Atmospheric microplastic and nanoplastic: The toxicological paradigm on the cellular system

Choudhury, Anmol; Simnani, Faizan Zarreen; Singh, Dibyangshee; Patel, Paritosh; Sinha, Adrija; Nandi, Aditya; Ghosh, Aishee; Saha, Utsa; Kumari, Khushboo; Jaganathan, Saravana Kumar; Kaushik, Nagendra Kumar; Panda, Pritam Kumar; Suar, Mrutyunjay; Verma, Suresh K.

doi:10.1016/j.ecoenv.2023.115018

Cited by 21 publications

(5 citation statements)

References 242 publications

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“…There has been limited research on quantifying the number and mass of airborne NPs owing to the existence of a methodological gap for detecting particles ranging in size from 1 nm to 1 μm. , Previous studies have shown that the count of NP particles also increases as particle size decreases, , resulting in up to orders of magnitude greater particle counts as MP degrades to NP. A previous study exhibited that the size distribution of MNPs also followed a power-law distribution with an exponent of −3.019 ( R 2 : 0.98) when combining data on both AMPs and ANPs .…”

Section: Resultsmentioning

confidence: 99%

Probabilistic Estimation of Airborne Micro- and Nanoplastic Intake in Humans

Chen,

Meng,

Liu

et al. 2024

Environ. Sci. Technol.

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Little research exists on the magnitude, variability, and uncertainty of human exposure to airborne micro- and nanoplastics (AMNPs), despite their critical role in human exposure to MNPs. We probabilistically estimate the global intake of AMNPs through three main pathways: indoor inhalation, outdoor inhalation, and ingestion during indoor meals, for both children and adults. The median inhalation of AMPs is 1,207.7 (90% CI, 42.5–8.48 × 104) and 1,354.7 (90% CI, 47.4–9.55 × 104) N/capita/day for children and adults, respectively. The annual intake of AMPs is 13.18 mg/capita/a for children and 19.10 mg/capita/a for adults, which is approximately one-fifth and one-third of the mass of a standard stamp, assuming a consistent daily intake of medians. The majority of AMP number intake occurs through inhalation, while the ingestion of deposited AMPs during meals contributes the most in terms of mass. Furthermore, the median ANP intake through outdoor inhalation is 9,638.1 N/day (8.23 × 10–6 μg/d) and 5,410.6 N/day (4.62 × 10–6 μg/d) for children and adults, respectively, compared to 5.30 × 105 N/day (5.79 × 10–4 μg/d) and 6.00 × 105 N/day (6.55 × 10–4 μg/d) via indoor inhalation. Considering the increased toxicity of smaller MNPs, the significant number of ANPs inhaled warrants great attention. Collaborative efforts are imperative to further elucidate and combat the current MPN risks.

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Section: Resultsmentioning

confidence: 99%

Probabilistic Estimation of Airborne Micro- and Nanoplastic Intake in Humans

Chen,

Meng,

Liu

et al. 2024

Environ. Sci. Technol.

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“…In addition, plastic production workers and inhabitants adjacent to plastic production and waste disposal sites experience increased risk of premature birth, low birth weight, asthma, childhood leukemia, cardiovascular disease, chronic obstructive pulmonary disease, and lung cancer (Landrigan et al, 2023). In addition to chemical toxicity, it has been suggested that also the inert nature of synthetic polymers can trigger oxidative stress and inflammation (Büks et al, 2020;Yoon et al, 2021) as well as carcinogenic responses (Choudhury et al, 2023). The World Health Organization (WHO) considers that MPs <10 µm have the highest implication for human health (WHO, 2022) due to their ability to penetrate into organ tissue (Kadac-Czapska et al, 2023).…”

Section: Microplastic Toxicity In Humansmentioning

confidence: 99%

Majority of potable water microplastics are smaller than the 20 µm EU methodology limit for consumable water quality

Hagelskjær,

Margenat

et al. 2024

Preprint

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Microplastic (MP) content in nutrition including potable water is unregulated, although MP concentrations in bottled water can diverge by several orders of magnitude. The EU Directive 2020/2184 on consumable water quality recently proposed methodological approaches to the detection of MPs in potable water in the size range of 20-5000 µm. However, small MPs in the 1-20 µm range are far more likely to pass the human intestine into blood and organs. We therefore investigated MP concentrations down to 1 µm in ten individual polyethylene terephthalate (PET) bottled water brands and one tap water sample by Raman microspectroscopy. Our analyses are supported by procedural blank- (negative control) and analytical recovery correction (positive control) using red polyethylene fragments in the 5-100 µm range. We find that MP concentrations range from 19 to 1,154 (n/L) [0.001 to 0.250 µg/L]. Importantly, 98 and 94% of MPs measured less than 20 and 10 µm in diameter, respectively, demonstrating the importance of small MP inclusion in potable water analyses and regulation.

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“…However, it is essential to note that the toxicity of ZnO nanoparticles can be mitigated by modifying their physicochemical properties. For example, using larger-sized nanoparticles can reduce their ability to penetrate the respiratory system and interact with the underlying cells [107]. Coating ZnO nanoparticles with biocompatible materials can reduce their toxicity and improve their biocompatibility [33].…”

Section: Pulmonary Toxicitymentioning

confidence: 99%

Emerging Trends in the Application of Green Synthesized Biocompatible ZnO Nanoparticles for Translational Paradigm in Cancer Therapy

Naser,

Ghosh,

Simnani

et al. 2023

JNT

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Zinc oxide nanomaterials have been the cynosure of this decade because of their immense potential in different biomedical applications. It includes their usage in the prognosis and treatment of different infectious and cellular diseases, owing to their peculiar physiochemical properties such as variable shape, size, and surface charge etc. Increasing demand and usage of the ZnO nanomaterials raise concerns about their cellular and molecular toxicity and their biocompatibility with human cells. This review comprehensively details their physiochemical properties for usage in biomedical applications. Furthermore, the toxicological concerns of ZnO nanomaterials with different types of cellular systems have been reviewed. Moreover, the biomedical and biocompatible efficacy of ZnO nanomaterials for cancer specific pathways has been discussed. This review offers insights into the current scenario of ZnO nanomaterials usage and signifies their potential future extension usage on different types of biomedical and environmental applications.

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Atmospheric microplastic and nanoplastic: The toxicological paradigm on the cellular system

Cited by 21 publications

References 242 publications

Probabilistic Estimation of Airborne Micro- and Nanoplastic Intake in Humans

Probabilistic Estimation of Airborne Micro- and Nanoplastic Intake in Humans

Majority of potable water microplastics are smaller than the 20 µm EU methodology limit for consumable water quality

Emerging Trends in the Application of Green Synthesized Biocompatible ZnO Nanoparticles for Translational Paradigm in Cancer Therapy

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