Atopic dermatitis and dementia risk

Pan, Tai‐Long; Bai, Ya Mei; Cheng, Chih Ming; Tsai, Shih Jen; Tsai, Chia Fen; Su, Tung Ping; Li, Cheng Ta; Lin, Wei Chen; Chen, Tzeng Ji; Liang, Chih Sung; Chen, Mu Hong

doi:10.1016/j.anai.2021.03.001

Cited by 26 publications

(21 citation statements)

References 34 publications

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“…Two further prospective studies from Taiwan and the United Kingdom reported an association between AD and a higher risk of dementia 12,13 . A Taiwanese study reported a statistically significant association for mild AD but not for moderate‐to‐severe where statistical significance did not remain in the adjusted model, particularly after adjusting for all‐cause clinical visits 13 . A UK‐based study reported a 27% higher risk of dementia with a similar magnitude across the subtypes of dementia and a higher risk with increasing severity of the exposure.…”

Section: Discussionmentioning

confidence: 99%

“…To the best of our knowledge, only three studies have investigated an association between AD and dementia using prospectively recorded data, with inconsistent findings 12–14 . In addition, most studies reporting an association between inflammatory markers and dementia risk have identified inflammation at older ages 11 …”

Section: Introductionmentioning

confidence: 99%

“…To the best of our knowledge, only three studies have investigated an association between AD and dementia using prospectively recorded data, with inconsistent findings. [12][13][14] In addition, most studies reporting an association between inflammatory markers and dementia risk have identified inflammation at older ages. 11 Using large-scale Swedish register data, we used three cohorts to examine the association of AD and a nonspecific marker of systemic inflammation-erythrocyte sedimentation rate (ESR) with subsequent dementia risk.…”

Section: Introductionmentioning

confidence: 99%

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Atopic dermatitis, systemic inflammation and subsequent dementia risk

Vingeliene,

Hiyoshi,

Carlberg

et al. 2023

JEADV Clinical Practice

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BackgroundAtopic dermatitis is a chronic inflammatory skin disease and inflammation has been implicated in development of other chronic diseases, but few studies have examined the relationship with dementia.ObjectivesThis study examines associations of atopic dermatitis (AD) and systemic inflammation in adolescence measured using erythrocyte sedimentation rate (ESR), as well as AD diagnosed in adulthood, with dementia risk.MethodsWe used three Swedish register‐based cohorts. Cohort I (N = 795,680) comprised men, born in 1951–1968, who participated in the military conscription examinations with physician‐assessed AD and ESR; Cohort II (N = 1,757,600) included men and women, born in 1951–1968; and Cohort III (N = 3,988,783) included all individuals in Sweden, born in 1930–1968. We used Cox regression, estimating hazard ratios (HR), with the follow‐up from 50 years of age to dementia diagnosis, date of emigration, death, or 31 December 2018, whichever occurred first. Further, we used a sibling comparison design to adjust for unmeasured confounders shared among siblings.ResultsCohort I: 1466 dementia events were accrued during follow‐up of 7.8 years, with a crude rate of 21.6 [95% confidence interval (CI): 20.6, 22.8] per 100,000 person‐years. Cohort II: 3549 dementia events were accrued during follow‐up of 7.4 years, with a crude rate of 23.7 (95% CI: 22.9, 24.5) per 100,000 person‐years. Cohort III: 120,303 dementia events were accrued during follow‐up of 23.7 years, with a crude rate of 180.3 (95% CI: 179.3, 181.3) per 100,000 person‐years. In multivariable analysis using Cohort I, there was no association between AD and dementia [HR 0.68 (95% CI 0.32, 1.43)], nor with moderate [HR 0.71 (95% CI: 0.46, 1.10)] or high [HR 1.23 (95% CI: 0.87, 1.75)] ESR. AD was not associated with dementia risk in Cohort II [HR 1.28 (0.97, 1.71)] or Cohort III [HR 1.01 (0.92, 1.11)].ConclusionsAD was not associated with dementia risk, neither was systemic inflammation measured by ESR in adolescence.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Atopic dermatitis, systemic inflammation and subsequent dementia risk

