Athymic rat model for studying acellular human allograft

Keating, Timothy C.; Isaacs, Jonathan; Mallu, Satya; Baxi, Mihir

doi:10.1016/j.jneumeth.2015.04.012

Cited by 2 publications

(2 citation statements)

References 33 publications

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“…To date, however, an adequate animal model has not been developed. 10 Analysis of available clinical outcomes included in the multicenter active database (the RANGER Registry) offers the best available information to guide future application of acellular nerve allograft. Although not statistically scrutinized, the rates of meaningful motor (85%) and sensory (67%) recovery associated with 4-to 5-mm-diameter allograft repairs appear, at least from a preliminary standpoint, comparable with the use of PNA across all sizes.…”

Section: Discussionmentioning

confidence: 99%

A Preliminary Assessment of the Utility of Large-Caliber Processed Nerve Allografts for the Repair of Upper Extremity Nerve Injuries

Isaacs

Safa²

2016

Hand (New York, N,Y.)

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Background: Cabled sensory nerve autografts are the historical gold standard for overcoming gaps in larger diameter nerves as repair utilizing large-diameter autograft risks central graft necrosis. Commercially available processed nerve allograft (PNA) is available in diameters up to 5 mm but represents an acellular 3-dimensional matrix as opposed to viable tissue. The purpose of this study is to specifically evaluate whether similar concerns regarding the use of large-caliber PNA are warranted. Methods: The RANGER Registry is an active database designed to collect injury, repair, safety, and outcomes data for PNAs (Avance® Nerve Graft; AxoGen, Inc, Alachua, Florida) according to an institutional review board-approved protocol. The database was queried for patients presenting with large-caliber nerve allograft repairs in the upper extremity. Identified patients reporting quantitative outcomes with a minimum of 9-month follow-up were included in the data set. Results: The large-caliber PNA subgroup included 13 patients with 15 injuries. The mean ± SD age was 36 ± 22 years. Large-caliber single-stranded repairs included twelve 4-to 5-mm-diameter grafts. Large-caliber cabled repairs included the combined use of 3-to 4-mm and 4-to 5-mm-diameter nerve allografts in 3 repairs. The mean nerve gap was 33 ± 10 mm with a mean follow-up time of 13 months. Available quantitative data reported meaningful recovery of sensory and motor function in 67% and 85% of the repairs, respectively. Conclusion: Although based on a small subset of patients, PNAs of up to 5 mm in diameter appear capable of supporting successful nerve regeneration.

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Section: Discussionmentioning

confidence: 99%

A Preliminary Assessment of the Utility of Large-Caliber Processed Nerve Allografts for the Repair of Upper Extremity Nerve Injuries

Isaacs

Safa²

2016

Hand (New York, N,Y.)

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“…For evaluation of the conduits or cellular therapies of human origin a well‐established model of T‐cell‐deficient Athymic Nude rat is recommended. Genetically created immunodeficiency in the Athymic Nude rats allows for performing safety and efficacy studies of human‐derived therapies prior to testing in the clinical trials …”

Section: Discussionmentioning

confidence: 99%

Anatomic variations of brachial and lumbosacral plexus models in different rat strains

2016

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This study confirmed that nerves' length within rat's brachial and lumbosacral plexus depends on the inter-individual variations within the rat strains rather than on the differences in the peripheral nerve development, which is inherent to the specific rat strain. Correlation between the nerve length and body weight, suggests that bigger rats should be considered for studies requiring access to the long nerves. © 2016 Wiley Periodicals, Inc. Microsurgery 37:327-333, 2017.

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Athymic rat model for studying acellular human allograft

Cited by 2 publications

References 33 publications

A Preliminary Assessment of the Utility of Large-Caliber Processed Nerve Allografts for the Repair of Upper Extremity Nerve Injuries

A Preliminary Assessment of the Utility of Large-Caliber Processed Nerve Allografts for the Repair of Upper Extremity Nerve Injuries

Anatomic variations of brachial and lumbosacral plexus models in different rat strains

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