Ativação plaquetária nas formas distintas da doença arterial coronariana

Armaganijan, Dikran

doi:10.1590/s0066-782x2006001700001

Cited by 2 publications

(3 citation statements)

References 9 publications

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“…Thus, TXA2 is coresponsible, together with ADP, for the posterior growth of the hemostatic plug. 36 The observed inhibitory effect can be explained if it is found that coffee is able to inhibit platelets, because if this occurs, the factors necessary for the production of TXA2 or its inactive form, TXB2, will not be released from the platelets. Regarding the studies that verify the lack of effect of coffee on thromboxanes, they may present a bad classification bias and it should be noted that the same occurred in the years 1985 and 1989, being, therefore, older in relation to the study that observes the inhibition of the formation of this regulator.…”

Section: Coffee and Prostanoidsmentioning

confidence: 99%

“…35 Prostanoids are eicosoids, a group to which prostacyclins, prostaglandins, and thromboxanes belong. Among these, prostacyclins, 36 prostaglandin I2 (PGI2), 37 and cyclic 3'5'-adenosine monophosphate (cyclic AMP or cAMP) are regulators that have antiplatelet action. On the other hand, thromboxane A2 (TXA2) and thromboxane B2 (TXB2) have aggregating action, 36 as well as the inhibitor of plasminogen activator type 1 (PAI-1) that can promote the permanence of the fibrin clot inhibiting fibrinolysis.…”

Section: Introductionmentioning

confidence: 99%

“…Among these, prostacyclins, 36 prostaglandin I2 (PGI2), 37 and cyclic 3'5'-adenosine monophosphate (cyclic AMP or cAMP) are regulators that have antiplatelet action. On the other hand, thromboxane A2 (TXA2) and thromboxane B2 (TXB2) have aggregating action, 36 as well as the inhibitor of plasminogen activator type 1 (PAI-1) that can promote the permanence of the fibrin clot inhibiting fibrinolysis. 38 Methylxanthines, such as caffeine, are non-selective blockers of the adenosine receptor 33 and act especially on the A2A receptor, specifically expressed in platelets.…”

Section: Introductionmentioning

confidence: 99%

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Systematic Review of the Effects of Coffee or Its Components on Platelets and Their Regulators

Gache

Vaz

Almeida-de-Souza

2021

Journal of Caffeine and Adenosine Research

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Background: Coffee includes some potentially bioactive components that can interfere with platelets, which can influence coagulation, despite generating controversy. The aim of this systematic review is to verify whether coffee or its components can influence platelet regulators and/or aggregation. Materials and Methods: The research was conducted on July 29, 2021, in PubMed, Scopus, and Web of Science, using the following mesh-terms: (caffeine)) OR (coffee)) AND (platelets). Eligibility criteria were: studies carried out in humans, referring to the effects of coffee consumption, or one of its components, on platelets or their regulators. We exclude in vitro or animal studies, reviews, editorials, and non-English written studies. From a total of 836 publications, 17 articles were included from which we extracted the relationship between coffee consumption and changes in blood platelets and performed a subjective assessment of bias. Results: Ten articles refer to the non-interference of coffee or its components with platelets, nine affirm results that support the increase in platelet aggregation, and eight articles observe the decrease in platelet aggregation when coffee is consumed. Some articles presented the lack of data regarding the sample collection location, age group, or classification as to the type of study, which is limiting. Conclusions: The heterogeneity of results makes it difficult to correctly interpret the possible interaction of coffee or its components with platelets or their regulators. For better interpretation, further studies on this topic should be carried out considering the individualization of coffee components, different platelet regulators, and the size of the sample used.

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Section: Coffee and Prostanoidsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Systematic Review of the Effects of Coffee or Its Components on Platelets and Their Regulators

Gache

Vaz

Almeida-de-Souza

2021

Journal of Caffeine and Adenosine Research

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Volume plaquetário médio e doença cardiovascular

Wendland

Farias

Manfroi³

2009

J. Bras. Patol. Med. Lab.

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As plaquetas têm importante papel no desenvolvimento do trombo intravascular, a maior causa de síndrome coronariana aguda (SCA). Após a erosão ou ruptura da placa aterosclerótica, a ativação das plaquetas é crucial nos eventos pró-trombóticos que levam ao infarto do miocárdio (IM). O aumento da reatividade plaquetária está associado à evolução do volume plaquetário. Plaquetas grandes são enzimática e metabolicamente mais ativas e apresentam alto potencial trombótico. O volume plaquetário médio (VPM) é um marcador da função plaquetária. Níveis elevados de VPM têm sido identificados como fatores de risco independentes para o IM em pacientes com doença cardíaca coronariana. No entanto, os valores biológico e prognóstico de níveis elevados de VPM ainda são controversos. Os novos analisadores hematológicos fornecem esse índice plaquetário como parte integrante do hemograma, não havendo custos adicionais para o laboratório, podendo ser utilizado como marcador precoce de risco de eventos cardiovasculares, associado a marcadores tradicionais. Neste estudo descrevemos o valor clínico do VPM na aterosclerose coronariana e seu papel como fator de risco para SCA.

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Ativação plaquetária nas formas distintas da doença arterial coronariana

Cited by 2 publications

References 9 publications

Systematic Review of the Effects of Coffee or Its Components on Platelets and Their Regulators

Systematic Review of the Effects of Coffee or Its Components on Platelets and Their Regulators

Volume plaquetário médio e doença cardiovascular

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