Atherosclerosis in Subhuman Primates

Mr, Malinow

doi:10.1159/000155039

Cited by 14 publications

(1 citation statement)

References 11 publications

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“…The ability to use blood pressure measures as a noninvasive technique to assess health in the marmosets will greatly enhance the ability of researchers to assess homeostatic health in aging marmosets. There is variation in the susceptibility to develop atherosclerosis amongst different non-human primate species (Chamanza, 2011;Clarkson, Lehner, Bullock, Lofland, & Wagner, 1976;Malinow, 1965;Shelton, Clarkson, & Kaplan, 2012;Simmons, 2016). Spontaneous arteriosclerosis, atherosclerosis and arteriopathies in wild and laboratory bred common marmosets are rare and sporadically reported (Bleyer, Kunze, Gruber-Dujardin, & Mätz-Rensing, 2017;Chamanza, 2011;David, Dick Jr, & Hubbard, 2009;Dreizen, Levy, & Bernick, 1973;Shelton et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Cross‐sectional comparison of health‐span phenotypes in young versus geriatric marmosets

Ross

Adams

González

et al. 2019

American J Primatol

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The development of the marmoset as a translational model for healthspan and lifespan studies relies on the characterization of health parameters in young and geriatric marmosets. This crosssectional study examined health phenotypes in marmosets for five domains of interest for human health and aging: mobility, cognition, metabolism, homeostasis, and immune function. Geriatric marmosets were found to have significant executive function impairment when compared to young animals. While geriatric animals did not show gross abnormalities in mobility and measures of locomotion, their types of movement were altered from young animals. Geriatric marmosets had alterations in cardiac function, with significantly increased mean arterial pressures; metabolism, with significantly lower VO 2 ; and suppressed immune function. Further, this study sought to characterize and describe histopathology for both young and geriatric healthy marmosets. Overall this study provides a characterization of health parameters for young and geriatric marmosets which will greatly enhance future aging and interventional testing in marmosets.

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Section: Discussionmentioning

confidence: 99%

Cross‐sectional comparison of health‐span phenotypes in young versus geriatric marmosets

Ross

Adams

González

et al. 2019

American J Primatol

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Social organization and food resource availability in primates: A socio‐bioenergetic analysis of diet and disease hypotheses

Coelho

Bramblett

Quick

1977

American J Phys Anthropol

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Data obtained during a field study of two species of nonhuman primates (Alouatta villosa and Ateles geoffroyi) living in the Tikal National Park in Guatemala are used to suggest an answer to the question: To what extent is the existence of a particular form of social organization (group size, structure, and composition) an indication of the amount of energy in the form of food resources available to animals in a particular habitat? Seven researchers working in teams spent 2,318 hours in the field, 1,145 hours of which were in contact with the monkeys. Comparisons of dietary data, estimated energy expenditures, and habitat productivity provide indications of the degree to which a habitat is capable of supporting the energy and other nutritional requirements of howler and spider monkeys living within the study area. These data suggest that much larger populations and different forms of social organizations can be supported by resources available within the habitat.

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