Atlas of Genetics and Cytogenetics in Oncology and Haematology in 2013

Abstract

The Atlas of Genetics and Cytogenetics in Oncology and Haematology (http://AtlasGeneticsOncology.org) is a peer-reviewed internet journal/encyclopaedia/database focused on genes implicated in cancer, cytogenetics and clinical entities in cancer and cancer-prone hereditary diseases. The main goal of the Atlas is to provide review articles that describe complementary topics, namely, genes, genetic abnormalities, histopathology, clinical diagnoses and a large iconography. This description, which was historically based on karyotypic abnormalities and in situ hybridization (fluorescence in situ hybridization) techniques, now benefits from comparative genomic hybridization and massive sequencing, uncovering a tremendous amount of genetic rearrangements. As the Atlas combines different types of information (genes, genetic abnormalities, histopathology, clinical diagnoses and external links), its content is currently unique. The Atlas is a cognitive tool for fundamental and clinical research and has developed into an encyclopaedic work. In clinical practice, it contributes to the cytogenetic diagnosis and may guide treatment decision making, particularly regarding rare diseases (because they are numerous and are frequently encountered). Readers as well as the authors of the Atlas are researchers and/or clinicians.

Cytogenetic and Molecular Findings in Children with Acute Lymphoblastic Leukemia: Experience of a Single Institution in Argentina

“…All of them are associated with different types of cancers. It is remarkable to have found the ABL2 gene in 1q25, which is a proto-oncogene whose protein is a non-receptor tyrosine kinase, and the TPR gene in the same region; its extreme 5 ′ end fuses with several different kinase genes in some neoplasias and could be involved in leukemogenesis mechanisms [Huret et al, 2013]. Moreover, ABL2 has been associated with the Ph-like subgroup of ALL, which is a targetable kinase-activating lesion [Roberts et al, 2014].…”

Carrageenan Inhibits Insulin Signaling through GRB10-mediated Decrease in Tyr(P)-IRS1 and through Inflammation-induced Increase in Ser(P)307-IRS1

“…GRB10 is an adaptor protein with pleckstrin homology and Src homology 2 domains and binds with receptor tyrosine kinases, including the insulin receptor (9,10). GRB10 acts as a negative regulator of signaling from the insulin receptor (11)(12)(13)(14)(15)(16).…”

Assessment of Ionizing Radiation Induced Dicentric Chromosome and Micronuclei in Human Peripheral Blood Lymphocytes for Preliminary Reconstruction of Cytogenetic Biodosimetry

“…There are factors that influence the observed frequencies of MN and also known to have an impact on the resulting calibration curves, such as differences in the lymphocyte donors and culture protocols, slide preparation, and scoring criteria [25,34]. Therefore, to increase the accuracy of dose estimation, each laboratory should have its own calibration curve.…”