“…To elucidate the underlying mechanisms by which TRPM7 and O -GlcNAcylation mediate cell motility, we monitored the levels of various proteins known to be important in metastasis of lung tumour, including matrix metalloproteinases MMP-2 and MMP-9, 33 , 34 SOX9, 35 c-Myc and Cav-1, 36 , 37 following TRPM7 inhibition. The results show that MMP-2, MMP-9 and SOX9 were relatively unchanged when comparing TRPM7i and control cells, suggesting their unlikely involvement in the TRPM7/ O -GlcNAc regulatory axis (Fig.…”