Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis

Sato, Shogo; Dyar, Kenneth A.; Treebak, Jonas T.; Jepsen, Sara L.; Ehrlich, A; Ashcroft, Stephen P.; Trošt, Kajetan; Kunzke, Thomas; Prade, Verena M.; Small, Lewin; Basse, Astrid L.; Schönke, Milena; Chen, Siwei; Samad, Muntaha; Baldi, Pierre; Barrès, Romain; Walch, Axel; Moritz, Thomas; Holst, Jens J.; Lutter, Dominik; Zierath, Juleen R.; Sassone–Corsi, Paolo

doi:10.1016/j.cmet.2021.12.016

Cited by 95 publications

(91 citation statements)

References 61 publications

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“…To gain further insight on the inter-relationship between Trp metabolism, circadian rhythms and environmental cues, we revisited our metabolomics datasets of high-fat diet-induced obesity [ 22 ] and physical exercise [ 51 ], both of which rewired circadian metabolic homeostasis. High-fat diet feeding altered the levels and rhythms of Trp metabolites in the liver, serum and SCN ( Figures S1A–C ).…”

Section: Resultsmentioning

confidence: 99%

Tryptophan metabolism is a physiological integrator regulating circadian rhythms

Petrus

Cervantes²,

Samad³

et al. 2022

Molecular Metabolism

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Section: Resultsmentioning

confidence: 99%

Tryptophan metabolism is a physiological integrator regulating circadian rhythms

Petrus

Cervantes²,

Samad³

et al. 2022

Molecular Metabolism

Self Cite

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“…After exercise, corticosterone was the only metabolite that was consistently higher in both male and female hearts. While not measured in this study, blood levels of corticosterone have been shown to increase immediately after exercise in several species, 58 , 59 , 60 , 61 , 62 , 63 , 64 which could underlie its higher abundance in the heart after exercise. Corticosterone is required in fetal cardiac development, 65 and corticosterone signaling is essential for maintaining cardiac function in adult mice.…”

Section: Discussionmentioning

confidence: 65%

Influence of biological sex and exercise on murine cardiac metabolism

Fulghum

Collins

Jones

et al. 2022

Journal of Sport and Health Science

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“…Altogether, these interconnected elements drive and ensure the robustness of 24 h rhythmic oscillations in the expression of various additional target genes also known as clock-controlled genes (CCGs) ( Figure 2B ). CCGs are involved in various cellular mechanisms, including metabolism ( Eckel-Mahan and Sassone-Corsi, 2013 ; Fuhr et al, 2018 ; Reinke and Asher, 2019 ; Sato et al, 2022 ), RNA processing ( El-Athman et al, 2018 ; Yeung et al, 2018 ; El-Athman et al, 2019 ), cell cycle ( Shostak et al, 2016 ; El-Athman et al, 2017 ; Farshadi et al, 2020 ), DNA damage response ( Ando et al, 2001 ; Sancar et al, 2010 ; Preußner et al, 2017 ), and apoptosis ( Lee and Sancar, 2011 ), which are often dysregulated in the context of pathological development. The circadian clock has also been reported to directly modulate the cell cycle via regulation of checkpoints such as Myc ( Altman et al, 2015 ; Shostak et al, 2016 ), Wee1 ( Matsuo et al, 2003 ), p21 ( Gréchez-Cassiau et al, 2008 ), and p16 ( Kowalska et al, 2013 ; El-Athman et al, 2017 ).…”

Section: Making Biological Time: the Molecular And Neural Circuits Me...mentioning

confidence: 99%

It’s About Time: The Circadian Network as Time-Keeper for Cognitive Functioning, Locomotor Activity and Mental Health

et al. 2022

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A variety of organisms including mammals have evolved a 24h, self-sustained timekeeping machinery known as the circadian clock (biological clock), which enables to anticipate, respond, and adapt to environmental influences such as the daily light and dark cycles. Proper functioning of the clock plays a pivotal role in the temporal regulation of a wide range of cellular, physiological, and behavioural processes. The disruption of circadian rhythms was found to be associated with the onset and progression of several pathologies including sleep and mental disorders, cancer, and neurodegeneration. Thus, the role of the circadian clock in health and disease, and its clinical applications, have gained increasing attention, but the exact mechanisms underlying temporal regulation require further work and the integration of evidence from different research fields. In this review, we address the current knowledge regarding the functioning of molecular circuits as generators of circadian rhythms and the essential role of circadian synchrony in a healthy organism. In particular, we discuss the role of circadian regulation in the context of behaviour and cognitive functioning, delineating how the loss of this tight interplay is linked to pathological development with a focus on mental disorders and neurodegeneration. We further describe emerging new aspects on the link between the circadian clock and physical exercise-induced cognitive functioning, and its current usage as circadian activator with a positive impact in delaying the progression of certain pathologies including neurodegeneration and brain-related disorders. Finally, we discuss recent epidemiological evidence pointing to an important role of the circadian clock in mental health.

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Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis

Cited by 95 publications

References 61 publications

Tryptophan metabolism is a physiological integrator regulating circadian rhythms

Tryptophan metabolism is a physiological integrator regulating circadian rhythms

Influence of biological sex and exercise on murine cardiac metabolism

It’s About Time: The Circadian Network as Time-Keeper for Cognitive Functioning, Locomotor Activity and Mental Health

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