Atlas of Circadian Metabolism Reveals System-wide Coordination and Communication between Clocks

Dyar, Kenneth A.; Lutter, Dominik; Artati, Anna; Ceglia, Nicholas; Liu, Yu; Armenta, Danny; Jastroch, Martin; Schneider, Sandra; Mateo, Sara de; Cervantes, Marlene; Abbondante, Serena; Tognini, Paola; Orozco-Solís, Ricardo; Kinouchi, Kenichiro; Wang, Christina; Swerdloff, Ronald S.; Nadeef, Seba; Masri, Selma; Magistretti, Pierre J.; Orlando, Valerio; Borrelli, Emiliana; Uhlenhaut, N. Henriette; Baldi, Pierre; Adamski, Jerzy; Tschöp, Matthias H.; Eckel‐Mahan, Kristin; Sassone–Corsi, Paolo

doi:10.1016/j.cell.2018.08.042

Cited by 265 publications

(244 citation statements)

References 97 publications

(122 reference statements)

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“…Thus, we have data from 13 separate trials (mean ± sd, 57.6 + 7.24 years, range 38–69 yrs; 5 female, all post-menopausal). There is evidence that high-fat diet disrupts circadian rhythms and exacerbates the adverse effects of circadian disruption on metabolism [22, 45]. To study the interaction between circadian disruption and macronutrient composition on metabolism, we gave a subset of participants in each experimental condition a high-fat diet during the study (RCD group n=3, Control group n=2).…”

Section: Star Methodsmentioning

confidence: 99%

Human Resting Energy Expenditure Varies with Circadian Phase

et al. 2018

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SUMMARY There is emerging evidence that circadian misalignment may alter energy expenditure, leading to obesity risk among those with irregular schedules[1–5]. It has been reported that energy expenditure is affected by the timing of sleep, exercise, and meals[6]. However, it is unclear whether the circadian system also modulates energy expenditure, independent of behavioral state and food intake. Here, we used a forced desynchrony protocol to examine whether fasted resting energy expenditure (REE) varies with circadian phase in 7 participants. This protocol allowed us to uncouple sleep-wake and activity-related effects from the endogenous circadian rhythm, demonstrating that REE varies by circadian phase. REE is lowest at circadian phase ~0°, corresponding to the endogenous core body temperature (CBT) nadir in the late biological night, and highest at circadian phase ~180° in the biological afternoon/evening. Furthermore, we found that respiratory quotient (RQ), reflecting macronutrient utilization, also varies by circadian phase. RQ is lowest at circadian phase ~240° and highest at circadian phase ~60°, which corresponds to biological morning. This is the first characterization of a circadian profile in fasted resting energy expenditure and fasted respiratory quotient (with rhythmic profiles in both carbohydrate and lipid oxidation), decoupled from effects of activity, sleep-wake cycle, and diet in humans. The rhythm in energy expenditure and macronutrient metabolism may contribute to greater weight gain in shift workers and others with irregular schedules.

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Section: Star Methodsmentioning

confidence: 99%

Human Resting Energy Expenditure Varies with Circadian Phase

et al. 2018

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“…Many of the pathways and genes identified in the control of whole-body and cellular glucose and energy homeostasis are under circadian control (Eckel-Mahan & Sassone-Corsi, 2013). Furthermore, many of these circadian controlled genes have been described as being altered in response to exercise (Schroder & Esser, 2013) or nutrient stress (high-fat diet) (Dyar et al 2018). In mice, gene expression and metabolic adaptations to exercise vary according to zeitgeber time (Peek et al 2017).…”

Section: Interaction Between Circadian Rhythms and The Metabolic Respmentioning

confidence: 99%

“…The interaction between zeitgeber time and the metabolic response of the adipocyte is likely to be influenced by exercise, given the recent paradigm underscoring how intra-and inter-tissue relationships coordinate the organismal response to nutrient stressors (Dyar et al 2018). Therefore, the field is ripe to address several questions related to exercise and nutrient timing.…”

