Atlastin-1 regulates endosomal tubulation and lysosomal proteolysis in human cortical neurons
Eliska Zlamalova,
Catherine Rodger,
Francesca Greco
et al.
Abstract:Mutation of theATL1gene is one of the most common causes of hereditary spastic paraplegia (HSP), a group of genetic neurodegenerative conditions characterised by distal axonal degeneration of the corticospinal tract axons. Atlastin-1, the protein encoded byATL1, is one of three mammalian atlastins, which are homologous dynamin-like GTPases that control endoplasmic reticulum (ER) morphology by fusing tubules to form the three-way junctions that characterise ER networks. However, it is not clear whether atlastin… Show more
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