Atopic dermatitis in adults: A cross-sectional study in the department of dermatology, Antananarivo, Madagascar

Sendrasoa, Fandresena Arilala; Ramily, Samson Léophonte; Razafimaharo, Tsiory Iarintsoa; Ranaivo, Irina Mamisoa; Andrianarison, Malalaniaina; Raharolahy, Onivola; Ratovonjanahary, Volatantely; Razanakoto, Naina Harinjara; Rakotoarisaona, Mendrika Fifaliana; Andriamanantena, Noroiarisoa; Ramarozatovo, Lala Soavina; Fahafahantsoa, Rapelanoro Rabenja

doi:10.1016/j.jdin.2021.04.001

Cited by 5 publications

(5 citation statements)

References 19 publications

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“…The subjects in this study were dominated by females, as many as 75.56%. This is in accordance with previous epidemiological studies which said that atopic dermatitis was more common in female than male with a ratio of 1.27-2 : 1.1 (Munthaha et al, 2021;Sendrasoa et al, 2021).…”

Section: Discussionsupporting

confidence: 93%

“…This is consistent with the theory which stated that AD usually coexists with other atopic disorders such as allergic rhinitis, asthma, and food allergy (Solomon et al, 2019). This is also consistent with a prior study that found that 70% of AD patients had a first-degree relative who had atopy (Sendrasoa et al, 2021). The sensitization to HDM detected with local SPT was found in 26 subjects (57.77%).…”

Section: Discussionsupporting

confidence: 92%

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Correlation between Skin Prick Test and Specific IgE of Local Mites Allergen in Atopic Dermatitis Patients: an Indonesian Study

Anggraeni¹,

Umborowati²,

Damayanti³

et al. 2022

CMUJNS

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There are two methods that can be used to detect the causative of allergen that trigger the occurrence of Atopic Dermatitis (AD): skin prick test (SPT) and specific IgE (sIgE). Indonesia has developed SPT using local allergens extract to be used as an allergen diagnostic tool. This study aims to determine the correlation between local SPT from Indonesia and sIgE of mites. As many as 45 subjects who met the inclusion criteria were included in this study. Skin prick test was evaluated twice, one week apart. The first SPT was done with standard SPT, and second SPT with local SPT. The sIgE examination was examined at the second week, after performing SPT with local allergen extracts. The subjects in this study were 18-60 years old and dominated by females (75.56%). The three diagnostic tools used in this study showed the same clinical relevance (68.89%). From the mites sIgE examination, it was found that Tyrophagus putrescentiae was the most common sensitized allergen found in positive mites SPT (57.78%). The results of this showed significant results (P <0.05) and moderate correlation (r = 0.40-0.69) between sIgE class and wheal diameter of local SPT on mites allergen. This study found that local SPT from Indonesia has good clinical relevance and positive correlation with other diagnostic tools that already exist, therefore can be considered as a diagnostic tool for determining the cause of atopic dermatitis in the future. Keywords: Atopic dermatitis, Skin prick test, Specific IgE, Human and disease.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Correlation between Skin Prick Test and Specific IgE of Local Mites Allergen in Atopic Dermatitis Patients: an Indonesian Study

Anggraeni¹,

Umborowati²,

Damayanti³

et al. 2022

CMUJNS

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“…Low education level as a factor of poor treatment adherence in our study is consistent with the factors influencing therapeutic adherence according to the WHO [7]. Factors associated with high adherence include patient-related factors such as health literacy.…”

Section: Study Resultssupporting

confidence: 86%

Treatment Adherence Among Malagasy Patients with Atopic Dermatitis Seen at the Department of Dermatology, Antananarivo, Madagascar

Razanakoto,

Sendrasoa,

Rakotoarisaona

et al. 2024

IJCD

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Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by intense pruritic eczematous lesions. Poor adherence to treatment is a major factor limiting treatment outcomes in patients with AD. This study aimed to assess treatment adherence in Malagasy patients with AD. It was conducted over one year in children and adult patients with AD seen at the Department of Dermatology University Hospital Joseph Raseta Befelatanana, Antananarivo, Madagascar. Morisky Medication Adherence Scale-8 (MMAS-8) was used to assess patients’ treatment adherence. We included 44 children and 21 adults. The mean age was 4.29 ± 4.13 years and 35.28 ± 16.88 years, respectively. All of our patients receive topical treatment and no specific oral treatment such as biotherapy or immunosuppressant. A low adherence rate was observed in 61.90% of adult patients and the mean MMAS-8 score was 2.56 ± 1.6. In children, the mean MMAS¬8 score was 5.9 ± 1.53 and poor adherence was seen in 45.45%. The adherence level was significantly associated with age, educational status, and marital status (p < 0.05). Low treatment adherence is preponderant among Malagasy patients with AD. We did not find significant correlations between adherence levels and monthly income, frequency of follow-up, severity of AD, or insurance coverage.

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“…The prevalence of Ad continues to increase both in children and in adults in Madagascar. 39 Most AD patients are seen by general practitioners or by paediatricians before visiting dermatologists. So, most of cases seen by dermatologists are moderate to severe.…”

Section: Madagascarmentioning

confidence: 99%

Atopic dermatitis: A global health perspective

Faye,

Flohr,

Kabashima

et al. 2023

Acad Dermatol Venereol

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The International Society of AD (ISAD) organized a roundtable on global aspects of AD at the WCD 2023 in Singapore. According to the Global Burden of Disease (GBD) consortium, at least 171 million individuals were affected with AD in 2019, corresponding to 2.23% of the world population, with age‐standardized prevalence and incidence rates that were relatively stable from 1990 to 2019. Based on the panel experience, most AD cases are mild‐to‐moderate. Without parallel data on disease prevalence and severity, the GBD data are difficult to interpret in many regions. This gap is particularly important in countries with limited medical infrastructure, but indirect evidence suggests a significant burden of AD in low‐and‐medium resource settings, especially urban areas. The Singapore roundtable was an opportunity to compare experiences in World Bank category 1 (Madagascar and Mali), 3 (Brazil, China) and 4 (Australia, Germany, Qatar, USA, Singapore, Japan) countries. The panel concluded that current AD guidelines are not adapted for low resource settings and a more pragmatic approach, as developed by WHO for skin NTDs, would be advisable for minimal access to moisturizers and topical corticosteroids. The panel also recommended prioritizing prevention studies, regardless of the level of existing resources. For disease long‐term control in World Bank category 3 and most category 4 countries, the main problem is not access to drugs for most mild‐to‐moderate cases, but rather poor compliance due to insufficient time at visits. Collaboration with WHO, patient advocacy groups and industry may promote global change, improve capacity training and fight current inequalities. Finally, optimizing management of AD and its comorbidities needs more action at the primary care level, because reaching specialist care is merely aspirational in most settings. Primary care empowerment with store and forward telemedicine and algorithms based on augmented intelligence is a future goal.

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Atopic dermatitis in adults: A cross-sectional study in the department of dermatology, Antananarivo, Madagascar

Abstract: Background: Although atopic dermatitis (AD) is becoming a pressing public health concern in the world, Madagascar is underrepresented in the AD literature.

Cited by 5 publications

References 19 publications

Correlation between Skin Prick Test and Specific IgE of Local Mites Allergen in Atopic Dermatitis Patients: an Indonesian Study

Correlation between Skin Prick Test and Specific IgE of Local Mites Allergen in Atopic Dermatitis Patients: an Indonesian Study

Treatment Adherence Among Malagasy Patients with Atopic Dermatitis Seen at the Department of Dermatology, Antananarivo, Madagascar

Atopic dermatitis: A global health perspective

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