Atherosclerosis induced by arsenic in drinking water in rats through altering lipid metabolism

Cheng, Tain‐Junn; Chuu, Jiunn-Jye; Chang, Chia Yu; Tsai, Wan‐Chen; Chen, Kuan‐Jung; Guo, How‐Ran

doi:10.1016/j.taap.2011.08.001

Cited by 50 publications

(41 citation statements)

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“…However, prevalence of essential hypertension and diabetes were higher among individuals with positive urine test when compared to others, though the differences were statistically insignificant. The mean duration of residence was 52.6 17.4 yr in the present study which is much higher than similar studies [14][15][16][17][18][19].…”

Section: Discussioncontrasting

confidence: 74%

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Chronic Arsenic Toxicity from Drinking Well Water in a Rural Area

Kazemifar

Mojdehipanah

Arami

et al. 2017

IJT

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Section: Discussioncontrasting

confidence: 74%

“…Association between hypertension and arsenic exposure was dose related [8]. 1.5-fold higher prevalence of hypertension was showed in endemic areas of arsenic exposure [15]. We did not found significant relationship between arsenic exposure and hypertension.…”

Section: Discussioncontrasting

confidence: 58%

Chronic Arsenic Toxicity from Drinking Well Water in a Rural Area

Kazemifar

Mojdehipanah

Arami

et al. 2017

IJT

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“…Similar effects of cadmium on LDL and HDL were observed in a second model of rat exposure that also demonstrated an increase in serum triglycerides [85]. Coupled with a high cholesterol diet, arsenic was shown to promote a pro-atherogenic reduction in the HDL-to-LDL cholesterol ratio without altering total cholesterol or triglyceride levels [86]. In ApoE−/− mice, TCDD exposure was shown to increase LDL levels [79].…”

Section: Diabetes and Cardiovascular Disease In Animal Models Of Edc mentioning

confidence: 82%

Environmental Endocrine Disruption of Energy Metabolism and Cardiovascular Risk

Kirkley

Sargis

2014

Curr Diab Rep

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Rates of metabolic and cardiovascular diseases have increased at an astounding rate in recent decades. While poor diet and physical inactivity are central drivers, these lifestyle changes alone fail to fully account for the magnitude and rapidity of the epidemic. Thus, attention has turned to identifying novel risk factors, including the contribution of environmental endocrine disrupting chemicals. Epidemiological and preclinical data support a role for various contaminants in the pathogenesis of diabetes. In addition to the vascular risk associated with dysglycemia, emerging evidence implicates multiple pollutants in the pathogenesis of atherosclerosis and cardiovascular disease. Reviewed herein are studies linking endocrine disruptors to these key diseases that drive significant individual and societal morbidity and mortality. Identifying chemicals associated with metabolic and cardiovascular disease as well as their mechanisms of action is critical for developing novel treatment strategies and public policy to mitigate the impact of these diseases on human health.

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“…Literature shows that to simulate the cardiovascular effects of natural arsenic exposure through drinking water in the rat model -either normal rat (50 and 100 ppm of sodium arsenite [10,11,38,39] or spontaneous hypertensive rat (100 ppm of arsenic [40]) -different concentrations of arsenic were used. In another recent study, Afolabi et al [41] exposed rats to sodium arsenite (SA) at 50, 100 and 150 ppm for 12 weeks to investigate the association between inorganic arsenic exposure through drinking water and CVDs.…”

Section: Selection Of Arsenic Concentrationmentioning

confidence: 99%