Atlas of Functional Neuroanatomy

Khonsary, Seyed Ali

doi:10.25259/sni_424_2022

Cited by 1 publication

(1 citation statement)

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“…Abnormal diffusion (lower fractional anisotropy) was reported in the SCP for multiple sclerosis patients with cerebellar symptoms and this correlated with cognitive performance (Nicoletti et al, 2017). The SCP has large sensory and motor nerve tracts that connect the cortex and pons and facilitate refined motor movements, learning of new motor skills, and balance (Khonsary, 2022). However, the function of this region needs to be investigated in different diseases.…”

Section: Long Covid Vs Hc Group Comparisonmentioning

confidence: 99%

Brainstem volume changes in myalgic encephalomyelitis/chronic fatigue syndrome and long COVID patients

et al. 2023

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Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID patients have overlapping neurological, autonomic, pain, and post-exertional symptoms. We compared volumes of brainstem regions for 10 ME/CFS (CCC or ICC criteria), 8 long COVID (WHO Delphi consensus), and 10 healthy control (HC) subjects on 3D, T1-weighted MRI images acquired using sub-millimeter isotropic resolution using an ultra-high field strength of 7 Tesla. Group comparisons with HC detected significantly larger volumes in ME/CFS for pons (p = 0.004) and whole brainstem (p = 0.01), and in long COVID for pons (p = 0.003), superior cerebellar peduncle (p = 0.009), and whole brainstem (p = 0.005). No significant differences were found between ME/CFS and long COVID volumes. In ME/CFS, we detected positive correlations between the pons and whole brainstem volumes with “pain” and negative correlations between the midbrain and whole brainstem volumes with “breathing difficulty.” In long COVID patients a strong negative relationship was detected between midbrain volume and “breathing difficulty.” Our study demonstrated an abnormal brainstem volume in both ME/CFS and long COVID consistent with the overlapping symptoms.

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Section: Long Covid Vs Hc Group Comparisonmentioning

confidence: 99%