Atmospheric pollution: influence on hospital admissions in paediatric rheumatic diseases

Vidotto, J P; Pereira, Luiz Alberto Amador; Braga, Alfésio Luı́s Ferreira; Silva, C A; Sallum, Adriana Maluf Elias; Campos, Lúcia Maria Arruda; Martins, Lourdes Conceição; Farhat, Sylvia Costa Lima

doi:10.1177/0961203312437806

Cited by 49 publications

(45 citation statements)

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“…A recent time-series study evaluated the influence of exposure to air pollution on the daily number of hospitalizations due to the exacerbation of disease activity of 7 pediatric rheumatic diseases (including juvenile-onset SLE) from January 2000 to December 2007. The authors found, for an IQR of SO 2 , an increase of 1.98% (95% CI 0.25-3.69) in the number of hospital admissions due to acute outbursts of the diseases studied after 14 days of exposure (4). It was observed that there was a lag effect of 2 weeks after exposure, which remained for 4 days (lag 14 to lag 17).…”

Section: Discussionmentioning

confidence: 94%

“…In this regard, this is a major public health hazard in large cities (2)(3)(4), and children and adolescents are susceptible to the effects of air pollution. However, there are few studies evaluating the association between exposure to air pollutants and autoimmune diseases in this population (4,5), and to our knowledge no study has assessed the influence of air pollutants on the disease activity of juvenile-onset systemic lupus erythematosus (SLE) patients.…”

Section: Introductionmentioning

confidence: 99%

“…However, there are few studies evaluating the association between exposure to air pollutants and autoimmune diseases in this population (4,5), and to our knowledge no study has assessed the influence of air pollutants on the disease activity of juvenile-onset systemic lupus erythematosus (SLE) patients.…”

Section: Introductionmentioning

confidence: 99%

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Exposure to Air Pollutants and Disease Activity in Juvenile‐Onset Systemic Lupus Erythematosus Patients

Fernandes

Silva

Braga

et al. 2015

Arthritis Care & Research

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Objective. To investigate the association between exposure to air pollutants in the Sao Paulo metropolitan area and disease activity in juvenile-onset systemic lupus erythematosus (SLE) patients. Methods. A longitudinal panel study based on 409 consecutive visits of juvenile-onset SLE patients living in the Sao Paulo metropolitan area was carried out. Disease activity was evaluated in accordance with the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K), and the patients were divided into 2 groups: those with SLEDAI scores £8 and those with SLEDAI scores >8. Daily concentrations of inhaled particulate matter (PM 10 ), sulfur dioxide, nitrogen dioxide (NO 2 ), ozone, and carbon monoxide (CO) were evaluated on the 21 days preceding the medical visits. A generalized estimation equation model was used to assess the impact of these measurements on SLEDAI-2K scores, considering the fixed effects for repetitive measurements. The models were adjusted for erythrocyte sedimentation rate, corticosteroid use (daily and cumulative doses), antimalarial use, the use of immunosuppressive agents, the presence of infection 20 days preceding the medical appointment, and the minimum temperature and relative humidity outdoors. Results. PM 10 , NO 2 , and CO were risk factors for juvenile-onset SLE disease activity (SLEDAI-2K score >8) approximately 2 weeks after exposure. A 13.4 mg/m 3 increase in the PM 10 moving average (from lag 12 to lag 15) was associated with a 34% increase (95% confidence interval 7.0-68.0) in the risk of a SLEDAI-2K score >8. Conclusion. This is the first study to show that exposure to inhaled pollutants may increase the risk of disease activity in children with juvenile-onset SLE in a large urban center.

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

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Exposure to Air Pollutants and Disease Activity in Juvenile‐Onset Systemic Lupus Erythematosus Patients

Fernandes

Silva

Braga

et al. 2015

Arthritis Care & Research

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“…Oxidative stress and inflammation induced by inhaled pollutants may lead to acute and chronic effects in the respiratory system, chronic inflammatory diseases such as cardiovascular, neurodegenerative and auto-immune disorders 15,16,17,18,19,20 .…”

Section: Introductionmentioning

confidence: 99%

“…, NO 2 , SO 2 , CO e O 3 foram associadas com aumentos de 18,9% (IC95%: 11,5), 19% (IC95%: 8,6), 14,4% (IC95%: 6,[5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]4), 16,5% (IC95%: 8,[9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] …”

