Atopic dermatitis in adults: clinical and epidemiological considerations

Orfali, Raquel Leão; Shimizu, Marta M.; Takaoka, Roberto; Zaniboni, Mariana Colombini; Ishizaki, Aline S.; Costa, Anderson Alves; Tiba, Ana Paula L.; Sato, Maria Notomi; Aoki, Valéria

doi:10.1016/j.ramb.2012.12.004

Cited by 23 publications

(15 citation statements)

References 32 publications

(39 reference statements)

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“…This finding is consistent with previous reports that AD is one of the most common skin diseases, with a prevalence of 1% to 3% in adults [22,23]. In previous population-based studies, the prevalence of AD was 1.2% in Korean males aged around 20 years, whereas the prevalence of AD among adolescents aged 12–18 years was 22.4% [24,25].…”

Section: Discussionsupporting

confidence: 92%

Association of Perceived Stress with Atopic Dermatitis in Adults: A Population-Based Study in Korea

Park

Kim

2016

IJERPH

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Atopic dermatitis (AD) is a widely prevalent skin disease that affects both children and adults. The aim of the study was to assess the association of perceived stress (single-item, self-reported) with AD (self-reported) in a sample of Korean adults using a cross-sectional research design. A cross-sectional study was conducted using data from 33,018 adults aged 20 years and older collected in the 2007–2012 Korea National Health and Nutrition Examination Surveys (KNHANES). An increased level of self-reported stress was positively associated with an increased prevalence of AD in Korean adults (p for trend <0.001). After adjusting for covariates, the odds ratios (ORs) of AD among participants reporting high and very high levels of stress were 1.81 (95% confidence interval (CI): 1.22, 2.67) and 2.17 (95% CI: 1.38, 3.42), respectively, compared with those who reported low levels of stress. This study found a statistically significant association between perceived stress and AD among Korean adults.

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Section: Discussionsupporting

confidence: 92%

Association of Perceived Stress with Atopic Dermatitis in Adults: A Population-Based Study in Korea

Park

Kim

2016

IJERPH

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“…Most of the infants had mild to moderate severity; however, the EASI score increased with age, reaching >30% of that of severe adult patients. As in previous studies, the severity was either mild or moderate in >80% of the infants and children,1518 whereas a higher percentage (25%-31%) of patients in their adulthood had severe AD 734. Some other studies, however, showed contradictory data, with only 1.7% of adult patients having severe AD 19.…”

Section: Discussionmentioning

confidence: 60%

Clinical Diversity of Atopic Dermatitis: A Review of 5,000 Patients at a Single Institute

Chu

Shin

Park

et al. 2017

Allergy Asthma Immunol Res

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PurposeAtopic dermatitis (AD) is a chronic eczematous dermatitis that has a high prevalence and diverse clinical features. Although several hypotheses about its multifactorial pathogenesis have been suggested, the cause is not yet fully understood. A better understanding of the clinical features may helpful inelucidating the pathogenesis of AD.MethodsThis retrospective study analyzed the questionnaires, medical charts, and laboratory examination results of 5,000 patients diagnosed with AD at a single tertiary hospital in Korea.ResultsThe demographics, allergic comorbidities, family history, severity, and treatment experiences of the patients were analyzed. Most of the patients were adults, 76.3% of whom were classified as havingan extrinsic type of AD. The mean eczema area and severity index (EASI) score was found to be 13.68, and adult patients were found to have higher severity than the other age groups. The anatomical involvements were different among the age groups, with more involvements of the head and neck in adults. The patients reported seasonal changes and stress as the factors that aggravated their symptoms the most. Topical steroids and oral cyclosporine were the most used medications at our clinic, whereas 10.1% of the patients underwent allergen-specific immunotherapy.ConclusionsThis analysis of 5,000 patients would lead to a better understanding of various subtypes and diverse clinical features of AD in Koreans. Distinct characteristics were observed among different age groups; thus, treatment strategies may need to be differentiated accordingly.

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“…We also determined the effects of dupilumab on the serum levels of total IgE (normal range, ≤170 IU/ml) during the course of dupilumab treatment, based on the reported association of the total IgE level with the long-term response to treatment in AD patients. [19][20][21][22][23] Total IgE levels were measured in 7, 10, 13, 15, 9, and 5 of the 40 patients at 2, 4, 8, 16, 24, and 32 weeks after the start of dupilumab administration, respectively ( Fig. 3c and Table 5).…”

Section: Effects Of Dupilumab On Serum Levels Of Total Igementioning

confidence: 99%

Dupilumab treatment ameliorates clinical and hematological symptoms, including blood eosinophilia, in patients with atopic dermatitis

et al. 2020

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Background Atopic dermatitis (AD) is an allergic disease that affects individuals of various ages. Recently, the IL‐4/13 inhibitor dupilumab has gained regulatory approval for clinical use in AD patients. Dupilumab has been reported to reduce several markers of AD, including the serum levels of thymus and activation‐regulated chemokine (TARC/CCL17), blood lactate dehydrogenase (LDH), and serum total immunoglobulin E (IgE). Methods We retrospectively reviewed data from 40 AD patients who were treated with dupilumab. Eczema Area and Severity Index (EASI), Investigator’s Global Assessment (IGA), body surface area (BSA) scores, TARC, LDH, total IgE, and eosinophil count in peripheral blood were assessed for a total of 32 weeks. Results The EASI, IGA, and BSA scores improved significantly with treatment, indicating a reduction in AD severity. Serum TARC and LDH levels also significantly decreased with treatment. Serum IgE levels were unchanged at 2 weeks of treatment but decreased significantly between 4 and 32 weeks. The number of eosinophils in the peripheral blood decreased at 4, 16, and 32 weeks after treatment initiation. Conclusions Several studies have reported that serum TARC, LDH, and total IgE levels are reduced by dupilumab treatment. Our real‐world data are the first to demonstrate a reduction in blood eosinophilia in patients who receive clinical treatment with dupilumab.

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Atopic dermatitis in adults: clinical and epidemiological considerations

Cited by 23 publications

References 32 publications

Association of Perceived Stress with Atopic Dermatitis in Adults: A Population-Based Study in Korea

Association of Perceived Stress with Atopic Dermatitis in Adults: A Population-Based Study in Korea

Clinical Diversity of Atopic Dermatitis: A Review of 5,000 Patients at a Single Institute

Dupilumab treatment ameliorates clinical and hematological symptoms, including blood eosinophilia, in patients with atopic dermatitis

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