Atom-Economical Syntheses of Dihydropyrroles Using Flavin–Iodine-Catalyzed Aerobic Multistep and Multicomponent Reactions

Abstract

Herein, we report facile, atom-economical syntheses of multisubstituted 2,3-dihydropyrroles using flavin–iodine-catalyzed aerobic oxidative multistep transformations of chalcones with β-enamine ketones or 1,3-dicarbonyl compounds and amines. Exploiting coupled flavin–iodine catalysis, the multistep reaction, including C–C and C–N bond formation, is promoted only by the consumption of O2 (1 atm), thus allowing aerobic oxidative synthesis that generates green H2O as the only waste.