Atopic and non‐atopic eosinophilic oesophagitis are distinguished by immunoglobulin E‐bearing intraepithelial mast cells

Mulder, Daniel J.; Mak, Nanette; Hurlbut, David; Justinich, Christopher J.

doi:10.1111/j.1365-2559.2012.4303.x

Cited by 36 publications

(31 citation statements)

References 27 publications

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“…EoE is induced by food or aeroallergen exposure, characterized by intraepithelial eosinophil accumulation, eosinophil granule deposition in the extracellular tissue, and epithelial cell hyperplasia and is resistant to acid suppression therapy (10,11,14,20,27,31). Eosinophils and mast cells are increased in the esophageal mucosa of experimental and human EoE (2,9,17,19,25,30), but their role in disease pathogenesis is unclear. Mast cells express the high-affinity receptor for IgE on their surface (3,4,15,16) that initiates a complex process of signal transduction that releases proinflammatory mediators, cytokines, and chemokines (3,4,12,16).…”

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confidence: 99%

Pathogenic role of mast cells in experimental eosinophilic esophagitis

Niranjan

Mavi

Rayapudi

et al. 2013

American Journal of Physiology-Gastrointestinal and Liver Physi

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Eosinophilic esophagitis (EoE) is a chronic allergic disease characterized by esophageal intraepithelial eosinophils, extracellular eosinophil granule deposition, induced mast cell accumulation, and epithelial cell hyperplasia. However, the processes involved in the development of a number of these characteristics are largely unknown. Herein, we tested the hypothesis whether induced mast cell accumulation in the esophagus has a role in promoting EoE pathogenesis. Accordingly, we induced experimental EoE in wild-type mice, mast cell-deficient WWv mice, and mast cell-reconstituted WWv mice. We report that esophageal mast cell numbers increase in parallel with eosinophils in a dose- and time-dependent manner following the induction of allergen-induced EoE. The induced mast cells are localized in the esophageal lamina propria and muscular mucosa but have no influence on promoting esophageal eosinophilia. The 5'-bromodeoxyuridine (BrdU) incorporation analysis indicated that mast cells have a significant role in muscle cell hyperplasia and hypertrophy. In addition, the wild-type and mast cell-reconstituted WWv mice showed a comparable number of BrdU⁺ cells in the esophageal muscular mucosa following allergen-induced EoE. In conclusion, we provide for the first time direct evidence that mast cell promotes muscle cell hyperplasia and hypertrophy and may have a significant role in promoting esophageal functional abnormalities in EoE.

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confidence: 99%

Pathogenic role of mast cells in experimental eosinophilic esophagitis

Niranjan

Mavi

Rayapudi

et al. 2013

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…IgE-bearing mast cells were increased in atopic EoE patients but not in non-atopic EoE patients [38], but no differences were noted regarding mast cell counts or activation between atopic and non-atopic patients [39].…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 96%

Disease associations in eosinophilic oesophagitis and oesophageal eosinophilia

Lucendo

2015

Best Practice & Research Clinical Gastroenterology

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“…Numbers of MC TC also correlated with PGD 2 levels in the bronchoalveolar lavage, indicating that MC TC may produce more PGD 2 in severe asthma. Increased numbers of intraepithelial mast cells are also found in H. pylori gastritis (Caruso et al, 2011), eosinophilic esophagitis (Mulder et al, 2012), and parasitic infections (Friend et al, 1996). However, what regulates the numbers and functions of intraepithelial mast cells in mucosal diseases is not clear.…”

Section: Asthmamentioning

confidence: 97%