Atopic dermatitis and hidradenitis suppurativa: An under-recognized pair

Rick, Jonathan W.; Alavi, Afsáneh; Hsiao, Jennifer L.; Yosipovitch, Gil; Shi, Vivian Y.

doi:10.1016/j.jaad.2021.03.126

Cited by 3 publications

(5 citation statements)

References 5 publications

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“…The prevalence of HS in this study is relatively low compared to that reported in a systematic review (0.4%) 17 . In studies conducted in the USA, there was a difference in the prevalence and incidence of HS according to race 9,18 .…”

Section: Discussioncontrasting

confidence: 82%

“…The prevalence of HS in this study is relatively low compared to that reported in a systematic review (0.4%). 17 In studies conducted in the USA, there was a difference in the prevalence and incidence of HS according to race. 9,18 The prevalence of HS in the group including Asians was 0.04%, which was higher compared to 0.1% for White and 0.3% for African Americans.…”

Section: Discussionmentioning

confidence: 99%

“…In most studies, it was commonly reported that HS is associated with metabolic syndrome, cardiovascular disease, inflammatory bowel syndrome, autoimmune diseases, and mental health issues. 2,[4][5][6]11 In addition, some recent studies have reported an association between HS and atopic dermatitis, 16,17 while others have reported that liver and kidney diseases are associated with HS. 2 For comparison for comorbidities, patients with HS were matched 1:20 for age, sex, insurance type, and income level with the control group without HS.…”

Section: Hs Comorbiditiesmentioning

confidence: 99%

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Epidemiology and comorbidity of hidradenitis suppurativa in Korea for 17 years: A nationwide population‐based cohort study

Lee

Heo

Lee

et al. 2023

The Journal of Dermatology

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Hidradenitis suppurativa (HS) is associated with various metabolic and autoimmune diseases. The epidemiology has been analyzed in various studies worldwide. However, epidemiological data on HS for Asian populations are limited. This study aimed to analyze the change in the prevalence and incidence of HS over 17 years in South Korea using the Korean National Health Insurance Service (NHIS) database. This study also evaluated the comorbidities in patients with HS. Population‐based data from the NHIS database of Korea were obtained between January 2003 and December 2019. Odds ratios were estimated to determine the association between comorbidities and HS during the study period. Hazard ratios for the risk of incident comorbidities in patients with HS were obtained using the multivariable Cox proportional hazard analysis. This study included 45 511 patients with HS and 910 220 controls matched for age, sex, insurance type, and income level. The incidence rate of HS per 1 000 000 person‐years in Korea increased from 11.69 in 2003 to 78.78 in 2019. The annual prevalence per 1 000 000 people also increased from 34.68 in 2003 to 140.10 in 2019, showing a similar trend. Many comorbidities, including atopic, metabolic and end‐organ, autoimmune/inflammatory, and psychiatric diseases were associated with HS at baseline. In many diseases, the risk of incident comorbidities in patients with HS was higher than that in controls. The incidence and prevalence of HS in Korea have increased over the past 17 years. Various comorbidities, including allergic diseases, hypertension, diabetes mellitus, dyslipidemia, myocardial infarction, chronic hepatitis and cirrhosis, chronic kidney disease, inflammatory bowel diseases, rheumatoid arthritis, vitamin D deficiency, and psychiatric diseases, were associated with HS. Physicians need to keep in mind and closely monitor these comorbidities in patients with HS.

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Section: Discussioncontrasting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Hs Comorbiditiesmentioning

confidence: 99%

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Epidemiology and comorbidity of hidradenitis suppurativa in Korea for 17 years: A nationwide population‐based cohort study

Lee

Heo

Lee

et al. 2023

The Journal of Dermatology

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“…Based on the functions of involved cytokines in HS pathogenesis, Schell et al [5] stated that HS patients could probably associated with less risk of allergic diseases. Nevertheless, recent evidences indicated that Th17/IL-17 inflammatory pathway could also play a role in the HS-allergic disease interaction [9,10]. As for the mechanism of asthma, the term "non-T2 asthma" had been identified and it was observed that Th17 family was involved in the immunologic pathway [24][25][26].…”

Section: Discussionmentioning

confidence: 99%

“…However, a recent study indicated that HS could have potential bidirectional association with atopic dermatitis [9]. It was hypothesized that pathway oth-er than Th1/Th2 could influence the interaction between HS-atopic dermatitis [9,10]. Aside from atopic dermatitis, studies reported inconsistent results while evaluating the risk of allergic rhinitis and conjunctivitis in HS patients [5,9].…”

Section: Introductionmentioning

confidence: 99%

Risk of Atopic Diseases in Patients with Hidradenitis Suppurativa: A Systematic Review and Meta-Analysis of Observational Studies

2023

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Background Hidradenitis suppurativa (HS) and allergic diseases were considered to have different immune pathways involved. However, available evidences seemed to be inconsistent and the association was not well-developed yet. Objective To perform a systematic review and meta-analysis to evaluate the association between HS and atopic diseases, including asthma, atopic dermatitis, allergic rhinitis and conjunctivitis. Methods Search in databases including PubMed, Embase and Web of Science were performed. Synonyms were determined based on MeSH terms and Emtree. Observational studies with proper comparative arm were selected. For quality evaluation of extracted studies, the Newcastle-Ottawa Scale was utilized. Odds ratio of atopic dermatitis, asthma, allergic rhinitis and conjunctivitis were evaluated in HS patients (comparing with non-HS people). I2 value was applied to evaluate the heterogeneity within studies. Results After appraising 1,654 studies, in total, 12 studies were selected for data extraction. In adjusted models, people with HS is significantly associated with higher risk of having asthma, with a pooled odds ratio of 1.50 (95% CI, 1.24-1.81). Risk of presenting atopic dermatitis in HS patients was also increased, with an odd ratio of 4.10 (95% CI, 2.16-8.18). The association remained its significance in sensitivity models. Evidences were insufficient to support the association between HS and allergic rhinitis and conjunctivitis. Conclusion Current evidence supported that atopic dermatitis and asthma were associated with HS. Physicians should be aware of the reported association while caring people with HS and related screening of allergies comorbidities should be recommended.

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Reply to: Comments on “Hidradenitis suppurativa and atopic dermatitis: A two-way association”

Sherman

Bitan

Leshem

et al. 2021

Journal of the American Academy of Dermatology

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Atopic dermatitis and hidradenitis suppurativa: An under-recognized pair

Cited by 3 publications

References 5 publications

Epidemiology and comorbidity of hidradenitis suppurativa in Korea for 17 years: A nationwide population‐based cohort study

Epidemiology and comorbidity of hidradenitis suppurativa in Korea for 17 years: A nationwide population‐based cohort study

Risk of Atopic Diseases in Patients with Hidradenitis Suppurativa: A Systematic Review and Meta-Analysis of Observational Studies

Reply to: Comments on “Hidradenitis suppurativa and atopic dermatitis: A two-way association”

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