Atmospheric exposure to the major Artemisia pollen allergen (Art v 1): Seasonality, impact of weather, and clinical implications

Grewling, Łukasz; Bogawski, Paweł; Kostecki, Łukasz; Nowak, Małgorzata; Szymańska, Agata; Frątczak, Agata

doi:10.1016/j.scitotenv.2020.136611

Cited by 25 publications

(14 citation statements)

References 74 publications

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“…To calculate the daily potency of airborne Poaceae pollen (allergen release per pollen), the daily value of noted Phl p 5 was divided by the mean daily Poaceae pollen concentration and expressed as pg Phl p 5/pollen ( Celenk, 2019 ; Grewling et al., 2020 ).…”

Section: Methodsmentioning

confidence: 99%

Relationship between Poaceae pollen and Phl p 5 allergen concentrations and the impact of weather variables and air pollutants on their levels in the atmosphere

Ščevková

Vašková

Sepšiová

et al. 2020

Heliyon

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The sensitization to grass pollen is a known problem in European countries. Phl p 5 is an important allergen recognized by the majority of grass sensitized individuals. In this study, we evaluated daily variation in airborne Poaceae pollen and Phl p 5 allergen concentrations to determine whether airborne pollen concentrations alone are sufficient to reflect the actual allergenic potential of the air. The relationships between the mentioned pollen and allergen concentrations and associated environmental variables were also examined. The airborne particles were collected during the Poaceae flowering season in Bratislava in 2019. Pollen sampling was performed using a Hirst-type sampler, while a cyclone sampler was used for the aeroallergen capturing. Allergenic molecules were quantified by ELISA assay. The associations between pollen and allergen concentrations showed that these two variables are positively correlated; however, the correlation was not significant. We observed the concurrent occurrence of airborne pollen and allergen peaks on the same day. Nevertheless, during some days of the pollen season, the allergen concentrations did not correspond to the airborne pollen values. Moreover, the days with low pollen concentration but high pollen potency and vice versa were observed. The effect of selected environmental variables on daily pollen and allergen concentrations was evaluated through Spearman ' s correlation analysis. Of all meteorological variables considered, air temperature, precipitation, and relative air humidity were significantly correlated with airborne pollen and/or allergen concentrations. The association with air temperature was positive, while the negative association was observed with precipitation and relative air humidity. Among the atmospheric pollutants, O 3 and PM 10 were significantly and positively associated with both pollen and allergen concentrations, whereas CO and PM 2.5 were significantly and positively associated only with pollen concentration.

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Section: Methodsmentioning

confidence: 99%

Relationship between Poaceae pollen and Phl p 5 allergen concentrations and the impact of weather variables and air pollutants on their levels in the atmosphere

Ščevková

Vašková

Sepšiová

et al. 2020

Heliyon

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“…Respiratory allergies represent a global health issue, and pollen is considered one of the important risk factors for allergic diseases (Pawankar et al 2013). Artemisia pollen grains are recognized as a relevant source of aeroallergens worldwide, with a distinct allergenicity for the different species of the genus, influenced both by genetic and environmental (e.g., weather and pollution) factors (Grewling et al 2020). In Trentino-Alto Adige (Northern Italy), where the present study was carried out, the aerobiological data for the last 25 years indicate an increase of the Artemisia pollen load in the air, occurring since September (Fig.…”

Section: Discussionmentioning

confidence: 70%

The late flowering of invasive species contributes to the increase of Artemisia allergenic pollen in autumn: an analysis of 25 years of aerobiological data (1995–2019) in Trentino-Alto Adige (Northern Italy)

