Atmospheric-Pressure Plasma Spray Deposition of Silver/HMDSO Nanocomposite on Polyamide 6,6 with Controllable Antibacterial Activity

Ribeiro, Ana Isabel; Modić, Martina; Cvelbar, Uroš; Dinescu, G.; Mitu, B.; Nikiforov, Anton; Leys, Christophe; Kuchakova, I.; Souto, A. Pedro; Zille, Andrea

doi:10.14504/ajr.7.3.1

Cited by 8 publications

(6 citation statements)

References 19 publications

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“…In addition to the superior AgNPs adhesion in DBD plasma treated samples, also superior adsorption of chitosan in DBD plasma-treated was observed (for Ch+AgNPs samples, 25.2 and 32.0 At%). DBD plasma treatment is able to change the surface properties of PA66 fabrics, providing more roughness surfaces and newly reactive oxygen species [13]. The deconvolution spectra of C1s, N1s, O1s, and Ag3d highlighted the chemical modifications of PA66 surface due to DBD plasma treatment and chitosan layers (Tables 2 and 3).…”

Section: Xpsmentioning

confidence: 95%

DBD Plasma treatment and chitosan layers - A green method for stabilization of silver nanoparticles on polyamide 6,6

Ribeiro

Modić

Cvelbar

et al. 2020

Proceedings of the First International Conference on “Green” Polymer Materials 2020

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The addition of silver nanoparticles (AgNPs) to biomedical textiles can be of great interest to protect the materials against microorganisms and prevent their spread. However, the human and environmental over-exposure to AgNPs is leading to numerous concerns due to their toxicity. In this work, AgNPs were stabilized onto polyamide 6.6 fabrics (PA66) through atmospheric dielectric barrier discharge (DBD) plasma treatment and the use of chitosan (Ch) layers applied by spray. DBD plasma treatment revealed a crucial role in AgNPs adhesion (4.8 and 6.3 At%). A first layer of Ch decreased the AgNPs adhesion in both untreated and DBD plasma-treated samples but treated samples show higher concentration (1.7 and 4.1 At%). The antibacterial activity was evaluated against Staphylococcus aureus and Escherichia coli after 2 and 24 h, showing a superior action in all samples with DBD plasma treatment after 24 h. The Ch in the first layers of the composites delayed the antimicrobial action of the samples but it also may enhance antimicrobial action. The obtained coatings will allow the development of novel and safe wound dressings with improved AgNPs deposition, controlled ions released and consequently, manage the antimicrobial performance and minimize the AgNPs side effects.

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Section: Xpsmentioning

confidence: 95%

DBD Plasma treatment and chitosan layers - A green method for stabilization of silver nanoparticles on polyamide 6,6

Ribeiro

Modić

Cvelbar

et al. 2020

Proceedings of the First International Conference on “Green” Polymer Materials 2020

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“…The synthesis process defines the physicochemical properties of nanoparticles, which governs their size, shape, surface charge and oxidation state. [75][76][77] These properties will considerably influence the interactions between MNPs and conjugated agents and, consequently, their antimicrobial performance and cytotoxicity.…”

Section: Metal Nanoparticle Synthesismentioning

confidence: 99%

Synergistic Effects Between Metal Nanoparticles and Commercial Antimicrobial Agents: A Review

Ribeiro

Dias

Zille

2022

ACS Appl. Nano Mater.