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Air pollution and children's health: sickle cell disease

et al. 2015

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The hallmarks of sickle cell disease are anemia and vasculopathy. The aim of this study was to assess the association between air pollution and children's emergency room visits of sickle cell patients. We adopted a case-crossover design. Daily counts of children's and adolescents' sickle cell disease emergency room visits from the pediatric emergency unit in São Paulo, Brazil, were evaluated from September 1999 to December 2004, matching by temperature, humidity and controlling for day of the week. Interquartile range increases of the four-day moving averages of PM10, NO2, SO2, CO, and O3 were associated with increases of 18.9% (95%CI: 11.2-26.5), 19% (95%CI: 8.3-29.6), 14.4% (95%CI: 6.5-22.4), 16,5% (95%CI: 8.9-24.0), and 9.8% (95%CI: 1.1-18.6) in total sickle cell emergency room visits, respectively. When the analyses were stratified by pain, PM10 was found to be 40.3% higher than in sickle cell patients without pain symptoms. Exposure to air pollution can affect the cardiovascular health of children and may promote a significant health burden in a sensitive group.

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Bacteria Elimination and SO₂ Filtration Using Spacer Fabric Loaded With Natural Zeolite‐Nanosilver Composites

SHIRMOHAMMADI-BAHADORAN

Montazer

Dolatabadi

et al. 2018

CLEAN Soil Air Water

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A spacer polyethylene terephthalate (PET) fabric is produced for SO2 elimination along with antibacterial properties as textile filter. The silver nanoparticles (AgNPs) are first in‐situ synthesized on natural zeolite (Z) by wet chemical reduction using silver nitrate and sodium borohydride at room temperature. The prepared composite powder is characterized by energy dispersive X‐ray diffraction, field emission scanning electron microscopy, and transmission electron microscopy. Z/AgNPs powder is uniformly fabricated on the spacer polyester fabric through a new electro‐deposition method. It is then cured at 160 °C for 3 min and named PET‐Z/AgNPs. SO2 adsorption of PET‐Z/AgNPs is confirmed using a gas analyzer. The ability of the treated fabric to eliminate airborne Pseudomonas aeruginosa, a Gram‐negative bacterium, and Staphylococcus aureus, a Gram‐positive bacterium, is also evaluated using the modified shake flask method (AATCC‐100). No bacterial growth is observed on PET‐Z/AgNPs after 2 h. Furthermore, the breakthrough time of the treated fabric for SO2 with 5 ppm concentration was 12 min at room temperature. In addition, the treated 3D filter fabric shows suitable air permeability for application in air filtration systems.

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Atmospheric pollution: influence on hospital admissions in paediatric rheumatic diseases

Abstract: This study is the first to demonstrate a delayed association between SO(2) and PRD outburst, suggesting that oxidative stress reaction could trigger the inflammation of these diseases.

Cited by 49 publications

References 45 publications

Exposure to Air Pollutants and Disease Activity in Juvenile‐Onset Systemic Lupus Erythematosus Patients

Exposure to Air Pollutants and Disease Activity in Juvenile‐Onset Systemic Lupus Erythematosus Patients

Air pollution and children's health: sickle cell disease

Bacteria Elimination and SO₂ Filtration Using Spacer Fabric Loaded With Natural Zeolite‐Nanosilver Composites

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Atmospheric pollution: influence on hospital admissions in paediatric rheumatic diseases

Abstract: This study is the first to demonstrate a delayed association between SO(2) and PRD outburst, suggesting that oxidative stress reaction could trigger the inflammation of these diseases.

Cited by 49 publications

References 45 publications

Exposure to Air Pollutants and Disease Activity in Juvenile‐Onset Systemic Lupus Erythematosus Patients

Exposure to Air Pollutants and Disease Activity in Juvenile‐Onset Systemic Lupus Erythematosus Patients

Air pollution and children's health: sickle cell disease

Bacteria Elimination and SO2 Filtration Using Spacer Fabric Loaded With Natural Zeolite‐Nanosilver Composites

Contact Info

Product

Resources

About

Bacteria Elimination and SO₂ Filtration Using Spacer Fabric Loaded With Natural Zeolite‐Nanosilver Composites