Atopic conditions other than asthma and risk of the 2009 novel H1N1 infection in children: A case‐control study

Salas, Carlos; Mehra, Sonia; Crespo, Maria R. Pardo; Juhn, Young J.

doi:10.2500/aap.2013.34.3686

Cited by 10 publications

(9 citation statements)

References 18 publications

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“…Also, oral corticosteroid therapy among patients using vitamin D was not associated with increased risk of pneumonia but decreased the risk of pneumonia. 99 The study findings described above on the association of asthma with the increased risks of serious pneumococcal disease, 28 B pertussis , 50 S pyogenes upper respiratory infections, 40 recurrent/persistent otitis media, 30 H1N1 influenza, 56 community-acquired E coli BSI, 52 and herpes zoster 91 among patients with asthma were independent of the use of inhaled or systemic corticosteroids. Talbot et al 31 reported similar findings.…”

Section: Potential Factors Affecting the Association Between Atopic Cmentioning

confidence: 88%

“…55 Other studies reported both an increased risk of H1N1 infection among children with other atopic conditions (adjusted OR, 1.89; 95% CI, 1.15-3.12) 56 and more severe H1N1 infection (risk of hospitalization) among those with than without asthma (matched OR, 2.31; 95% CI, 1.13-4.73). 57 Two independent studies identified asthma as the single most common comorbid condition among patients with severe H1N1 infection (hospitalization or death), with rates of asthma ranging from 10% to 32%.…”

Section: Effect Of Atopic Conditions On the Risk Of Microbial Infectionsmentioning

confidence: 99%

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Risks for infection in patients with asthma (or other atopic conditions): Is asthma more than a chronic airway disease?

Juhn¹

2014

Journal of Allergy and Clinical Immunology

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123

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Most of the research effort regarding asthma has been devoted to its causes, therapy, and prognosis. There is also evidence that the presence of asthma can influence patients’ susceptibility to infections, yet research in this aspect of asthma has been limited. There is additional debate in this field, with current literature tending to view the increased risk of infection among atopic patients as due to opportunistic infections secondary to airway inflammation, especially in severe atopic diseases. Other evidence, however, suggests that such risk and its underlying immune dysfunction may be a phenotypic or clinical feature of atopic conditions. This review argues that 1) improved understanding of the effects of asthma or other atopic conditions on the risk of microbial infections will bring important and new perspectives to clinical practice, research, and public health concerning atopic conditions and that 2) research efforts into the causes and effects of asthma must be juxtaposed because they are likely to guide each other.

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Section: Potential Factors Affecting the Association Between Atopic Cmentioning

confidence: 88%

Section: Effect Of Atopic Conditions On the Risk Of Microbial Infectionsmentioning

confidence: 99%

Risks for infection in patients with asthma (or other atopic conditions): Is asthma more than a chronic airway disease?

Juhn¹

2014

Journal of Allergy and Clinical Immunology

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123

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“…To the best of our knowledge, this is the first rhinitis model in which this unique and powerful response to influenza virus has been described. There are several reports that examine susceptibility to influenza A among individuals with allergic rhinitis; a model such as this might be useful for further exploration of these clinical observations.…”

Section: Discussionmentioning

confidence: 99%

Alternaria alternata challenge at the nasal mucosa results in eosinophilic inflammation and increased susceptibility to influenza virus infection

Redes

Percopo

et al. 2018

Clin Experimental Allergy

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Repetitive administration of A. alternata resulted in inflammation of the nasal mucosae and unanticipated morbidity and mortality in response to subsequent challenge with influenza virus. Interestingly, and in contrast to findings in the lower airways, eosinophils recruited to the nasal passages provided no protection against lethal infection. As increased susceptibility to influenza virus among individuals with rhinitis has been the subject of several clinical reports, this model may be used for further exploration of these observations.

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“…2 Infection with influenza in children with allergies during the 2009 epidemic was diagnosed much more frequently than in children without diagnosed allergies. 3 The risk of developing severe bronchial asthma is particularly high when the child is exposed to airborne allergens and a viral infection. 4 Patients with atopic BA are also highly susceptible to viral infections, especially by the rhinovirus.…”

Section: The Susceptibility Of Patients With Allergies To Infectionmentioning

confidence: 99%

Infectious and Non-Infectious Sensitisation of Patients with Bronchial Asthma and Chronic Obstructive Pulmonary Disease

Gb¹

2016

JLPRR

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The study involved 169 people, of which 33 were practically healthy, 69 had bronchial asthma, 24 had bronchial asthma combined with chronic obstructive pulmonary disease, 35 had COPD and 8 had community-acquired pneumonia. We assessed the presence of IgE to tick allergens, dust allergens, and the combined allergens of grass, trees, weeds and flower pollen. We determined the presence of IgE and IgG to the allergens Strept. рneumon., Haemofil. influenzae, Neisseria рerflava and Staph. аureus. We assessed the presence, multiplicity, severity and combination of sensitisation to the presence of specialised IgE towards infectious and atopic allergens. All study groups displayed sensitisation, including heaslthy people and patients with COPD and community-acquired pneumonia, who did not show clinical allergy symptoms. A statistically significant direct correlation was established between IgG and IgE to Strept. Pneumoniae and Haemofilus influenza in healthy subjects and those with pulmonary conditions. The IgE or IgG reaction to Neisseria perflava and Staph. аureus did not show a significant correlation in either healthy or affected subjects.Keywords: sensitization, allergy, mild bronchial asthma, immunoglobulin, allergen, food, industry, drug-related and other allergens, and every year new names are added to this list. The 15 most clinically common allergens are considered to be the main ones with diagnostic complexes being created for sensitisation diagnosis, which use specialised IgE. Using skin samples with airborne allergens, the rates of sensitisation in patients with BA varies between 51% and 81.9%. 16 The main fundamental mechanism of sensitisation is the formation of specialised IgE.17 There is a correlation between levels of specialised IgE, total IgE, the results of skin allergy testing, and BA severity.18 Patients with mild and moderate BA have a significant correlation between levels of specialised IgE to non-infectious allergens and the results of skin tests, the acetylcholine inhalation test, and the exhaled nitric oxide content. 19It is important to note that sensitisation and the related appearance of antigen-specific IgE antibodies is not necessarily accompanied by clinical allergy symptoms. 20 Therefore, sensitisation that manifests as an increased content of specialised class IgE antibodies can occur in people without allergy symptoms, including practically healthy people, as well as in people with allergies. An allergy is the combination of sensitisation (increased number of antigen-specific IgE antibodies) and clinical signs of an allergic condition. 21The sensitivity to airborne allergens does not decrease with time. 19 The biochemical properties of allergens and the sensitivity of respiratory epithelium to their active components can increase the permeability of the respiratory mucous membrane to respiratory allergens. Many allergens contain serine, cysteine and other proteases, which disrupt the barrier function of the respiratory epithelium and increase the allergenic effect of respirat...

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Atopic conditions other than asthma and risk of the 2009 novel H1N1 infection in children: A case‐control study

Abstract: A recent study showed an increased risk of 2009 novel H1N1 influenza (H1N1)

Cited by 10 publications

References 18 publications

Risks for infection in patients with asthma (or other atopic conditions): Is asthma more than a chronic airway disease?

Risks for infection in patients with asthma (or other atopic conditions): Is asthma more than a chronic airway disease?

Alternaria alternata challenge at the nasal mucosa results in eosinophilic inflammation and increased susceptibility to influenza virus infection

Infectious and Non-Infectious Sensitisation of Patients with Bronchial Asthma and Chronic Obstructive Pulmonary Disease

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