Atopic dermatitis and the atopic march

Spergel, Jonathan M.; Paller, Amy S.

doi:10.1016/j.jaci.2003.09.033

Cited by 1,029 publications

(886 citation statements)

References 62 publications

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“…The children with AD were at an increased risk of ITP, particularly those younger than 2 y, possibly because AD onset typically occurs in the first year of life, and is the first step in the allergic march (6-8); as children age, allergic diseases progress from AD to AR, and asthma has classically been observed in some patients (6)(7)(8). However, in this study, we observed no association between ITP and asthma, potentially because the mean age of the onset of asthma among children in Taiwan (7.24 y) follows the mean age of the onset of ITP (6.18 y) (9).…”

Section: Discussionmentioning

confidence: 99%

Association of primary immune thrombocytopenia and common allergic diseases among children

et al. 2015

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Background:Growing evidence has revealed a link between autoimmune and allergic diseases. However, few studies have assessed the relationship between allergic diseases and primary immune thrombocytopenia (ITP), an autoimmune disease frequently occurring in children. This population-based case-control study investigated the association between common allergic diseases and the subsequent risk of developing ITP during childhood. Methods: This study investigated 1,203 children younger than 18 y of age who were diagnosed with ITP between 1998 and 2008, as well as 4,812 frequency-matched controls. The odds ratios of the association between ITP and preexisting allergic diseases were calculated. results: Children with every type of allergic disease examined in this study (except asthma) exhibited an increased risk of developing ITP; the lowest adjusted odds ratio (aOR) was 1.39 for allergic conjunctivitis (95% confidence interval (CI) = 1.09-1.79), whereas the greatest aOR was 1.84 for allergic rhinitis (95% CI = 1.49-2.27). The aORs increased with the number of concurrent allergic diseases to 2.89 (95% CI = 1.98-4.22) for children with at least three allergic diseases. conclusion: Children with atopic diathesis have a greater risk of subsequently developing ITP. The fundamental determinants of this relationship warrant further study.

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Section: Discussionmentioning

confidence: 99%

Association of primary immune thrombocytopenia and common allergic diseases among children

et al. 2015

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“…34 The term atopic march has been coined to explain the sequential development of eczema, allergic rhinitis, and asthma. Recently, the existence of the atopic march has been both supported 19 and disputed. 23 The findings from our study support the concept of the atopic march continuing past childhood.…”

Section: Discussionmentioning

confidence: 99%

“…[15][16][17] A recent systematic review indicated that about 1/3 of children with atopic eczema before age 4 years will develop asthma by age 6 years or older. 18 The eczema/asthma association has been explained by invoking the atopic march [19][20][21] whereby children with eczema have a high risk of progression to asthma and/or allergic rhinitis later in childhood. Epicutaneous sensitization of the bronchusassociated lymphoid tissue has been proposed as a causal pathway.…”

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confidence: 99%

Childhood eczema and asthma incidence and persistence: A cohort study from childhood to middle age

Burgess¹,

Dharmage²,

Byrnes³

et al. 2008

Journal of Allergy and Clinical Immunology

102

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“…1 Approximately 15% to 20% of infants in Western countries suffer from this disease, and the prevalence is increasing. [1][2][3][4][5] Intractable itching and related sleep loss account for much of the suffering experienced by affected infants. 6,7 AD also affects the appetite and mood of infants.…”

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confidence: 99%

Safety and Tolerability of 1% Pimecrolimus Cream Among Infants: Experience With 1133 Patients Treated for Up to 2 Years

et al. 2006

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Pimecrolimus is a calcineurin inhibitor developed for the topical treatment of atopic dermatitis. During the clinical development of 1% pimecrolimus cream, 1133 patients 3 to 23 months of age with mild to severe atopic dermatitis were treated for up to 2 years. The objective of this review is to discuss the safety and tolerability of 1% pimecrolimus cream among infants, on the basis of the combined results from all studies (4 pharmacokinetic studies and 6 clinical trials) conducted among these patients. Pimecrolimus blood concentrations measured for 35 patients were consistently low (Յ1 ng/mL in Ͼ80% of samples), irrespective of the disease severity and extent, and remained low during intermittent treatment for up to 1 year. The level of systemic exposure to pimecrolimus among infants was comparable to that observed for older pediatric patients enrolled in the same studies and treated in the same way with 1% pimecrolimus cream, which indicated that young pediatric patients are not at higher risk of significant percutaneous absorption of topically applied pimecrolimus, despite their large skin surface area/body mass ratio. The 6 clinical trials included a total of 1098 infants, who were treated for periods ranging from 4 weeks to 2 years. Most of these patients (60%) had moderate to severe disease at baseline. The most frequently reported adverse events were common childhood disorders such as nasopharyngitis, pyrexia, upper respiratory tract infections, ear infections, and bronchitis. During the double-blind (DB) studies or DB phases of studies, the incidence rates for the most frequently reported adverse events were similar for patients who received 1% pimecrolimus cream and patients who received the vehicle, except for the incidence of teething, which was higher among the pimecrolimus-treated infants (relative risk: 2.02; 95% confidence interval: 1.32-3.27). Treatment with 1% pimecrolimus cream was not associated with an increase in the overall incidence of nonskin infections, compared with the vehicle (relative risk: 1.015; 95% confidence interval: 0.88 -1.18). The incidence density (ID) rates for total bacterial, fungal, parasitic, and viral skin infections during the DB studies or DB phases of www.pediatrics.org/cgi

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Atopic dermatitis and the atopic march

Cited by 1,029 publications

References 62 publications

Association of primary immune thrombocytopenia and common allergic diseases among children

Association of primary immune thrombocytopenia and common allergic diseases among children

Childhood eczema and asthma incidence and persistence: A cohort study from childhood to middle age

Safety and Tolerability of 1% Pimecrolimus Cream Among Infants: Experience With 1133 Patients Treated for Up to 2 Years

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