Vingeliene,

Hiyoshi,

Carlberg

et al. 2023

JEADV Clinical Practice

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“…This is a nationwide population-based cohort study using the National Health Insurance System (NHIS), a government-operated mandatory social health insurance programme that contains health information on approximately 50 million South Koreans ( 12 , 13 ).…”

Section: Methodsmentioning

confidence: 99%

“…Few studies have focused on the relationship between dementia risk and AD. The risk of dementia and Alzheimer’s disease is reportedly increased in patients with AD ( 12 ). However, that study included only a small number of patients with AD and did not examine risk factors for dementia.…”

Section: Introductionmentioning

confidence: 99%

Increased Risk of Dementia in Patients with Atopic Dermatitis: A Nationwide Population-Based Cohort Study

Woo¹,

Cho²,

Han³

et al. 2023

Acta Derm Venereol

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Atopic dermatitis (AD) is a chronic inflammatory skin disorder with bimodal incidence peaks in early childhood and middle-aged and older adults. Few studies have focused on the risk of dementia in AD. The aims of this study were to analyse the incidence, and risk factors for dementia in patients with AD. This nationwide population-based retrospective cohort study enrolled 38,391 adults ≥ 40 years of age with AD and 2,643,602 controls without AD from the Korean National Health Insurance System (NHIS) database from 2009 to 2016. The cumulative incidence probability of all-cause dementia, Alzheimer’s disease, or vascular dementia at 8 years was 50, 39, and 7 per 1,000 person-years in patients with AD, respectively. The adjusted risks of all-cause dementia (hazard ratio (HR), 1.072; 95% confidence interval (95% CI) 1.026–1.120), and Alzheimer’s disease (HR 1.051; 95% CI 1.000–1.104) were increased in patients with AD. The effect of AD on the development of all-cause dementia and Alzheimer’s dementia varied according to age and diabetes mellitus (all p for interaction, < 0.05). The risks of all-cause dementia and Alzheimer’s disease were increased in patients with AD. Management of modifiable risk factors is important for preventing dementia in patients with AD.

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Allergic Diseases and Risk of Incident Dementia and Alzheimer's Disease

Joh

Kwon

Son

et al. 2022

Annals of Neurology

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Objective: To examine the associations between the allergic triad (asthma, allergic rhinitis, atopic dermatitis) and risk of dementia. Methods: Participants comprised 6,785,948 adults aged ≥40 years who participated in a national health examination in 2009 without any history of dementia before baseline. From 2009 to 2017, we prospectively investigated the associations between physician-diagnosed allergic diseases and risk of incident dementia (all-cause, Alzheimer's disease [AD], vascular dementia [VaD]) ascertained using national health insurance claims data. Results: During 8.1 years of follow-up, 260,705 dementia cases (195,739 AD,32,789 VaD) were identified. Allergic diseases were positively associated with dementia risk. Compared with individuals without allergic diseases, multivariable hazard ratios (HRs) of all-cause dementia were 1.20 (95% confidence interval [CI] 1.19-1.22) in those with asthma, 1.10 (95% CI 1.09-1.12) with allergic rhinitis, 1.16 (95% CI 1.11-1.21) with atopic dermatitis, and 1.13 (95% CI 1.12-1.14) with any of these allergies. Similarly, individuals with any of the allergic triad had a higher risk of AD (HR 1.16, 95% CI 1.14-1.17) and VaD (HR 1.04; 95% CI 1.01-1.06) than those without any allergic disease. As the number of comorbid allergic diseases increased, the risk of dementia increased linearly (P trend ≤ 0.002). Compared with individuals without allergies, those with all three allergic diseases had substantially increased risk of all-cause dementia (

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Atopic dermatitis and dementia risk

Cited by 26 publications

References 34 publications

Atopic dermatitis, systemic inflammation and subsequent dementia risk

Atopic dermatitis, systemic inflammation and subsequent dementia risk

Increased Risk of Dementia in Patients with Atopic Dermatitis: A Nationwide Population-Based Cohort Study

Allergic Diseases and Risk of Incident Dementia and Alzheimer's Disease

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