflammatory agent.

Preventative and Therapeutic Probiotic Use in Allergic Skin Conditions: Experimental and Clinical Findings

“…In another study, Lctbs plantarum strains from Kimchi were investigated for their capacity to inhibit AD (house dust mite-induced dermatitis) in NC/Nga mouse. The three strains, CJLP55, CJLP133, and CJLP136, suppressed AD-like skin lesions and epidermal thickening [13, 23, 87]. …”

Pyrosequencing analysis of microbiota reveals that lactic acid bacteria are dominant in Korean flat fish fermented food,gajami-sikhae

“…Numerous studies have provided evidence that kimchi contains many beneficial probiotics, including that from LAB species. [43][44][45][46][47] In accordance with this, L. plantarum LG42 isolated from gajami-sikhae showed probiotic effects including anti-obesity properties. 7,11) A strain of L. sakei isolated from another food had been evaluated for its probiotic potential such as gastric resistance, survival, and bacteriocin production in the presence of bile salts and commercial prebiotics, and reducing the adhesion of Listeria monocytogenes to intestinal epithelial cells.…”

Lactobacillus reuteri DSM 17938—A comparative study on the effect of probiotics and lysates on human skin

“…There is a strong evidence for the potential use of orally administered probiotics (including L. reuteri ) in skin health, but the exact mechanisms are not well understood. Recently, researchers have begun to investigate the effect of probiotics and also lysates thereof, so‐called postbiotics topically on human skin .…”

“…In most cases, due to formulation challenges, much research has been performed using probiotic lysates (postbiotics) (mechanical, chemical or heat‐killed bacteria) with positive results . However now, with more data and information available on how bacteria can influence the skin in health and disease, there has been increased research activities on topical live products particularly in the areas of sensitive skin and more complex skin disorders such as acne and atopic dermatitis (AD) …”