Atherothrombosis and oxidative stress: the connection and correlation in diabetes

Nwose, Ezekiel Uba; Jelinek, Herbert F.; Richards, Ross S.; Tinley, Paul; Kerr, Philip G.

doi:10.1179/135100009x392458

Cited by 18 publications

(14 citation statements)

References 34 publications

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“…It is therefore involved in coagulation pathways [44] D-Dimer is an indicator of coagulation activity, since it is the product of the enzymatic degradation of fibrin, a process called fibrinolysis [45]. Both increased and decreased levels have so far been reported in diabetes mellitus patients [46]. Our results showed that there is a trend towards elevated C5a and D-Dimer levels in the prediabetic subjects, which indicates that there probably is a slightly increased coagulation activity already in the prediabetic state, leading the way for future cardiovascular complications.…”

Section: Discussionmentioning

confidence: 98%

Inflammation, coagulation, endothelial dysfunction and oxidative stress in prediabetes — Biomarkers as a possible tool for early disease detection for rural screening

Maschirow

Khalaf

Al-Aubaidy

et al. 2015

Clinical Biochemistry

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The small elevation of blood glucose levels in the prediabetic state may have a detectable influence on endothelial function as indicated by changes to 8-OHdG, indicating an increased DNA-damage and homocysteine release from endothelial cells. Increased oxidative stress as indicated by the reduced GSH/GSSG ratio is likely to be the link between the moderate hyperglycaemia in prediabetes and pathological changes in endothelial function, which in the long-term may promote atherogenesis and result in the development of cardiovascular disease. Early detection of prediabetes is essential to avoid diabetes development and the associated complications like cardiovascular disease. The GSH/GSSG ratio and biomarkers like urinary 8-OHdG and plasma homocysteine offer a possible tool for the assessment of prediabetes in prevention screenings.

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Section: Discussionmentioning

confidence: 98%

Inflammation, coagulation, endothelial dysfunction and oxidative stress in prediabetes — Biomarkers as a possible tool for early disease detection for rural screening

Maschirow

Khalaf

Al-Aubaidy

et al. 2015

Clinical Biochemistry

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“…The excessive production of ROS may result in oxidative damage to many large biomolecules, such as lipids, DNA, and proteins [2]. Oxidative stress has been linked with the pathogenesis of many human diseases including alcoholic liver disease, aging, and diabetes [3]. There is growing interest in the use of natural antioxidants for expanding the shelf life of food without the need for synthetic antioxidants, such as butylates hydroxyanisole (BHA), butylated hydroxytoluene (BHT), and tertiary butyl hydroquinone (TBHQ).…”

Section: Introductionmentioning

confidence: 99%

Potential antioxidant and anticoagulant capacity of low molecular weight fucoidan fractions extracted from Laminaria japonica

Wang

Zhang

et al. 2010

International Journal of Biological Macromolecules

383

184

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“…The decrease in GSH observed closer to the onset of T2DM is due to the activity of plasminogen activator inhibitor-1 (PAI-1) and thrombin-activated fibrinolysis inhibitor (TAFI), followed by an increase in erythrocyte GSH levels associated with erythrocyte oxidative stress [23,24,27]. However, during T2DM disease progression, the physiological response to GSH synthesis/ regeneration is overwhelmed by continued oxidative stress due to free radical activity, which leads eventually to a decrease in GSH concentration and an increase in D-dimer levels [23,27].…”

Section: Introductionmentioning

confidence: 99%

“…D-dimer is a product of fibrin degradation and its level has been related to lower levels of reduced glutathione (GSH) [23,24,27]. An increase in oxidative stress first leads to a depletion in GSH followed by a rebound increase [28].…”

Section: Introductionmentioning

confidence: 99%

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Diabesity Increases Inflammation and Oxidative Stress

