Atopic Allergy and Immunoglobulins in Children With Adenoids and Recurrent Otitis Media

Kjellman, N.‐I. M.; Synnerstad, B.; Hansson, Lars O.

doi:10.1111/j.1651-2227.1976.tb04938.x

Cited by 40 publications

(16 citation statements)

References 26 publications

(4 reference statements)

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“…The variables were treated as categorical. Some variables were categorical by nature (variables 6,7,8,16, and 17) and others were divided into two categories either in a way that was relevant for the study (i.e., daycare at home or outside the home) or by choosing a cutoff point using the distribution of the whole series of 183 infants (Table 1).…”

Section: Methodsmentioning

confidence: 99%

“…In a Finnish follow-up study 5% of infants had OM during the first 6 months of life, 36% during their 1st yr, and 59% during their 2nd and 3rd yr (3). Several risk factors have been identified: daycare outside the home (4), enlarged adenoids (5), feeding in the horizontal position (6), smoking at home (7), and atopy (8,9), particularly food allergy (9). Some studies suggest a protective effect of breast-feeding (3, 10, I I) but others detect none (2,13).…”

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Risk Factors for Infantile Recurrent Otitis Media: Atopy but Not Type of Feeding

et al. 1988

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ABSTRACT. We followed 183 infants from birth to 2.3 yr of age. Of these infants 28 had recurrent otitis media (ROM), defined as five or more separate episodes of otitis media (OM) during the first 2 yr of life or four such episodes during their 2nd yr. The O M presented during their 1st yr (early-onset ROM) in 12 infants and during their 2nd yr (2nd yr ROM) in 16. Eighty infants had no O M and served as a comparison group. Regarding type of feeding, the infants with early-onset ROM did not differ from their age-matched pairs in the comparison group either 1 month before the first O M or at the time of first episode of OM. Exclusive breast-feeding did not prevent O M and early weaning was not a risk factor for ROM. Atopy was associated with ROM with a relative risk of 1.9 (95% confidence limits 1.2-3.2). It was particularly prevalent among the infants with early-onset ROM, in 67 versus in 25% in the comparison group ( p < 0.01). During , the 2nd yr daily contact with five or more children was associated with ROM with a relative risk of 2.1 (1.3-3.3). The infants with 2nd-yr ROM were in daily contact with more children than the comparison group (mean 11 versus 5; p < 0.001). Parental smoking was more frequent among the infants with ROM than in the comparison group (54 versus 33%; p < 0.05). In the infants with early-onset ROM plasma concentration of IgM antibodies to cow's milk was highest at the age of 9 months, and the concentration of IgE was highest at the ages of 9 and 12 months. In conclusion atopy, not the type of feeding, is a risk factor for early-onset ROM, and daycare outside the home for ROM during the 2nd yr. (Pediatr Res 23: 509-512,1988) Abbreviations OM, otitis media ROM, recurrent otitis media CM, cow's milk CMA, cow's milk allergy OM may occur in early infancy, but its incidence increases rapidly after the age of 6 months (1, 2). In a Finnish follow-up study 5% of infants had OM during the first 6 months of life, 36% during their 1st yr, and 59% during their 2nd and 3rd yr (3). Several risk factors have been identified: daycare outside the home (4), enlarged adenoids (5), feeding in the horizontal position (6), smoking at home (7), and atopy (8,9), particularly food allergy (9). Some studies suggest a protective effect of breast- feeding (3, 10, I I) but others detect none (2, 13). Any study of the impact of feeding on morbidity is beset with numerous methodologic limitations (14).In this prospective study we followed 198 infants throughout the 1st yr of life, carefully recording their feeding regimen, illnesses, and environment. For 183 of the infants similar data were obtained from the parents regarding the 2nd yr by a detailed questionnaire. From these data we analyzed the risk factors for ROM. MATERIALS AND METHODSWe followed 198 healthy newborns from birth; they were seen at clinic visits at 2, 4, 6, 9, and 12 months of age, and whenever they had any problems regarding feeding, nursing, or illness. At a mean age of 2.3 yr 60 of the infants were examined by one of us (V-M.T.), and a questi...

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Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

Risk Factors for Infantile Recurrent Otitis Media: Atopy but Not Type of Feeding

et al. 1988

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“…Kjellman ct al. [9] reported an overprescntation of atopie allergy in the group of children suffering from repeated otitis media. Minor ci al.…”

Section: Discussionmentioning

confidence: 99%

“…In children under 2 years ofagc the antibody response against bacterial polysaccharides is not fully mature [7.S]. The rote of ehitdhood altergy as a risk faetor for repeated infections with capsutated tnicro-organisms has been controvcrsiat [9,10]. The present sttidy was utidertaken to examine whether the IgA, IgG and IgM atitibody responses against a polysaccharide antigen differ in atopic and non-atopic children.…”

Section: Introductionmentioning

confidence: 99%

A comparison of the development of antibody responses to the polysaccharide antigen (Candida albicans mannan) in atopic and healthy infants and children

Nermes

Fälth‐Magnusson

Savolainen

et al. 1996

Clin Experimental Allergy

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“…AR typically arises after the second year of life, and at least two or more seasons of pollen exposure are necessary for sensitization in the pediatric AR group (6). The comorbid relationship between the adenoid and adenotonsillar hypertrophy of the upper airway allergy, which is termed as inflammation of the mucosal barrier of the upper airways due to IgE-mediated hypersensitivity, has been shown in many studies (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Adenoid Vegetation in Children with Allergic Rhinitis

Bozkurt¹,

Dizdar²,

Korkut³

et al. 2016

Turk Arch Otorhinolaryngol

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Objective: Pediatric patients with nasal obstruction due to adenoid vegetation (AV) can also encounter allergic rhinitis (AR) as a comorbidity. The aim of the study was to estimate the incidence of mite sensitization and its effect on adenoid size in children who underwent adenoidectomy.Methods: This prospective randomized study conducted between August and September 2014 included 84 children. Skin Prick Test (SPT) for inhalant allergens was preoperatively applied to all children who underwent adenoidectomy for nasal obstruction. Children were divided into two study groups: AV only (Group I) (n=52) and AV with Dermatophagoides Pteronyssinus and/or D. farinae allergy (Group II) (n=32). Postoperative specimen volumes, visual analogue scale (VAS) scores, and adenoid volumes measured using flexible fiberoptic nasopharyngolaryngoscopy were compared between the two groups.Results: Postoperative specimen volume measures were higher in Group II compared with those in Group I (p<0.05). Furthermore, in preoperative endoscopic examination, adenoid volume measures were higher in Group II compared with those in Group I (p<0.05). Pre and postoperative VAS scores in SPT+ group were higher in the Group II (p<0.05) than those in Group I. Conclusion:We observed that children with AR tend to have an early onset of symptoms of adenoid hypertrophy. We believe that focusing on the management of role of allergy regarding these early symptoms will reduce the need for surgery in a large number of cases. We suggest that SPT must be performed in all children with AV and adenoid examination should not be neglected in children with AR. Keywords: Adenoid vegetation, allergic rhinitis, adenoid volume

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Atopic Allergy and Immunoglobulins in Children With Adenoids and Recurrent Otitis Media

Cited by 40 publications

References 26 publications

Risk Factors for Infantile Recurrent Otitis Media: Atopy but Not Type of Feeding

Risk Factors for Infantile Recurrent Otitis Media: Atopy but Not Type of Feeding

A comparison of the development of antibody responses to the polysaccharide antigen (Candida albicans mannan) in atopic and healthy infants and children

Adenoid Vegetation in Children with Allergic Rhinitis

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