Atmospheric pressure plasma assisted immobilization of hyaluronic acid on tissue engineering PLA-based scaffolds and its effect on primary human macrophages

Kudryavtseva, Valeriya; Stankevich, Ksenia S.; Gudima, Alexandu; Kibler, Elina; Zhukov, Yu. M.; Bolbasov, E. N.; Malashicheva, Anna; Zhuravlev, M. V.; Riabov, Vladimir; Liu, Tengfei; Филимонов, В. Д.; Ремнев, Г. Е.; Klüter, Harald; Kzhyshkowska, Julia; Tverdokhlebov, Sergei I.

doi:10.1016/j.matdes.2017.04.079

Cited by 52 publications

(32 citation statements)

References 78 publications

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“…IL‐2 regulates the powerful IL‐6‐mediated inflammatory response, making it an important immunomodulatory lever controlled by ECM . VEGF promotes angiogenesis, and conditioned media of macrophages cultured on polylactic acid (PLA)‐based scaffolds with immobilized high‐MW HA stimulated tube formation in human umbilical vascular endothelial cell cultures . These effects are mediated primarily through cellular adhesion to HA via CD44 receptors, which are expressed on both innate and adaptive immune cells and can be crosslinked by binding high‐MW HA, but not low‐MW HA .…”

Section: Immunomodulation By Naturally Derived Ecmsmentioning

confidence: 99%

Extracellular Matrix‐Based Strategies for Immunomodulatory Biomaterials Engineering

Rowley

Nagalla

Wang

et al. 2019

Adv Healthcare Materials

128

123

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The extracellular matrix (ECM) is a complex and dynamic structural scaffold for cells within tissues and plays an important role in regulating cell function. Recently it has become appreciated that the ECM contains bioactive motifs that can directly modulate immune responses. This review describes strategies for engineering immunomodulatory biomaterials that utilize natural ECM‐derived molecules and have the potential to harness the immune system for applications ranging from tissue regeneration to drug delivery. A top‐down approach utilizes full‐length ECM proteins, including collagen, fibrin, or hyaluronic acid‐based materials, as well as matrices derived from decellularized tissue. These materials have the benefit of maintaining natural conformation and structure but are often heterogeneous and encumber precise control. By contrast, a bottom‐up approach leverages immunomodulatory domains, such as Arg–Gly–Asp (RGD), matrix metalloproteinase (MMP)‐sensitive peptides, or leukocyte‐associated immunoglobulin‐like receptor‐1(LAIR‐1) ligands, by incorporating them into synthetic materials. These materials have tunable control over immune cell functions and allow for combinatorial approaches. However, the synthetic approach lacks the full natural context of the original ECM protein. These two approaches provide a broad range of engineering techniques for immunomodulation through material interactions and hold the potential for the development of future therapeutic applications.

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Section: Immunomodulation By Naturally Derived Ecmsmentioning

confidence: 99%

Extracellular Matrix‐Based Strategies for Immunomodulatory Biomaterials Engineering

Rowley

Nagalla

Wang

et al. 2019

Adv Healthcare Materials

128

123

View full text Add to dashboard Cite

show abstract

“…The main drawbacks of polylactide materials are hydrophobicity and a lack of specific functional groups to promote cell adhesion and growth on its surface. A number of methods to modify polylactide surface properties, such as chemical treatment and high‐energy methods, like plasma treatment and laser‐ and γ‐irradiation, are reported . To increase polylactide biocompatibility, chitosan coatings are widely proposed.…”

Section: Introductionmentioning

confidence: 99%

Coating of polylactide films by chitosan: Comparison of methods

Демина

Frolova

Istomin

et al. 2019

J of Applied Polymer Sci

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Control over biomaterials surface characteristics through surface modification or deposition of coatings is one of the key aspects of tissue engineering. This work was aimed to evaluate an effectiveness of various methods of chitosan-coating formations onto polylactide films using a number of techniques, such as vacuum deposition by electron-beam sputtering, chemical entrapment method, and electrospray procedure. Differently coated films were studied in terms of surface morphology (scanning electron and atomic-force microscopy), chemical structure (FTIR and X-ray photoelectron spectroscopy), and hydrophilic/hydrophobic balance (goniometry). The effect of coating technique on homogeneity of chitosan distribution over the substrate surface was evaluated using genipin and fluorescein isothiocyanate labeling as well as FTIR-microscopy.

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“…In the last few years, gas plasma treatments have been extensively used to modify biomaterials for tissue engineering applications [10,11]. In particular, plasma surface activation process employs gases, such as oxygen or argon, which dissociate and react with the surface and used to create additional functional groups on the surface that can be recognized as adhesion sites for surrounding cells [12][13][14][15], whereas N 2 and NH 3 gases should be used for treatments in which it is possible to incorporate both nitrogen-containing groups [16,17].…”

Section: Introductionmentioning

confidence: 99%

Functionalization of 3D Polylactic Acid Sponge Using Atmospheric Pressure Cold Plasma

Gatti

D’Angelo

Errahali

et al. 2019

International Journal of Polymer Science

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The deposition of organic functionalities on biomaterials to immobilize biomolecules is a research area of great interest in the medical field. The surface functionalization of a 3D porous scaffolds of PDLLA with carboxyl (-COOH) and amino (-NH2) groups by cold plasma treatment at atmospheric pressure is described in this paper. Two methods of continuous and pulsed plasma deposition were compared to assess the degree of functionalization of the internal porous 3D scaffold. In particular, the pulsed plasma treatment was found to functionalize uniformly not only the sample surface but also inside the open cavities thanks to its permeability and diffusion in the porous 3D scaffold. The species developed in the plasma were studied by optical emission spectroscopy (OES) technique, while the functionalization of the sponges was evaluated by the Diffuse Reflectance Fourier-Transform Infrared Spectroscopy (DR-FTIR) technique using also the adsorption of ammonia (NH3) and deuterated water (D2O) probe molecules. The functional groups were deposited only on the front of the sponge, then the structural characterization of both front and back of the sponge has demonstrated the uniform functionalization of the entire scaffold.

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Atmospheric pressure plasma assisted immobilization of hyaluronic acid on tissue engineering PLA-based scaffolds and its effect on primary human macrophages

Cited by 52 publications

References 78 publications

Extracellular Matrix‐Based Strategies for Immunomodulatory Biomaterials Engineering

Extracellular Matrix‐Based Strategies for Immunomodulatory Biomaterials Engineering

Coating of polylactide films by chitosan: Comparison of methods

Functionalization of 3D Polylactic Acid Sponge Using Atmospheric Pressure Cold Plasma

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