Atividade do extrato hidroetanólico das folhas de Raphanus Sativus em glândulas submandibulares de ratos com diabetes mellitus

Abstract

Diabetes mellitus (DM) is a disease identified by the high level of glucose in the blood that results from a defect in insulin secretion. Individuals with uncontrolled diabetes have important changes in the oral cavity, such as periodontitis and hyposalivation, making them more predisposed to cavities, dry mouth, in addition to affecting immunity and increasing susceptibility to infections. In this study, the activity of the hydroethanolic extract of Raphanus sativus (radish) was evaluated in reducing glycemia and oxidative stress in male wistar rats induced by diabetes using Alloxane (120 mg / kg) and treated over a 90-day period with Raphanus Sativus extract daily by gavage at a concentration of 300 mg / kg / day. The tested extract showed positive results, acting in the reduction of glycemia and oxidative stress, reducing lipoperoxidation (MDA) and protein oxidation in the submandibular glands of rats with diabetes. The hydroethanolic extract of Raphanus sativus has normoglycemic properties and the antioxidant effects were able to reverse the cellular damage caused by oxidative stress. The results of this work show that the extract of Raphanus sativus can become a therapeutic option for the control of glycemia and for the treatment of DM damage involving the oral cavity.