113

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Nanotechnology has expanded into a broad range of clinical applications. In particular, metal nanoparticles (MNPs) display unique antimicrobial properties, a fundamental function of novel medical devices. Combining MNPs with commercial antimicrobial drugs (e. g., antibiotics, antifungals and antivirals) may offer several opportunities to overcome some disadvantages of their individual use and enhance effectiveness. MNPs-conjugates display multiple advantages. As drug delivery systems, the conjugates can extend the circulation of the drugs in the body, facilitate intercellular targeting, improve drug stabilization, and possess superior delivery. Concomitantly, they reduce the required drug dose, minimize toxicity and broaden the antimicrobial spectrum. In this work, the common strategies to combine MNPs with clinically used antimicrobial agents are underscored. Furthermore, a comprehensive survey about synergistic antimicrobial effects, mechanism of action and cytotoxicity is depicted. SilverAntimicrobial, drug deliver, anticancer, anti-angiogenic and biosensors 46,47 Gold Drug delivery, catalyst for medical therapy, antimicrobial conjugations, anticancer, gene therapy and diagnostic 48,49 Copper and copper oxide Antimicrobial and catalysis 50, 51 Iron and iron oxideAnticancer therapy, magnetic resonance imaging, targeted drug delivery and cell separation catalysis [52][53][54] Zinc oxide Personal care products, coatings, drug delivery, anticancer and antimicrobial 55, 56Aluminum oxide Drug delivery, biosensing, cancer therapy, antimicrobial, biomolecular preservation, immunotherapy 57 Titanium oxideDrug delivery, photodynamic therapy, cell imaging, biosensors, and genetic engineering, antimicrobial 58,59 Platinum Biomedical devices, anticancer therapies, cardiovascular diseases, bioimaging, nanozymes, biosensors, antimicrobial 60, 61 PalladiumPhotothermal agents, photoacoustic agents, antimicrobial, anticancer, gene/drug carriers, prodrug activators and biosensors 62,63 Scheme 1. MNPs used in biomedical applications. Silver Nanoparticles (AgNPs)AgNPs are the most prevalent inorganic nanoparticles applied as antimicrobial agent. AgNPs have demonstrated high antimicrobial activity comparable to Ag ionic form. However, several concerns have emerged regarding their cytotoxicity. The toxicity mechanisms, long-term accumulation effects and dose-response relationship are still grievously unknown. 64 Gold Nanoparticles (AuNPs)AuNPs are extremely valuable in developing antibacterial agents due to their low toxicity, high propensity for functionalization, eclectic effects, easy detection and photothermal activity. AuNPs per se possess very low antimicrobial activity, but numerous studies on the antimicrobial activity of AuNPs conjugated with small molecules, such as drugs, vaccines and antibodies, have been reported.

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“…1,[12][13][14] Ag-NPs are blended with polyamides such as Nylon-6 to obtain antimicrobial nanocomposites to manufacture textiles, 15 medical devices, 16 membranes for air filters and water purification, [17][18][19] among others. Commonly, these nanocomposites are produced by plasma deposition of Ag-NPs, stabilizing agents, solution spray, and chemical reduction 18,[20][21][22] ; solution mixing 23 ; melt mixing, 24 melt mixingultrasound-assisted surface plasma activation 25 and melt mixing-silver acetate thermal reduction. 26,27 However, one of the most critical problems in processing these polymer nanocomposites with Ag-NPs is the dispersion of the nanoparticles in the polymer.…”

Section: Introductionmentioning

confidence: 99%

Microwave dielectric heating affects the in‐situ polymerization process of Nylon‐6/Ag‐NPs hybrid polymer nanocomposite

Mendoza-Tolentino¹,

Romero-Zúñiga

Reyes³

et al. 2023

J of Applied Polymer Sci

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In this work, the microwave synthesis of Nylon-6 hybrid polymeric nanocomposite (HPNC) was studied by the polymerization of ε-caprolactam, 6-aminocaproic acid, and 2% wt of silver nanoparticles (Ag-NPs). It was determined that the dielectric heating (DH) of the Ag-NPs controls the thermal behavior of the HPNCs synthesis and triggers the chemical reaction between Ag-NPs and the Nylon-6 molecules. Such reaction promotes their coating with the polymer and their precipitation, which affects the agitation of the reaction mixture, and results in broader molecular weight distribution and three HPNC populations. Usually, the power output effect in these processes is thermal as it accelerates their heating rate. Still, for HPNCs, higher output reduces the agglomerate size of the Ag-NPs and accelerates their precipitation. At power up to 600 W, the DH of the Ag-NPs causes the explosion of the reaction vials.The antimicrobial activity of the HPNCs against P. aeruginosa is almost 100% effective at 180 min of exposure; therefore, this microwave synthesis process is suitable for producing antimicrobial HPNCs.

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Atmospheric-Pressure Plasma Spray Deposition of Silver/HMDSO Nanocomposite on Polyamide 6,6 with Controllable Antibacterial Activity

Cited by 8 publications

References 19 publications

DBD Plasma treatment and chitosan layers - A green method for stabilization of silver nanoparticles on polyamide 6,6

DBD Plasma treatment and chitosan layers - A green method for stabilization of silver nanoparticles on polyamide 6,6

Synergistic Effects Between Metal Nanoparticles and Commercial Antimicrobial Agents: A Review

Microwave dielectric heating affects the in‐situ polymerization process of Nylon‐6/Ag‐NPs hybrid polymer nanocomposite

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