Atomic insights into the signaling landscape ofE. coliPhoQ Histidine Kinase from Molecular Dynamics simulations
Symela Lazaridi,
Jing Yuan,
Thomas Lemmin
Abstract:Bacteria rely on two-component systems to sense environmental cues and regulate gene expression for adaptation. The PhoQ/PhoP system exemplifies this crucial role, playing a key part in sensing magnesium (Mg2+) levels, antimicrobial peptides, mild acidic pH, osmotic upshift, and long-chain unsaturated fatty acids, promoting virulence in certain bacterial species. However, the precise details of PhoQ activation remain elusive. To elucidate PhoQ's signaling mechanism at atomic resolution, we combined AlphaFold2 … Show more
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