A¹,

Pouvreau²,

Eg³

et al. 2016

Int J Pharm Sci Dev Res

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Background: Inflammation and oxidative stress are two pathophysiological mechanisms that link obesity, type 2 diabetes mellitus (T2DM) and diabesity. However how levels of inflammatory and oxidative stress markers differ between patients with obesity, T2DM and diabesity has not been completely elucidated.Objectives: This study aimed to investigate the interactions between emerging biomarkers of oxidative stress and inflammation and the differences in biomarker levels between T2DM, obesity and diabesity in a clinical setting. Methods:A total of 270 patients attending a diabetes health screening clinic (57 T2DM; 37 obese; 44 diabesity, and 132 age, gender, and weight-matched controls) participated in the study. All patients were selected on clinical grounds. Differences in the level of biomarkers of oxidative stress (erythrocyte GSH/GSSG, 8-hydroxy-2-deoxy-guanosine (8-OHdG) and urinary 8-iso-prostaglandin F 2α ), inflammation (CRP, IL-6, IL-10 and IL1β), and coagulation (C5a, D-dimer) were determined.Results: Both inflammatory markers and oxidative stress differed significantly between the three clinical groups. GSH revealed a significant difference between the T2DM (1456.6 µM/mL ± 737.5, p<0.03) and obese groups (1890.7 µM/mL ± 823.3). 8-OHdG increased significantly in the obese group (185.5ng/mL ± 162.4, p<0.03) compared to the control group (146.8ng/mL ± 127.5). Similarly 8-OHdG was significantly higher in the obesity group (185.5ng/mL ± 162.4) compared to the T2DM group (119.2ng/mL ± 92.9, p<0.03). A significant increase was also found for 8-iso-PGF 2α in the diabesity group (2.3 ± 15.0 ng/mL) compared to the control group (1.0 ± 1.9 ng/mL, p<0.03) and the T2DM group (1.1±2.5ng/mL, p<0.05). 8-iso-PGF 2α in the diabesity group (2.3±15.0 ng/mL) was significantly higher than the obese group (1.1ng/mL ±1.8, p<0.03). A significant decrease occurred in IGF-1 levels for diabesity (144.6 ± 285.7 ng/mL) compared to the control (302.8 ± 547.2 ng/mL, p <0.03) and the T2DM groups (225.1ng/mL ± 417, p<0.05). A statistically significant increase in the inflammatory marker ratio IL-6/IL-10 between the control group (0.41 ± 0.7) and the obesity group (0.71 ± 1.94, p<0.03) was also observed. Conclusion:The results obtained indicate that 8-iso-PGF 2α , 8-OHdG as markers of oxidative stress and IGF-1, IL-6/IL-10 are associated with diabesity and could be used diagnostically for risk assessment.markers in obesity [10,11]. The link between inflammatory and oxidative stress markers observed in obesity is also a contributory factor in the development of T2DM and CVD [8,12].The inflammatory process in obesity includes the activation of macrophages to produce pro-inflammatory cytokines such as interleukin-1β (IL-1β) and interleukin-6 (IL-6) [13][14][15]. These proinflammatory cytokines lead to increased levels of C-reactive protein (CRP) with a demonstrable decrease in the anti-inflammatory interleukin-10 (IL-10). IL-1β, IL-6, CRP and IL-10 are linked to abnormal fat and glucose metabolism, which provides further evidence of ...

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Atherothrombosis and oxidative stress: the connection and correlation in diabetes

Abstract: This study provides not only evidence of a correlation between oxidative stress level and fibrinolysis in diabetes, but also an explanation of why previous studies have found both hypo- or hyperfibrinolysis associated with diabetes.

Cited by 18 publications

References 34 publications

Inflammation, coagulation, endothelial dysfunction and oxidative stress in prediabetes — Biomarkers as a possible tool for early disease detection for rural screening

Inflammation, coagulation, endothelial dysfunction and oxidative stress in prediabetes — Biomarkers as a possible tool for early disease detection for rural screening

Potential antioxidant and anticoagulant capacity of low molecular weight fucoidan fractions extracted from Laminaria japonica

Diabesity Increases Inflammation and Oxidative Stress

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