We derive predictions for the Nadir angle (θ n ) dependence of the ratio N µ − /N µ + of the rates of the µ− and µ + multi-GeV events, and for the µ − −µ + event rate asymmetry, INO, etc.) in the case of 3-neutrino oscillations of the atmospheric ν µ and ν µ , driven by one neutrino mass squared difference,is shown to be particularly sensitive to the Earth matter effects in the atmospheric neutrino oscillations, and thus to the values of sin 2 θ 13 and sin 2 θ 23 , θ 13 and θ 23 being the neutrino mixing angle limited by the CHOOZ and Palo Verde experiments and that responsible for the dominant atmospheric ν µ → ν τ (ν µ →ν τ ) oscillations. It is also very sensitive to the type of neutrino mass spectrum which can be with normal (∆m 2 31 > 0) or with inverted (∆m 2 31 < 0) hierarchy. We find that for sin 2 θ 23 > ∼ 0.50, sin 2 2θ 13 > ∼ 0.06 and |∆m 2 31 | = (2− 3)× 10 −3 eV 2 , the Earth matter effects produce a relative difference between the integrated asymmetriesĀ µ − µ + andĀ 2ν µ − µ + in the mantle (cos θ n = 0.30− 0.84) and core (cos θ n = 0.84−1.0) bins, which is bigger in absolute value than approximately ∼ 15%, can reach the values of (30 − 35)%, and thus can be sufficiently large to be observable. The sign of the indicated asymmetry difference is anticorrelated with the sign of ∆m 231 . An observation of the Earth matter effects in the Nadir angle distribution of the asymmetry A µ − µ + (ratio N µ − /N µ + ) would clearly indicate that sin 2 2θ 13 > ∼ 0.06 and sin 2 θ 23 > ∼ 0.50, and would lead to the determination of the sign of ∆m 2 31 .