Atomoxetine-induced mydriasis in a child patient

Bahalı, Kayhan; İpek, Hamiyet; Yalcin, Ozhan; Örüm, Özgür

doi:10.1007/s00787-013-0491-x

Cited by 5 publications

(4 citation statements)

References 9 publications

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“…A reaction that occurs in about 2 % of patients who are poor metabolizers of the cytochrome P450 (CYP) 2D6 enzymatic pathway and in about 1 % of patients who are extensive metabolizers of CYP2D6. However, although atomoxetine has been a drug prescribed for many years, a search in PubMed (with the terms atomoxetine and mydriasis) displayed no clinical study and just two case reports (without abstract) [6,7] to support an association between atomoxetine and mydriasis The first case report simply stated that a 15-year-old naïve and healthy female adolescent developed mydriasis after treatment of ADHD with atomoxetine [6]. The second case report concerns an 8-yearold boy with ADHD who was prescribed 10 mg of atomoxetine orally once daily for a month [7].…”

Section: Discussionmentioning

confidence: 99%

Transient Mydriasis under Atomoxetine Treatment: Case Report and Brief Overview of the Literature

Haefliger¹,

Herz²

2018

Klin Monatsbl Augenheilkd

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Section: Discussionmentioning

confidence: 99%

Transient Mydriasis under Atomoxetine Treatment: Case Report and Brief Overview of the Literature

Haefliger¹,

Herz²

2018

Klin Monatsbl Augenheilkd

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“…8 Two cases of ATX-related mydriasis have also been reported. 5,6 In the first case, a 15-year-old girl developed mydriasis after a 4-week treatment of ADHD with ATX, 60 mg/day. 5 In the second case, an 8-year-old boy presented with dilated pupils on the first month of ATX treatment with a dosage of 25 mg/day and his IOP was in normal range.…”

Section: Findings and Comparisons With Similar Studiesmentioning

confidence: 99%

“…5 In the second case, an 8-year-old boy presented with dilated pupils on the first month of ATX treatment with a dosage of 25 mg/day and his IOP was in normal range. 6…”

Section: Findings and Comparisons With Similar Studiesmentioning

confidence: 99%

“…5 In addition, some ocular side effects such as accommodation problems, mydriasis, cataract, increase in intraocular pressure (IOP), and glaucoma have been reported due to these medications. 1,[5][6][7][8] Owing to its mechanism of action, MPH may cause closure of the angle and increase IOP; hence, precautions of its usage in patients with angle-closure glaucoma are needed. However, these potential ocular side effects are limited as case reports and have not been studied in pediatric age groups.…”

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confidence: 99%

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The effects of medication on intraocular pressure in children with attention deficit hyperactivity disorder: A prospective study

Guvenmez

Çubuk²,

Güneş³

2020

jptcp

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Attention deficit hyperactivity disorder (ADHD) is one of the most common psychiatric conditions in childhood. Psychopharmacological therapy is an effective treatment for ADHD. In this study, we primarily aim to investigate the effects of psychopharmacological agents on intraocular pressure (IOP) in children with ADHD. The sample included 82 children with ADHD and 36 healthy children aged between 8 and 12 years who were referred to the Department of Child and Adolescent Psychiatry in Hatay State Hospital, Hatay, Turkey. Children with ADHD were divided into two groups according to the medication used: methylphenidate (MPH) group and atomoxetine (ATX) group. Before treatment and after 1-and 6-month treatment period, IOP was measured by Goldmann applanation tonometry. There were no statistical differences in terms of age, gender, and IOP between the three groups (P > 0.05). After 1-and 6-month treatment, the IOP did not change significantly between baseline and 1 month or 6 months (P > 0.05). Children with ADHD may have an IOP similar to healthy children. Six-month treatment with MPH or ATX may not cause significant changes in IOP.

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Atomoxetine

2014

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Atomoxetine-induced mydriasis in a child patient

Cited by 5 publications

References 9 publications

Transient Mydriasis under Atomoxetine Treatment: Case Report and Brief Overview of the Literature

Transient Mydriasis under Atomoxetine Treatment: Case Report and Brief Overview of the Literature

The effects of medication on intraocular pressure in children with attention deficit hyperactivity disorder: A prospective study

Atomoxetine

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