Atherosclerosis and trimethylamine-N-oxide — the gut microbiota potential

Григорьева, И. Н.

doi:10.15829/1560-4071-2022-5038

Cited by 3 publications

(2 citation statements)

References 57 publications

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“…Отдельно исследовали взаимосвязь между клинико-лабораторными показателями, ЭхоКГ параметрами и ТМА-продуцирующими родами КМ при СНнФВ. Бактерии в кишечнике человека обладают триметиламинлиазной системой (CutC/D) и карнитиновой системой оксигеназы/редуктазы типа Rieske (CntA/B и YeaW/X) для метаболизма холина и карнитина из рациона в ТМА [16,17]. Мы проанализировали взаимосвязи 102 родов в составе КМ, несущих гены различных ТМА-лиаз, с клиниколабораторными показателями и данными ЭхоКГ у пациентов с КБС и СНнФВ.…”

Section: кардиоваскулярная терапия и профилактика 2023;22unclassified

“…На сегодняшний день имеются неоднозначные данные о представителях КМ, способных к конверсии различных субстратов в ТМА [16]. Несмотря на наличие у рода Bacteroides кластера генов cutC/D [17], в исследовании in vitro получены доказательства того, что представители рода Bacteroides не способны продуцировать ТМА [18].…”

Section: кардиоваскулярная терапия и профилактика 2023;22unclassified

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Gut microbiota at different stages of cardiovascular disease continuum

Yafarova,

Dementyeva,

Zlobovskaya

et al. 2024

Cardiovasc Ther Prev

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Aim. To study the relationship of gut microbiota (GM) composition with clinical and paraclinical characteristics of patients with coronary artery disease (CAD) and heart failure with reduced ejection fraction (HFrEF).Material and methods. The study included 64 patients (men, 71,9%) with CAD, 33 (men, 87,9%) with HFrEF and 38 (men, 63,2%) with various cardiovascular risk factors (control group). GM composition was assessed using real-time polymerase chain reaction and next- generation sequencing. To identify correlations of GM composition with clinical and paraclinical characteristics, the Spearman rank correlation coefficient (ρ) was calculated. Generalized linear models (QuasiPoisson, overdispersion) with covariates (age, body mass index) were used to compare groups by phylotype.Results. The relative abundance of Bacillota phylotypes is significantly higher in patients with CAD and HFrEF compared to controls (p<0,001). The Bacillota/Bacteroidota dysbiosis ratio was also significantly higher in patients with CAD and HFrEF than in the control group (p<0,001). According to correlation analysis, the relative representation of methanogenic archaea Methanomassiliicoccaceae, Methanomethylophilaceae (ρ=0,49, p<0,0003) directly correlated with ventricular arrhythmias in patients with HFrEF.Conclusion. Patients with CAD and HFrEF differ significantly from the control group in GM composition at the phylotype level. In the study groups, Bacillota/Bacteroidota dysbiosis ratio was also significantly higher than in the control group. The relative abundance of the archaea Methanomassiliicoccaceae and Methanomethylophilaceae is associated with episodes of ventricular tachycardia/ventricular fibrillation.

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Section: кардиоваскулярная терапия и профилактика 2023;22unclassified

Gut microbiota at different stages of cardiovascular disease continuum

Yafarova,

Dementyeva,

Zlobovskaya

et al. 2024

Cardiovasc Ther Prev

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Polymorphisms of the ATP-binding cassette sterol efflux transporter genes g5 and g8 in cardiovascular diseases and type 2 diabetes mellitus

Grigor’eva,

Notova,

Suvorova

et al. 2024

jour

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Mutations with a decrease in the expression and function of the of the ATP-binding cassette genes proteins ABCG5 and ABCG8, as the main sterol efflux transporters, lead to the accumulation of xenosterols in plasma associated with changes in the lipid profile, hyperglycemia and the risk of cardiovascular diseases (CVD) and type 2 diabetes mellitus (DM2). The review presents studies of the role of ABCG5/G8 polymorphisms in CVD and DM2. In several studies, including large–scale ones, the influence of ABCG5/G8 variants (rs4245791, rs41360247 rs4299376, rs11887534, rs7598542, rs78451356, etc.) on the risk of coronary heart disease (CHD) was proved, in others – when confirming the association of the risk of CHD with ABCG5 polymorphism, this status for ABCG8 was denied. Since sterol metabolism disorders observed in individuals with DM2 are probably associated with low insulin sensitivity, many authors confirmed the association of variants rs4299376, rs4148211, rs140231607 and rs6720173 of the ABCG5/G8 with the risk of DM2, but some authors did not find such a connection with DM2 for variants rs4299376, rs11887534 and rs4148217 of the ABCG8. A decrease in ABCG5/G8 mRNA expression was observed in DM2 in experimental animals and in humans; on the contrary, overexpression of ABCG5/G8 in db/db mice restored the sensitivity of the liver to insulin, which led to a decrease in fasting glucose, lipids and improved glucose tolerance. The inconsistency of data on the association of ABCG5/G8 gene polymorphism with the risk of CVD and DM2 may probably be due to inter-population differences, which necessitates further study of the contribution of ABCG5/G8 variants to the risk of these diseases.

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The role of the gut microbiota in the development of coronary artery atherosclerosis

Safiulina,

Morova,

Bicbavova

2024

Scientific Bulletin of the Omsk State Medical University

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Cardiovascular diseases are one of the most common causes of death in the Russian Federation and worldwide. Consistently high statistical values, despite known risk factors, encourage us to look for new aspects of the etiology, pathogenesis and course of this group of diseases. The group of coronary heart disease requires special attention, most of the nosologies of which are diseases associated with atherosclerotic lesions of the coronary arteries. Despite the well-established concept of the pathogenesis of atherosclerosis associated with the response to endothelial damage, there is more and more data on the participation of gut microbiota metabolites in the occurrence and progression of this process, which has formed into the theory of atherogenic microbiome. The main bacterial factors influencing the pathogenesis of atherosclerosis are considered to be such metabolites as trimethylamine-N-oxide, lipopolysaccharide, short-chain fatty acids, and deoxyribonucleic acid. They take part in changes in lipid metabolism and immunological reactivity of the macroorganism, induce low-grade inflammation, which leads to the progression of atherosclerotic lesions of arteries, including coronary arteries. The purpose of this review is to analyze the literature on the role of the gut microbiota in the pathogenesis of coronary artery atherosclerosis, its effect on lipid metabolism, the relationship between changes in the microbiome and the development of atherosclerotic vascular lesions, and features of the atherogenic microbiome. Literature search was carried out in PubMed and Google Scholar systems among full-text articles published in Russian and English until January 2023 for the keywords: atherosclerosis, gut microbiota, cardiovascular diseases.

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Atherosclerosis and trimethylamine-N-oxide — the gut microbiota potential

Cited by 3 publications

References 57 publications

Gut microbiota at different stages of cardiovascular disease continuum

Gut microbiota at different stages of cardiovascular disease continuum

Polymorphisms of the ATP-binding cassette sterol efflux transporter genes g5 and g8 in cardiovascular diseases and type 2 diabetes mellitus

The role of the gut microbiota in the development of coronary artery atherosclerosis

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