Atherosclerosis and Its Cerebral Complications in the South African Bantu

Laurie, W.; Woods, J.D.

doi:10.1016/s0140-6736(58)90918-8

Cited by 60 publications

(3 citation statements)

References 3 publications

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“…2 The concensus is that atherosclerosis of the aorta and coronary arteries, together with the associated complications, is less severe in South African Bantu than in white people, while the incidence of cerebrovascular accidents in the Bantu is at least as high if not higher. [3][4][5][6][7][8][9][10][11] In the studies cited the coronary or cerebral arteries were often not included. Likewise, very few of the reports contained studies on infants.…”

Section: Atherosclerosis In Europieans Andmentioning

confidence: 99%

Atherosclerosis in Europeans and Bantu

et al. 1964

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The atherosclerotic "profile" of the aorta, coronary, and cerebral arteries was gauged by the atherosclerotic index method of Gore and Tejada 12 in 540 unselected white and Bantu autopsy cases. The atherosclerotic indices were very low in all cases until about the third decade. Thereafter there was a progressive rise, which was most dramatic in the aorta and coronary arteries of white men. The aorta and coronary arteries of the white subjects were more severely affected than those of the Bantu whereas the cerebral arteries were about equally affected in the two racial groups. The 540 cases included 87 white men, 58 white women, 111 Bantu men, and 85 Bantu women over the age of 25 years. Of the 87 white men 10 had died from coronary occlusion and five from cerebrovascular accidents. Of the 111 Bantu men none died from coronary occlusive disease and seven of cerebrovascular accidents. Five of the 58 white women died at an advanced age from coronary occlusion; seven died from cerebrovascular accidents. None of the Bantu women died from coronary occlusion and seven from cerebrovascular accidents. Severe atherosclerosis was almost invariably present in cases that died from coronary occlusion suggesting that at least in white persons, coronary atherosclerosis directly predisposes to coronary occlusion. In patients who died from cerebrovascular accidents, macroscopically discernible atherosclerosis was not invariably present. It is suggested that the wide difference in the percentage of "coronary deaths" in the two ethnic groups is due to the much greater frequency of severe coronary atherosclerosis in white persons than in the Bantu. The close correlation between the percentage of "cerebral deaths" in white and Bantu subjects, on the other hand, is not merely the result of equal occurrence or equal susceptibility of the cerebral arteries to atherosclerosis in the two racial groups, but is rather the integrated result of one or more of the following factors: (1) the relative weakness of the cerebrovascular walls, (2) the relative common occurrence of cerebral artery aneurysms (congenital aneurysms), (3) such atherosclerosis as may be present, and (4) rise in blood pressure. Atherosclerosis of the cerebral arteries apparently played a somewhat more important role in white persons than in the Bantu.

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Section: Atherosclerosis In Europieans Andmentioning

confidence: 99%

Atherosclerosis in Europeans and Bantu

et al. 1964

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“…1 In the above report, the platelet aggregability was measured by the optical density (OD) method used by Born' and O'Brien. 8 Though the OD method is the most popular method for detecting platelet aggregability, it was not possible to avoid destruction or injury of platelets during the centrifugation procedure required for preparation of platelet-rich plasma as a testing sample. The screen filtration pressure (SFP) method was originated by Swank, 4 who used whole blood to detect platelet aggregation.…”

Section: Introductionmentioning

confidence: 99%

Cerebral atherosclerosis in Uganda.

Owor¹,

Resch²,

Loewenson³

1976

Stroke

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A study of arterial circles of Willis from a series of 715 consecutive autopsies in Ugandan Africans shows that severity of cerebral atherosclerosis increases with age. No significant difference exists between men and women nor among main tribal groups. The severity is less in Ugandan Africans than in United States blacks but is approximately the same in United States Caucasians. However, the Ugandan Africans show a more severe cerebral atherosclerotic involvement than do the Nigerians.

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“…Laurie and Woods (20) made a study of the cerebral complications of atherosclerosis in the Bantu. They found 31 cases of cerebral hemorrhage or thrombosis in 2,000 consecutive necropsies in Bantu patients, (syphilis and diabetes mellitus excluded).…”

Section: Discussionmentioning

confidence: 99%