ATOPE+: An mHealth System to Support Personalized Therapeutic Exercise Interventions in Patients With Cancer

Moreno-Gutiérrez, Salvador; Postigo-Martín, Paula; Damas, Miguel; Pomares, H.; Baños, Oresti; Arroyo-Morales, Manuel; Cantarero‐Villanueva, Irene

doi:10.1109/access.2021.3049398

Cited by 9 publications

(14 citation statements)

References 76 publications

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“…These results highlight that ATOPE+ could be an easy and efficient system to measure tailored readiness in BCS and a tool to improve health by helping professionals to prescribe optimal and safe exercise doses. Moreover, ATOPE+ may provide reliable data-driven analysis with machine learning algorithms, as originally described in its architecture 16 .…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, this has been commonly used in athletes, but its use is not as common in the clinical population (ClinicalTrials.gov Identifier: NCT03745742), and specifically in the oncological population, where prescription is mostly informed by survivors' symptoms 15 . Therefore, it is of great interest to develop a support tool such as ATOPE+ 16 to assist with a nonlinear prescription, monitor readiness, and control the loading-recovery cycle to allow safe and effective doses following physiological adaptations.…”

Section: Hrvmentioning

confidence: 99%

“…The centralized secure server enables data storage and processing, as well as the generation of tailored exercise prescription according to expert rules. The architecture and usability of ATOPE+ have previously been described 16 . The registration code of the system is 1710092555522.…”

Section: Description Of Atope+ and Data Collectionmentioning

confidence: 99%

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mHealth system (ATOPE+) to support exercise prescription in breast cancer survivors: a reliability and validity, cross-sectional observational study (ATOPE study)

Postigo-Martín

Gil-Gutiérrez

Moreno-Gutiérrez

et al. 2022

Sci Rep

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Physical exercise is known to be beneficial for breast cancer survivors (BCS). However, avoiding nonfunctional overreaching is crucial in this population, as they are in physiological dysregulation. These factors could decrease their exercise capacity or facilitate nonfunctional overreaching, which can increase their risk of additional morbidities and even all-cause mortality. The focus of this study is to evaluate the reliability and validity of the ATOPE+ mHealth system to estimate autonomic balance and specific wellness parameters associated with BCS’ perceived load, thereby informing nonlinear prescriptions in individualized physical exercise programs for BCS.Twenty-two BCS were included in the reliability and validity analysis. Measures were taken for four days, including morning autonomic balance by heart rate variability, self-reported perception of recovery from exercise, sleep satisfaction, emotional distress and fatigue after exertion. Measures were taken utilizing the ATOPE+ mHealth system application. The results of these measures were compared with criterion instruments to assess validity.The reliability results indicated that the intraclass correlation coefficient (ICC) showed an excellent correlation for recovery (0.93; 95% CI 0.85–0.96) and distress (0.94, 95% CI 0.89–0.97) as well as good correlation for the natural logarithm of the mean square root differences of the standard deviation (LnRMSSD) (0.87; 95% CI 0.74–0.94). Sleep satisfaction also showed an excellent correlation with a weighted kappa of 0.83. The validity results showed no significant differences, except for fatigue. ATOPE+ is reliable and valid for remotely assessing autonomic balance, perception of recovery, sleep satisfaction and emotional distress in BCS; however, it is not for fatigue. This highlights that ATOPE+ could be an easy and efficient system used to assess readiness in BCS, and could help to improve their health by supporting the prescription of optimal and safe physical exercise. Trial registration NCT03787966 ClinicalTrials.gov, December 2019 [ATOPE project]. https://clinicaltrials.gov/ct2/show/NCT03787966.

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Section: Discussionmentioning

confidence: 99%

Section: Hrvmentioning

confidence: 99%

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mHealth system (ATOPE+) to support exercise prescription in breast cancer survivors: a reliability and validity, cross-sectional observational study (ATOPE study)

Postigo-Martín

Gil-Gutiérrez

Moreno-Gutiérrez

et al. 2022

Sci Rep

Self Cite

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“…After this, more specific physical exercises will be used. A nonlinear prescription (with daily load and frequency of sessions per week) will be determined with a mobile app (ATOPE+; Moreno‐Gutierrez et al, 2021), according to FIIT (frequency, intensity, time, and type) parameters (Campbell et al, 2019); see Table 2 that shows the ATENTO program in detail. The intensity of the aerobic and strength exercises will be controlled according to heart rate (Nilsen et al, 2018) and perceived exertion (Garnacho‐Castano et al, 2018).…”

