Atividade tóxica in vitro de Croton heliotropiifolius Kunth (Euphorbiaceae)

Abstract

Frequentemente encontrado na caatinga, brejo, restinga e cerrado brasileiro, o velame, Croton heliotropiifolius Kunth é popularmente conhecido por suas propriedades medicinais utilizada na dor de estômago, mal estar gástrico, vômitos, diarréia com sangue e para baixar a febre. Além das propriedades farmacológicas, seu óleo essencial apresenta atividade larvicida contra Aedes aegypti, assim como o extrato etanólico apresentou atividade inseticida considerável contra Sitophilus zeamais. O presente trabalho teve como objetivo avaliar a toxicidade preliminar do extrato metanólico de folhas de Croton heliotropiifolius Kunth frente à Artemia salina. O bioensaio foi realizado nas concentrações de 50 µg/ml, 100 µg/ml, 250 µg/ml, 500 µg/ml, 750 µg/ml, 1000 µg/ml de extrato metanólico de folhas. O extrato em estudo apresentou uma moderada toxicidade para a Artemia salina, apresentando valores de CL 50 na faixa de 637,29 µg/mL.

Characterisation of Staphylococcus aureus strains from milk and goat cheese and evaluation of their inhibition by gallic acid, nisin and velame of the Brazilian caatinga

“…Croton heliotropiifolius has medicinal properties. Velame is widely used by local communities in Brazil, especially for the treatment of gastrointestinal disorders and general infections involving fever (Brito et al ; Silva et al ). Consistent with our results, Araújo et al () reported the antimicrobial activity of C. heliotropiifolius against S. aureus and stated that EO has potential applications against multidrug‐resistant strains of Staphylococcus spp.…”

Toxicological potential of ethanol extract of stem bark and Croton heliotropiifolius (Euphorbiaceae)

“…The toxicity of several secondary metabolites, present in vegetal have been described (Silva et al, 2012). The methanol extract of C. heliotropiifolius showed moderate toxicity to the micro crustacean Artemia salina (Silva et al, 2018). After the end of the toxicological assays, it was verified that the EECroton showed to have some action on the central nervous system and peripheral action in the preestablished doses.…”

“…The essential oil has been described as larvicidal against Aedes aegypti (Doria et al, 2010). The methanolic extract of C. heliotropiifolius showed moderate toxicity against the microcrustacean Artemia salina and a low to medium percentage of cell growth inhibition on tumor lines tested (Silva et al, 2018(Silva et al, , 2017. The Human Toxicity Potential (HTP) is an important test to be performed early in the study of medicinal herb.…”