Atomic Spectrometry Update: review of advances in elemental speciation

Clough, Robert; Harrington, Chris F.; Hill, Steve J.; Madrid, Yolanda; Tyson, Julian F.

doi:10.1039/d1ja90026a

Cited by 14 publications

(22 citation statements)

References 197 publications

(237 reference statements)

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“…Elemental speciation tracks analytes using their constituent atoms, 1 offering several attributes complementary to molecular detection: (1) compounds containing a targeted element are detected without regard for the compounds' structures. (2) The elemental selectivity and matrix tolerance improve detection for compounds of interest in the presence of concomitant molecules within a complex sample.…”

Section: ■ Introductionmentioning

confidence: 99%

High-Resolution Elemental Mass Spectrometry Using LC-ICP-Nanospray-Orbitrap for Simultaneous and Species-Independent Quantitation of Fluorinated and Chlorinated Compounds

et al. 2022

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Simultaneous elemental detection of F and Cl offers quantitation of fluorinated and chlorinated compounds and their transformation products without compound-specific standards. Despite wide-ranging applications, this capability has been hindered by fundamental and technical shortcomings of current inductively coupled plasma (ICP)-MS methods in ion formation and isobaric interference elimination. These hurdles are alleviated here via a chemical ionization method. Fluorine and chlorine in analytes are first converted to HF and HCl by an ICP with post-plasma recombination and subsequently react with barium-containing ions supplied by a nanospray, yielding BaF + and BaCl + as elemental reporter ions. Notably, the method is readily interfaced to an Orbitrap MS which eliminates isobaric interferences at resolving powers as low as 35,000, far greater than that of current ICP−MS instruments. Moreover, the instrument is easily reverted to the ESI-MS mode for complementary molecular characterization. To demonstrate analytical capabilities, a workflow for rapid quantitation of compounds separated by reversed-phase liquid chromatography is developed using a species-independent calibration. The independent F and Cl measurements agree with each other, providing recoveries of >90% and LODs of 8−12 pmol Cl and 5− 12 pmol F on the column. The workflow along with LC-ESI-MS on the same instrument is then applied to identify and quantify invitro drug metabolites, yielding total drug-related material recoveries of >80% and quantitation of minor metabolites summing to 8% of the total drug-related compounds. These results highlight the strengths of simultaneous F and Cl speciation for rapid quantitation with applications in early drug development.

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Section: ■ Introductionmentioning

confidence: 99%

High-Resolution Elemental Mass Spectrometry Using LC-ICP-Nanospray-Orbitrap for Simultaneous and Species-Independent Quantitation of Fluorinated and Chlorinated Compounds

et al. 2022

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“…It should be read in conjunction with the previous review 1 and the other related reviews in the series. [2][3][4][5][6] A critical approach to the selection of material has been adopted, with only novel developments in instrumentation, techniques and methodology being included.…”

Section: Glossary Of Abbreviationsmentioning

confidence: 99%

Atomic spectrometry update: review of advances in atomic spectrometry and related techniques

Evans

Pisonero

Smith

et al. 2022

J. Anal. At. Spectrom.

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“…Selenium speciation in biota has aroused great interest in recent years; however, there is a lack of information about the chemical form of Se in (sea)birds. The literature concerning Se speciation in birds ,− has been almost exclusively focused on experimental birds and broilers. − , Most of these studies compared the growth performance, meat yield, and antioxidant status in broilers depending on the Se dietary sources. ,,− In general terms, a supplementation with organic forms, usually selenomethionine, is more efficiently incorporated than that with selenite, also leading to improved growth and antioxidant status. ,, Selenium speciation studies in experimental birds (by high-performance liquid chromatography coupled to inductively coupled plasma mass spectrometry (HPLC-ICP-MS)) reveal a dissimilar metabolization of inorganic and organic Se sources, as well as an association of Se with high- and medium-molecular-weight species. ,, Only a few investigations considered Se speciation in wild birds, these being limited to the identification of its association with Hg. ,, In this respect, Hg bound to tetraselenolate (Hg(SeR) 4 ) likely acts as a precursor of tiemannite (HgSe). , This latter compound is considered the final product of methylmercury (MeHg) detoxification .…”

Section: Introductionmentioning

confidence: 99%

“…26 are likely due to their high position in the marine food web and their long lifespan. 16,18 Selenium speciation in biota has aroused great interest in recent years; 27 however, there is a lack of information about the chemical form of Se in (sea)birds. The literature concerning Se speciation in birds 26,28−33 has been almost exclusively focused on experimental birds and broilers.…”

Section: ■ Introductionmentioning

confidence: 99%

First Time Identification of Selenoneine in Seabirds and Its Potential Role in Mercury Detoxification

Hanafi

Pedrero

Ouerdane

et al. 2022

Environ. Sci. Technol.

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Birds are principally exposed to selenium (Se) through their diet. In long-lived and top predator seabirds, such as the giant petrel, extremely high concentrations of Se are found.Selenium speciation in biota has aroused great interest in recent years, however there is a lack of information about the chemical form of Se in (sea)birds. The majority of publications focus on the growth performance and antioxidant status in broilers in relation to Se dietary supplementation. The present work combines elemental and molecular mass spectrometry for the characterization of Se species in wild (sea)birds. A set of 8 giant petrel (Macronectes sp.) individuals of a wide age range from the Southern Ocean was studied. Selenoneine (2-selenyl-N,N,N-trimethyl-L-histidine), a Se-analog of ergothioneine was identified for the first time in wild avian species. This novel Se-compound, previously reported in fish, constitutes the major Se species in the water-soluble fraction of all the internal tissues and blood samples analyzed.The levels of selenoneine found in giant petrels are the highest reported in animal tissues until now, supporting the trophic transfer in the marine food web. The characterization of selenoneine in brain, where it represents between 78 and 88% of the total Se, suggests a crucial role in the nervous system. The dramatic diminishment of selenoneine (from 70 to 5 %) with the increase of Hg concentrations in the liver strongly supports the hypothesis of its key role in Hg detoxification.

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Atomic Spectrometry Update: review of advances in elemental speciation

Abstract: This review covers advances in elemental speciation by a range of coupled techniques, including HPLC-ICP-MS, HPLC-HG-AFS and GC-ICP-MS.

Cited by 14 publications

References 197 publications

High-Resolution Elemental Mass Spectrometry Using LC-ICP-Nanospray-Orbitrap for Simultaneous and Species-Independent Quantitation of Fluorinated and Chlorinated Compounds

High-Resolution Elemental Mass Spectrometry Using LC-ICP-Nanospray-Orbitrap for Simultaneous and Species-Independent Quantitation of Fluorinated and Chlorinated Compounds

Atomic spectrometry update: review of advances in atomic spectrometry and related techniques

First Time Identification of Selenoneine in Seabirds and Its Potential Role in Mercury Detoxification

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