2007
DOI: 10.1038/sj.onc.1210722
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ATM-dependent nuclear accumulation of IKK-α plays an important role in the regulation of p73-mediated apoptosis in response to cisplatin

Abstract: I kappa B kinase (IKK) complex plays an important role in the regulation of signaling pathway that activates nuclear factor-kappa-B (NF-jB). Recently, we reported that cisplatin (CDDP) treatment causes a remarkable nuclear accumulation of IKK-a in association with stabilization and activation of p73. However, underlying mechanisms of CDDP-induced nuclear accumulation of IKK-a are elusive. Here, we found that ataxia-telangiectasia mutated (ATM) is one of upstream mediators of IKK-a during CDDP-induced apoptosis… Show more

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Cited by 48 publications
(45 citation statements)
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“…For example, checkpoint pathways involving ATM, ATR and p38 MAPK are operational on DNA damage and replicational stress (Reinhardt et al, 2007;Grallert and Boye, 2008). Although we could not detect a lack of ATM or CHK1 activation in HU-treated HCT-116 p53À cells, these kinases could regulate p53-dependent NF-kB actions, possibly collateral with RSK1 and MEK1 that govern the nuclear p53/p65 cross talk (Armstrong et al, 1995;Ryan et al, 2000;Bohuslav et al, 2004;Yoshida et al, 2008). Our data and a recent report (Kawauchi et al, 2008a) reveal physical interactions between p65 and p53, which may allow an IkB kinase a-dependent transit of CBP (Huang et al, 2007).…”
Section: Control Of Activated Nf-jb By P53mentioning
confidence: 51%
“…For example, checkpoint pathways involving ATM, ATR and p38 MAPK are operational on DNA damage and replicational stress (Reinhardt et al, 2007;Grallert and Boye, 2008). Although we could not detect a lack of ATM or CHK1 activation in HU-treated HCT-116 p53À cells, these kinases could regulate p53-dependent NF-kB actions, possibly collateral with RSK1 and MEK1 that govern the nuclear p53/p65 cross talk (Armstrong et al, 1995;Ryan et al, 2000;Bohuslav et al, 2004;Yoshida et al, 2008). Our data and a recent report (Kawauchi et al, 2008a) reveal physical interactions between p65 and p53, which may allow an IkB kinase a-dependent transit of CBP (Huang et al, 2007).…”
Section: Control Of Activated Nf-jb By P53mentioning
confidence: 51%
“…It has been reported previously that HuR function is regulated by a series of DNA damage response kinases (33). As IKK␣ is also involved in mediating DNA damage response downstream of ataxia-telangiectasia mutated (34), this finding adds IKK␣ to the list of DNA damage response kinases involved in HuR regulation.…”
Section: Discussionmentioning
confidence: 66%
“…This process is critical for CDDP-induced apoptosis. [35][36][37][38] Moreover, IKK␣ inhibits squamous cell carcinogenesis by acting as a major cofactor in a transforming growth factor ␤-Smad2/3 signaling pathway that is Smad4 independent. 37,38 Unlike IKK␣, IKK is amplified/overexpressed in a number of breast cancers, and functions as an oncogene.…”
Section: Discussionmentioning
confidence: 99%