Athetoid and Choreiform Hyperkinesias Produced by Caudate Lesions in the Cat

Liles, Samuel L.; Davis, George D.

doi:10.1126/science.164.3876.195

Cited by 34 publications

(6 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many of the cats frequently shook their limbs in the air as they walked. Similar choreiform movements have been reported in cats with lesions of the anteroventral caudate nucleus (Liles & Davis, 1969) and in intact cats following dopaminergic stimulation of the rostromedial caudate nucleus (Cools, 1972).…”

Section: Deficits In Locomotionsupporting

confidence: 81%

Role of activation and sensory stimuli in recovery from lateral hypothalamic damage in the cat.

Wolgin

Teitelbaùm²

1978

Journal of Comparative and Physiological Psychology

View full text Add to dashboard Cite

The early stages of recovery from lateral hypothalamic lesions were analyzed in 30 adult cats. In addition to aphagia and adipsia, neurological examination revealed deficits suggestive of deficient endogenous arousal, including somnolence, catalepsy, akinesia, and sensory neglect. Manipulations (tail pinch and injection of amphetamine) that counteracted these deficits also restored feeding. During recovery from aphagia, feeding gradually became activated by sensory stimuli (sight, feel, and smell) associated with food. These data suggest that activation is an important component in the control of normal feeding.

show abstract

Section: Deficits In Locomotionsupporting

confidence: 81%

Role of activation and sensory stimuli in recovery from lateral hypothalamic damage in the cat.

Wolgin

Teitelbaùm²

1978

Journal of Comparative and Physiological Psychology

View full text Add to dashboard Cite

show abstract

“…The caudate nucleus is linked anatomically with the extrapyramidal motor system, and there are numerous reports that interference with caudate function through lesion or stimulation methods impairs basic motor activities (Hansing, Schwartzbaum, & Thompson, 1968;Kitsikis & Rougeul, 1968;Liles & Davis, 1969). It has also been suggested that the caudate nucleus participates in the inhibition of behavior, and the passive avoidance results of Experiment 2 give qualified support to this hypothesis.…”

Section: Discussionmentioning

confidence: 76%

Functional dissociation within the caudate nucleus of rats.

Winocur¹

1974

Journal of Comparative and Physiological Psychology

101

View full text Add to dashboard Cite

In a series of experiments, rats with posteroventral caudate nucleus lesions were impaired, relative to controls, on 1-way, 2-way, and passive avoidance conditioning; anterodorsal caudate lesions interfered only with 2-way and passive avoidance learning. The anterodorsal group was significantly more impaired than the posteroventral group on the 2-way task (Experiment 2), and there were also important differences in passive avoidance learning (Experiment 1). In Experiment 3, enhancement of positive and negative cues in a 2-way avoidance task selectively benefited the anterodorsal group. It was concluded that the caudate nucleus was functionally dissociated with respect to avoidance conditioning. The importance of the caudate nucleus in motor control and spatial orientation was also discussed.

show abstract

“…However, we can at least be certain from our present observations that no particular gustatory cue is required: a wide range of different tastants and even distilled water are able to effectively elicit treading in the first week after a posterior striatal lesion. Choreic movements in response to visual sensory stimuli have been reported in monkeys with corpus striatum lesions (4), but the present report appears to be the first discovery of a reliable and long lasting, stimulus-specific hyperkinesia in a rodent induced by striatal damage ( 10,13,18).…”

Section: Discussionmentioning

confidence: 63%

A triggered hyperkinesia induced in rats by lesions of the corpus striatum

Berridge

Fentress

Treit

1988

Experimental Neurology

View full text Add to dashboard Cite

The role of the corpus striatum (caudate, putamen, and globus pallidus) in movement control has been suggested to involve the modulation of sensory traffic to downstream motor mechanisms. We report that kainic acid lesions of the posterior corpus striatum, which preferentially spare fibers of passage while destroying striatopallidal neurons, produce a stimulus-sensitive movement pattern in rats that has a highly specific sensory trigger. The triggered choreic movement pattern is not a motor pathology per se, nor a response to diffuse states of arousal or stress, but rather is activated specifically in response to oral sensory stimulation. This sensory-specific hyperkinesia may be relevant to certain human sensorimotor pathologies.

show abstract

Athetoid and Choreiform Hyperkinesias Produced by Caudate Lesions in the Cat

Cited by 34 publications

References 5 publications

Role of activation and sensory stimuli in recovery from lateral hypothalamic damage in the cat.

Role of activation and sensory stimuli in recovery from lateral hypothalamic damage in the cat.

Functional dissociation within the caudate nucleus of rats.

A triggered hyperkinesia induced in rats by lesions of the corpus striatum

Contact Info

Product

Resources

About