Section: Methodsmentioning

confidence: 99%

Neurotoxicity prevention with a multimodal program (ATENTO) prior to cancer treatment versus throughout cancer treatment in women newly diagnosed for breast cancer: Protocol for a randomized clinical trial

González-Santos

Postigo-Martín

Gallart-Aragón

et al. 2021

Research in Nursing & Health

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A current challenge in breast cancer (BC) patients is how to reduce the side effects of cancer and cancer treatments and prevent a decrease in quality of life (QoL). Neurotoxic side effects, especially from chemotherapy, are present in up to 75% of women with BC, which implies a large impact on QoL. There is a special interest in the preventive possibilities of therapeutic exercise (TE) for these neurological sequelae, and the benefits of TE could be improved when it is combined with vagal activation techniques (VATs). This superiority randomized controlled trial aims to examine the feasibility and efficacy of an 8‐week multimodal intervention (ATENTO) based on moderate‐vigorous intensity and individualized TE (aerobic and strength exercises) and VAT (myofascial and breathing exercises), on neurotoxicity prevention in women with BC before starting adjuvant chemotherapy (ATENTO‐B) versus throughout adjuvant chemotherapy (ATENTO‐T). A sample of 56 women newly diagnosed with BC, as calculated with a power of 85%, will be randomly allocated into these two groups. This study could provide an impetus for the introduction of early multimodal intervention methods to prevent neurotoxicity and consequently avoid the QoL deterioration that BC patients presently suffer throughout their treatments.

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“…Furthermore, these systems can meet patients' needs by providing different exercise programs with visual or audio instructions. However, computer-based and set-top-box-based telerehabilitation systems require additional equipment [20], [21], which is neither easily available nor portable. Although telecommunications applications, such as Skype and Teams, provide the other solution for telerehabilitation, the patients in need of rehabilitation are mainly the elderly, who exhibit a low likelihood of using the aforementioned technologies because of a lack of familiarity with them, the treatment effect of telerehabilitation might be attenuated [13].…”

Section: Introductionmentioning

confidence: 99%

Development of a Smartphone-Based mHealth Platform for Telerehabilitation

Lin

Lee

et al. 2022

IEEE Trans. Neural Syst. Rehabil. Eng.

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Telerehabilitation is becoming increasingly valuable as a method for expanding medical services. The smartphone-based mHealth platform (SMPT) has been developed to provide high-quality remote rehabilitation through a smartphone and inertial measurement units. The SMPT uses smartphone as a main platform with connection to medical backend server to provide telerehabilitation. Patients would be referred to therapists to receive a tutorial of exercise technique prior to conducting their home exercise. Once patients begin their home exercises, they can report any problems instantly through the SMPT. The medical staff can adjust the exercise program according to patient feedback and the data collected by the SMPT. After completing the exercise program, patients visit their clinician for re-evaluation. A Service User Technology Acceptability Questionnaire from both medical professional and public perspective revealed a high level of agreement on enhanced care, increased accessibility, and satisfaction and a moderate level of agreement on the use of this platform as a substitute for traditional rehabilitation. Concerns about privacy and discomfort were low in the medical professional and public groups. Concerns about care personnel were also significantly different between the two groups. The SMPT is a promising system for providing telerehabilitation as an adjunct to traditional rehabilitation, which may result in improved outcomes compared with those achieved when using traditional rehabilitation alone.

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ATOPE+: An mHealth System to Support Personalized Therapeutic Exercise Interventions in Patients With Cancer

Cited by 9 publications

References 76 publications

mHealth system (ATOPE+) to support exercise prescription in breast cancer survivors: a reliability and validity, cross-sectional observational study (ATOPE study)

mHealth system (ATOPE+) to support exercise prescription in breast cancer survivors: a reliability and validity, cross-sectional observational study (ATOPE study)

Neurotoxicity prevention with a multimodal program (ATENTO) prior to cancer treatment versus throughout cancer treatment in women newly diagnosed for breast cancer: Protocol for a randomized clinical trial

Development of a Smartphone-Based mHealth Platform for Telerehabilitation

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