Cristofori

Bucher²,

Rossi³

et al. 2020

Aerobiologia

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Artemisia pollen is an important aeroallergen in late summer, especially in central and eastern Europe where distinct anemophilous Artemisia spp. produce high amounts of pollen grains. The study aims at: (i) analyzing the temporal pattern of and changes in the Artemisia spp. pollen season; (ii) identifying the Artemisia species responsible for the local airborne pollen load. Daily pollen concentration of Artemisia spp. was analyzed at two sites (BZ and SM) in Trentino-Alto Adige, North Italy, from 1995 to 2019. The analysis of airborne Artemisia pollen concentrations evidences the presence of a bimodal curve, with two peaks, in August and September, respectively. The magnitude of peak concentrations varies across the studied time span for both sites: the maximum concentration at the September peak increases significantly for both the BZ (p < 0.05) and SM (p < 0.001) site. The first peak in the pollen calendar is attributable to native Artemisia species, with A. vulgaris as the most abundant; the second peak is mostly represented by the invasive species A. annua and A. verlotiorum (in constant proportion along the years), which are causing a considerable increase in pollen concentration in the late pollen season in recent years.. The spread of these species can affect human health, increasing the length and severity of allergenic pollen exposure in autumn, as well as plant biodiversity in both natural and cultivated areas, with negative impacts on, e.g., Natura 2000 protected sites and crops.

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“…In different geographic regions, there are different dominant Artemisia species with varying flowering time. Pollen peaks and Art v 1 content levels have been reported as higher during A. campestris flowering than that of A. vulgaris [35 ]. Choosing the most relevant species in specific areas could improve the accuracy and efficiency of diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Variation in IgE binding potencies of seven Artemisia species depending on content of major allergens

Zhao

Gao

et al. 2020

Clin Transl Allergy

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Background Artemisia weed pollen allergy is important in the northern hemisphere. While over 350 species of this genus have been recorded, there has been no full investigation into whether different species may affect the allergen diagnosis and treatment. This study aimed to evaluate the variations in amino acid sequences and the content of major allergens, and how these affect specific IgE binding capacity in representative Artemisia species. Methods Six representative Artemisia species from China and Artemisia vulgaris from Europe were used to determine allergen amino acid sequences by transcriptome, gene sequencing and mass spectrometry of the purified allergen component proteins. Sandwich ELISAs were developed and applied for Art v 1, Art v 2 and Art v 3 allergen quantification in different species. Aqueous pollen extracts and purified allergen components were used to assess IgE binding by ELISA and ImmunoCAP with mugwort allergic patient serum pools and individual sera from five areas in China. Results The Art v 1 and Art v 2 homologous allergen sequences in the seven Artemisia species were highly conserved. Art v 3 type allergens in A. annua and A. sieversiana were more divergent compared to A. argyi and A. vulgaris. The allergen content of Art v 1 group in the seven extracts ranged from 3.4% to 7.1%, that of Art v 2 from 1.0% to 3.6%, and Art v 3 from 0.3% to 10.5%. The highest IgE binding potency for most Chinese Artemisia allergy patients was with A. annua pollen extract, followed by A. vulgaris and A. argyi, with A. sieversiana significantly lower. Natural Art v 1-3 isoallergens from different species have almost equivalent IgE binding capacity in Artemisia allergic patients from China. Conclusion and clinical relevance There was high sequence similarity but different content of the three group allergens from different Artemisia species. Choice of Artemisia annua and A. argyi pollen source for diagnosis and immunotherapy is recommended in China.

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Atmospheric exposure to the major Artemisia pollen allergen (Art v 1): Seasonality, impact of weather, and clinical implications

Cited by 25 publications

References 74 publications

Relationship between Poaceae pollen and Phl p 5 allergen concentrations and the impact of weather variables and air pollutants on their levels in the atmosphere

Relationship between Poaceae pollen and Phl p 5 allergen concentrations and the impact of weather variables and air pollutants on their levels in the atmosphere

The late flowering of invasive species contributes to the increase of Artemisia allergenic pollen in autumn: an analysis of 25 years of aerobiological data (1995–2019) in Trentino-Alto Adige (Northern Italy)

Variation in IgE binding potencies of seven Artemisia species depending on content of major allergens

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