Atherosclerotic Risk Factors in Japanese Subjects With Isolated Impaired Fasting Glucose and Those With Isolated Impaired Glucose Tolerance According to 1997 and 2003 American Diabetes Association Criteria

Impact of lowering the criterion for impaired fasting glucose on identification of individuals with insulin resistance. The GISIR database.

“…Accordingly, the proportion of subjects from the GISIR database quadrupled from 4.1 to 16.5%. This magnitude of increase in the occurrence of IFG is comparable with that previously observed in several different American [3,19,20], European [5], and Asian populations [6,21,22]. Although neither the ADA 2003 nor the ADA 1997 definition of IFG appears to be particularly efficacious in the identification of subjects who have low insulin sensitivity, lowering the value of FPG to 100 mg/dL according to the ADA 2003 recommendations increased the sensitivity without affecting the specificity.…”

“…The impact of lowering the IFG cut-off point in the context of risk association with cardiovascular disease has been the subject of debate. Some studies have suggested that an increased risk for cardiovascular disease is observed with the ADA 2003 cutoff point for IFG [6,22,30]. On the other hand, other prospective and cross-sectional studies failed to show an increased risk for cardiovascular disease in subjects with the ADA 2003 cut-off point for IFG [20,21,31,32].…”

Impact of metabolic indices on central artery stiffness: independent association of insulin resistance and glucose with aortic pulse wave velocity

“…A minimum of 202 (101 per group) participants were required to demonstrate a clinically significant cf PWV difference (>0.8 m/s) between IGR and DM groups at 80% power and (two-tailed) α= 0.05, based on a conservative estimated dependent variable standard deviation of 2.5 [3]. From the data available (using brachial-ankle PWV), 90 (45 per group) participants were required for similar IFG and IGT comparisons (80% power, α=0.05, cf PWV SD=1.5) [37]. Data were analysed using SPSS software (IBM SPSS ver16, Chicago, IL, USA) and assessed using the Kolmogorov-Smirnov test.…”

Metabolic and cardiovascular risk factors in subjects with impaired fasting glucose: the 100 versus 110 mg/dL threshold

“…However, this change has raised discussion and was challenged as to its appropriateness 2–4. A few studies have examined the impact of the ADA 2003 threshold of IFG on metabolic and cardiovascular risk factors as well as the risk for future cardiovascular events 5–9. In this study, we examined whether metabolic and cardiovascular risk factor profile, including inflammatory biomarkers, differ in subjects with the new threshold of IFG (IGF100) as compared with subjects with the old threshold of IFG (IFG110) in a cohort of nondiabetic Italian Caucasians.…”