Atlas for Stereotaxic Brain Research on the Conscious Rabbit

Monnier, M; Gangloff, H.

doi:10.1097/00000441-196112000-00018

Cited by 162 publications

(73 citation statements)

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“…At the start of each experiment a stainless steel cannula attached to a syringe by about 20 cm, 00 nylon tubing and filled with artificial cerebro-spinal fluid (C.S.F.) (Cameron & Semple, 1968) was inserted into one lateral cerebral ventricle using the co-ordinates of Monnier & Gangloff (1961). In all the experiments fever was produced as described above by an intravenous priming injection followed by a sustaining infusion of homologous rabbit EP.…”

Section: Methodsmentioning

confidence: 99%

Influence of the duration of experimental fever on salicylate antipyresis in the rabbit

Cranston¹,

Luff²,

Rawlins³

et al. 1971

British J Pharmacology

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Summary1. Steady state fever has been produced in rabbits with a priming injection followed by a sustaining infusion of homologous plasma containing endogenous pyrogen (EP). This fever appears to last as long as the infusion continues. 2. Intravenous salicylate given 1 h after the start of the EP infusion produced only a small antipyretic effect. The same dose of salicylate given 4 h after the start of an EP infusion resulted in rapid and progressive defervescence. Intermediate antipyretic responses were obtained when salicylate was administered intravenously 2 and 3 h after the start of an EP infusion.3. Less than 1 % of the systemic dose, when injected into a lateral cerebral ventricle, produced a significantly smaller response at 1 h than at 4 h after the start of an EP infusion. At both these times the fall in temperature following the intraventricular salicylate injection was dose dependent, but the slope of the dose-response line was significantly steeper at 4 h than at 1 hour. 4. It is suggested that salicylates produce their antipyretic effects by antagonizing the action of EP within the nervous system, and that the hypothalamic EP concentration falls during the course of an EP infusion.

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Section: Methodsmentioning

confidence: 99%

Influence of the duration of experimental fever on salicylate antipyresis in the rabbit

Cranston¹,

Luff²,

Rawlins³

et al. 1971

British J Pharmacology

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“…One end of the canulae was left open for breathing and the other end was connected with a 500 ml water reservoir with a dripping infusion apparatus, through which the fresh water or sea water was infused into the trachea at a rate of 0.5 to 2.0 ml per min. Implantation of permanent electrodes was done by the method reported previously (Komura et al 1973), according to the atlas of Sawyer et al (1954) and Monnier and Gangloff (1961). The position of cortical and subcortical electrodes was as follows: Cortex sensitivo-motorius (Cm) at anterior (A) 4, lateral (L) 3; Cortex opticus (Co) at posterior (P) 10, L 9; Cortex sensitivus (Cse), P 3, L 9; Amygdala (Amg), A 3, L 6.5, Height (H), 17.5; Nucl.…”

Section: Methodsmentioning

confidence: 99%

Electrophysiological Studies on Slowly Induced Sea and Fresh Water Drowning in Rabbits

Fujimura

Kômura

Furuno

et al. 1979

Tohoku J. Exp. Med.

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-255 -Surface and deep electroencephalograms , electrocardiogram and behavior of 10 male rabbits were studied by infusing fresh water or sea water slowly at a speed of 0.5-2.0 ml/min, by means of a dripping apparatus, into the canulated trachea until the death of the animals.From the behavior of the animal and EEG and ECG findings, the course was divided into 4 stages. The 1st, alert stage; 2nd, adapted or calm stage; 3rd, dyspnea stage; and 4th, covering from the agonal spasm to ECG silence. The course of this drowning death was quite different from that due to a large amount of water aspirated within a short period. The volume of fresh water needed to kill the animals was 7 times larger than that of the sea water in this method, and the latter was less than half of the volume of sea water necessary for the death due to short period aspira tion. The mechanism of death seems to be slow and prolonged asphyxia and, among the terminal events in fresh water drowning, there might occur marked pulmonary hypertension that results in a high degree of lung edema.In the ECG at terminal stage, final bradycardia (84.4% of normal pulse rate) at around the time of surface EEG disappearance, and final tachycardia (142.7% of normal pulse rate) about 120 sec later than final bradycardia and 40 min later than deep EEG disappearance were observed consistently. After clinical signs of death ECG still continued to beat slowly for 1-2 hr.slowly induced sea and fresh water drowning; permanent electrode; EEG; ECG Since the first heart transplantation was performed in 1967 in our country, the donor-problem has been widely discussed all over Japan, not only from the medical but also from the ethical and moral aspects. One of the authors, as a surgeon, has experienced an operative death case in which continuous ECG tracing was taken for more than one hr after the clinical signs of death. But the courses of events around the time of death of living creatures were not clearly documented so as to be readily applied for the resuscitation and/or organ transplantation etc. by any physicians or surgeons.

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“…Various shades of colours are described by the nomenclature used by Loveland (1970), so that Green fluorescence corresponds to a wavelength of 513, and Yellow to 577, whilst in between Green-Yellow is 560, yellowish Green is 545 and greenish Yellow 570nm. Identification of the areas was achieved by toluidine blue staining of the adjacent sections with the help of the stereotaxic atlas of the brain of the rabbit (Monnier & Gangloff, 1961).…”

Section: Methodsmentioning

confidence: 99%

Uptake of 5‐hydroxytryptamine in Different Parts of the Brain of the Rabbit After Intraventricular Injection

Dow

László

1976

British J Pharmacology

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The uptake of 5‐hydroxytryptamine (5‐HT) was investigated in different areas of the rabbit brain (anterior hypothalamus, the raphe, the region of the substantia nigra, several cortical areas and the medulla oblongata) after intraventricular injection in pargyline pretreated animals by the formaldehyde‐induced histochemical fluorescence method. The distribution of fluorescence showed that the uptake of 5‐HT, after circulation in the cerebrospinal fluid, caused a general increase in intensity of green yellow to yellow background fluorescence. There was an increased fluorescence in the nerve terminals, but no uptake occurred either in the cell bodies of neurones or in the glial cells.

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Atlas for Stereotaxic Brain Research on the Conscious Rabbit

Cited by 162 publications

References 0 publications

Influence of the duration of experimental fever on salicylate antipyresis in the rabbit

Influence of the duration of experimental fever on salicylate antipyresis in the rabbit

Electrophysiological Studies on Slowly Induced Sea and Fresh Water Drowning in Rabbits

Uptake of 5‐hydroxytryptamine in Different Parts of the Brain of the Rabbit After Intraventricular Injection

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