Atomic spectrometry update—X-ray fluorescence spectrometry

Potts, Philip J.; Ellis, Andrew T.; Kregsamer, P.; Streli, Christina; Vanhoof, Christine; West, Margaret; Wobrauschek, P.

doi:10.1039/b611269m

Cited by 32 publications

(23 citation statements)

References 391 publications

(344 reference statements)

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“…This technique is based on exciting the atoms in a material by applying an X-ray beam with appropriate energy and subsequent detection of the characteristic radiation emitted, which in turn is proportional to the concentration of atoms in the material [44]. XRF has many advantages, such as a simple and rapid procedure of analysis in a large number of samples, high sensitivity and low detection limits, enabling the determination of elements concentrations in trace and ultra-trace levels [45,46]. The XRF technique has some variations depending on, among others, excitation and detection setup [46].…”

Section: Introductionmentioning

confidence: 99%

“…XRF has many advantages, such as a simple and rapid procedure of analysis in a large number of samples, high sensitivity and low detection limits, enabling the determination of elements concentrations in trace and ultra-trace levels [45,46]. The XRF technique has some variations depending on, among others, excitation and detection setup [46]. Basically, if excitation is performed under small angles relative to the sample, the technique is called Total Reflection X-Ray Fluorescence (TXRF), if incident beam is too small (order of microns), the technique is called Micro-X Ray Fluorescence (μ-XRF).…”

Section: Introductionmentioning

confidence: 99%

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Trace elements as tumor biomarkers and prognostic factors in breast cancer: a study through energy dispersive x-ray fluorescence

Piacenti-Silva

Soave²,

Ribeiro‐Silva³

et al. 2012

BMC Res Notes

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BackgroundThe application and better understanding of traditional and new breast tumor biomarkers and prognostic factors are increasing due to the fact that they are able to identify individuals at high risk of breast cancer, who may benefit from preventive interventions. Also, biomarkers can make possible for physicians to design an individualized treatment for each patient. Previous studies showed that trace elements (TEs) determined by X-Ray Fluorescence (XRF) techniques are found in significantly higher concentrations in neoplastic breast tissues (malignant and benign) when compared with normal tissues. The aim of this work was to evaluate the potential of TEs, determined by the use of the Energy Dispersive X-Ray Fluorescence (EDXRF) technique, as biomarkers and prognostic factors in breast cancer.MethodsBy using EDXRF, we determined Ca, Fe, Cu, and Zn trace elements concentrations in 106 samples of normal and breast cancer tissues. Cut-off values for each TE were determined through Receiver Operating Characteristic (ROC) analysis from the TEs distributions. These values were used to set the positive or negative expression. This expression was subsequently correlated with clinical prognostic factors through Fisher’s exact test and chi-square test. Kaplan Meier survival curves were also evaluated to assess the effect of the expression of TEs in the overall patient survival.ResultsConcentrations of TEs are higher in neoplastic tissues (malignant and benign) when compared with normal tissues. Results from ROC analysis showed that TEs can be considered a tumor biomarker because, after establishing a cut-off value, it was possible to classify different tissues as normal or neoplastic, as well as different types of cancer.The expression of TEs was found statistically correlated with age and menstrual status. The survival curves estimated by the Kaplan-Meier method showed that patients with positive expression for Cu presented a poor overall survival (p < 0.001).ConclusionsThis study suggests that TEs expression has a great potential of application as a tumor biomarker, once it was revealed to be an effective tool to distinguish different types of breast tissues and to identify the difference between malignant and benign tumors. The expressions of all TEs were found statistically correlated with well-known prognostic factors for breast cancer. The element copper also showed statistical correlation with overall survival.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Trace elements as tumor biomarkers and prognostic factors in breast cancer: a study through energy dispersive x-ray fluorescence

Piacenti-Silva

Soave²,

Ribeiro‐Silva³

et al. 2012

BMC Res Notes

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“…No entanto, essas regiões podem ser correlacionadas com propriedades importantes para análise qualitativa ou mesmo quantitativa, quando os dados são tratados com quimiometria. 5,[17][18][19] Obtidos os espectros, realizou-se a atribuição dos picos, utilizando-se principalmente as energias associadas às linhas Ka, características de cada elemento químico. De forma geral, foram detectados quatro elementos comumente encontrados na matriz de garrafas PET: S, Fe, Cu e Sb.…”

Section: Resultsunclassified

Quantificação de antimônio em garrafas de politereftalato de etileno (PET) brasileiras por fluorescência de raios-X e avaliação quimiométrica para verificar a presença de pet reciclado através do teor de ferro

Shimamoto¹,

Kazitoris²,

Lima³

et al. 2011

Quím. Nova

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“…A powerful method for investigating elemental composition and distribution is X-ray fluorescence spectroscopy (XRF) [88] and imaging (2D [79][80][81]89] and 3D [90]). Excellent spatial resolutions of 0.5-1 lm range for hard X-rays ([3 keV) and ca.…”

Section: Synchrotron X-raymentioning

confidence: 99%

Space-Resolved Profiling Relevant in Heterogeneous Catalysis

Urakawa

Baiker

2009

Top Catal

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Knowledge of gradients involved in chemical processes, such as heterogeneously catalyzed reactions, on molecular as well as reactor scale is of paramount importance for understanding and optimizing such processes. This review highlights and discusses recent advances in spatially resolved methods for the detection of chemical (structural) and temperature gradients, with particular focus on in situ methods.

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Atomic spectrometry update—X-ray fluorescence spectrometry

Cited by 32 publications

References 391 publications

Trace elements as tumor biomarkers and prognostic factors in breast cancer: a study through energy dispersive x-ray fluorescence

Trace elements as tumor biomarkers and prognostic factors in breast cancer: a study through energy dispersive x-ray fluorescence

Quantificação de antimônio em garrafas de politereftalato de etileno (PET) brasileiras por fluorescência de raios-X e avaliação quimiométrica para verificar a presença de pet reciclado através do teor de ferro

Space-Resolved Profiling Relevant in Heterogeneous Catalysis

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