Section: Interaction Between Circadian Rhythms and The Metabolic Respmentioning

confidence: 99%

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Interplay between diet, exercise and the molecular circadian clock in orchestrating metabolic adaptations of adipose tissue

Dollet

Zierath

2019

The Journal of Physiology

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Disruption of circadian rhythmicity induced by prolonged light exposure, altered sleep patterns and shift work is associated with the development of obesity and related metabolic disorders, including type 2 diabetes and cardiovascular diseases. White and brown adipose tissue activity shows circadian rhythmicity, with daily variations in the regulation of metabolic processes such as lipolysis, glucose and lipid uptake, and adipokine secretion. The role of the circadian clock in the regulation of energy homeostasis has raised interest in clock‐related strategies to mitigate metabolic disturbances associated with type 2 diabetes, including ‘resynchronizing’ metabolism through diet or targeting a particular time of a day to potentiate the effect of a pharmacological or physiological treatment. Exercise is an effective intervention to prevent insulin resistance and type 2 diabetes. Beyond its effect on skeletal muscle, exercise training also has a profound effect on adipose tissue. Adipose tissue partly mediates the beneficial effect of exercise on glucose and energy homeostasis, via its metabolic and endocrine function. The interaction between zeitgeber time and diet or exercise is likely to influence the metabolic response of adipose tissue and therefore impact the whole‐body phenotype. Understanding the impact of circadian clock systems on human physiology and how this is regulated by exercise in a tissue‐specific manner will yield new insights for the management of metabolic disorders.

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“…122 Liver-specific Bmal1KO leads to reduced lipid accumulation in hepatic cells via increased mRNA methylation, in particular of PPARα. 136 123 This finding further emphasizes that m6A RNA methylation plays an important regulatory role for the circadian modulation of metabolic outputs, via alteration of gene transcription and lipid metabolism.…”

Section: Of Mammalian Physiology and Metabolismmentioning

confidence: 68%

The importance of being rhythmic: Living in harmony with your body clocks

Dibner

2019

Acta Physiologica

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OSCILLATORSThe time-keeping system, dubbed "circadian" from Latin circa diem (about a day), allows light-sensitive beings, including humans, to coordinate their physiology and behaviour to the daily changes in geophysical time (Figure 1). The mammalian network of body clocks is organized in a strictly hierarchical manner. A master oscillator, residing in the paired suprachiasmatic nuclei (SCN) of the hypothalamus ( Figure 1A), synchronizes a myriad of peripheral oscillators situated in each organ ( Figure 1B) on a daily basis. In turn, rhythmicity in the SCN is entrained by external timecues or Zeitgebers (German term for time givers). Daily changes in light intensity, detected by classical photoreceptors and intrinsically light-sensitive retinal ganglion cells expressing AbstractCircadian rhythms have developed in all light-sensitive organisms, including humans, as a fundamental anticipatory mechanism that enables proactive adaptation to environmental changes. The circadian system is organized in a highly hierarchical manner, with clocks operative in most cells of the body ensuring the temporal coordination of physiological processes. Circadian misalignment, stemming from modern life style, draws increasing attention due to its tight association with the development of metabolic, cardiovascular, inflammatory and mental diseases as well as cancer.This review highlights recent findings emphasizing the role of the circadian system in the temporal orchestration of physiology, with a particular focus on implications of circadian misalignment in human pathologies. K E Y W O R D Scircadian clock, circadian misalignment, continuous recording of circadian bioluminescence, human physiology How to cite this article: Dibner C. The importance of being rhythmic: Living in harmony with your body clocks. Acta Physiol. 2020;228:e13281. https ://doi.

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Atlas of Circadian Metabolism Reveals System-wide Coordination and Communication between Clocks

Cited by 265 publications

References 97 publications

Human Resting Energy Expenditure Varies with Circadian Phase

Human Resting Energy Expenditure Varies with Circadian Phase

Interplay between diet, exercise and the molecular circadian clock in orchestrating metabolic adaptations of adipose tissue

The importance of being rhythmic: Living in harmony with your body clocks

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