Atherosclerosis and multi-organ-associated pathologies

Keeter, W. Coles; Ma, Shelby; Stahr, Natalie; Moriarty, Alina; Galkina, Elena

doi:10.1007/s00281-022-00914-y

Cited by 20 publications

(12 citation statements)

References 101 publications

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“…While thrombotic diseases are often considered non-inflammatory forms of vasculopathy, mechanisms of immune-mediated thrombosis are complex and involve coordinated dysfunction across activated endothelial cells, platelets, and neutrophils. Galkina et al discuss the role of chronic inflammation in atherosclerosis [18]. Giryes et al review the rapidly evolving understanding of vascular involvement in COVID-19 and describe various forms of vasculitis and vasculopathy that can occur in the pulmonary and systemic vasculature in response to a single pathogen [19].…”

Section: Diseases Of Blood Vessels: Immune System Involvement In Vasc...mentioning

confidence: 99%

Diseases of blood vessels: Immune system involvement in vasculitis and vasculopathy

Grayson

Kaplan

2022

Semin Immunopathol

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Section: Diseases Of Blood Vessels: Immune System Involvement In Vasc...mentioning

confidence: 99%

Diseases of blood vessels: Immune system involvement in vasculitis and vasculopathy

Grayson

Kaplan

2022

Semin Immunopathol

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“…At the same time, cardiovascular and cerebrovascular diseases are pathologically based on vascular occlusion caused by atherosclerotic rupture related to blood lipid levels. When abnormal blood rheology occurs, atherosclerosis may involve multiple organs, particularly the heart and brain (Novo et al, 2014;Novo et al, 2019;Keeter et al, 2022). Furthermore, cardiocerebrovascular diseases have the same pathological basis.…”

Section: Introductionmentioning

confidence: 99%

Chinese herbal injection for cardio-cerebrovascular disease: Overview and challenges

et al. 2023

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Cardio-cerebrovascular diseases are the leading cause of death worldwide and there is currently no optimal treatment plan. Chinese herbal medicine injection (CHI) is obtained by combining traditional Chinese medicine (TCM) theory and modern production technology. It retains some characteristics of TCM while adding injection characteristics. CHI has played an important role in the treatment of critical diseases, especially cardio-cerebrovascular diseases, and has shown unique therapeutic advantages. TCMs that promote blood circulation and remove blood stasis, such as Salvia miltiorrhiza, Carthami flos, Panax notoginseng, and Chuanxiong rhizoma, account for a large proportion of CHIs of cardio-cerebrovascular disease. CHI is used to treat cardio-cerebrovascular diseases and has potential pharmacological activities such as anti-platelet aggregation, anti-inflammatory, anti-fibrosis, and anti-apoptosis. However, CHIs have changed the traditional method of administering TCMs, and the drugs directly enter the bloodstream, which may produce new pharmacological effects or adverse reactions. This article summarizes the clinical application, pharmacological effects, and mechanism of action of different varieties of CHIs commonly used in the treatment of cardio-cerebrovascular diseases, analyzes the causes of adverse reactions, and proposes suggestions for rational drug use and pharmaceutical care methods to provide a reference for the rational application of CHIs for cardio-cerebrovascular diseases.

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“…Atherosclerosis, as a widespread condition [ 18 ], is usually diagnosed in the site of a specific lesion only, e.g., the heart in the case of coronary heart disease. There are several invasive and noninvasive techniques to diagnose atherosclerotic plaques.…”

Section: Introductionmentioning

confidence: 99%

Retinal and Choroidal Thinning—A Predictor of Coronary Artery Occlusion?

et al. 2022

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Introduction. Optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) allowed visualization of retina and choroid to nearly the capillary level; however, the relationship between systemic macrovascular status and retinal microvascular changes is not yet known well. Aim. Our purpose was to assess the impact of retinal optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) parameters on prediction of coronary heart disease (CHD) in acute myocardial infarction (MI) and chronic three vessel disease (3VD) groups. Methods. This observational study included 184 patients—26 in 3VD, 76 in MI and 82 in healthy participants groups. Radial scans of the macula and OCTA scans of the central macula (superficial (SCP) and deep (DCP) capillary plexuses) were performed on all participants. All participants underwent coronary angiography. Results. Patients in MI groups showed decreased parafoveal total retinal thickness as well as GCL+ retinal thickness. Outer circle total retinal thickness and GCL+ retinal thickness were lowest in the 3VD group. The MI group had thinner, while 3VD the thinnest, choroid. A decrease in choroidal thickness and vascular density could predict 3VD. Conclusions. A decrease in retinal and choroidal thickness as well as decreased vascular density in the central retinal region may predict coronary artery disease. OCT and OCTA could be a significant, safe, and noninvasive tool for the prediction of coronary artery disease.

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Atherosclerosis and multi-organ-associated pathologies

Cited by 20 publications

References 101 publications

Diseases of blood vessels: Immune system involvement in vasculitis and vasculopathy

Diseases of blood vessels: Immune system involvement in vasculitis and vasculopathy

Chinese herbal injection for cardio-cerebrovascular disease: Overview and challenges

Retinal and Choroidal Thinning—A Predictor of Coronary Artery Occlusion?

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