Atherosclerosis

Schaftenaar, Frank H.; Frodermann, Vanessa; Kuiper, Johan; Lutgens, Esther

doi:10.1097/mol.0000000000000302

Cited by 217 publications

(112 citation statements)

References 76 publications

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“…Visvikis et al recently identified that HLH-30 and its mammalian homolog TFEB is a key transcriptional regulator of the early innate immune response involving antimicrobials and cytoprotective responses (Visvikis et al, 2014). Interestingly, lipoprotein metabolism and the innate immune systems are increasingly recognized as being functionally linked (Schaftenaar et al, 2016). Although not demonstrated in C. elegans, in higher organisms lipoproteins have been shown to be capable of protecting against lipopolysaccharide (LPS)-induced toxicity through their ability to bind LPSs, thereby modulating the overall host response to this bacterial toxin (Barcia and Harris, 2005).…”

Section: Discussionmentioning

confidence: 99%

Multi-omics Analyses of Starvation Responses Reveal a Central Role for Lipoprotein Metabolism in Acute Starvation Survival in C. elegans

et al. 2017

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Starvation causes comprehensive metabolic changes, which are still not fully understood. Here, we used quantitative proteomics and RNA sequencing to examine the temporal starvation responses in wild-type Caenorhabditis elegans and animals lacking the transcription factor HLH-30. Our findings show that starvation alters the abundance of hundreds of proteins and mRNAs in a temporal manner, many of which are involved in central metabolic pathways, including lipoprotein metabolism. We demonstrate that premature death of hlh-30 animals under starvation can be prevented by knockdown of either vit-1 or vit-5, encoding two different lipoproteins. We further show that the size and number of intestinal lipid droplets under starvation are altered in hlh-30 animals, which can be rescued by knockdown of vit-1. Taken together, this indicates that survival of hlh-30 animals under starvation is closely linked to regulation of intestinal lipid stores. We provide the most detailed poly-omic analysis of starvation responses to date, which serves as a resource for further mechanistic studies of starvation.

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Section: Discussionmentioning

confidence: 99%

Multi-omics Analyses of Starvation Responses Reveal a Central Role for Lipoprotein Metabolism in Acute Starvation Survival in C. elegans

et al. 2017

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“…Hyperlipidemia, a major MetS feature, induces inflammation and plays a fundamental role in atherosclerosis development [ 19 ]. This dyslipidemia is also associated with structural modifications in the native LDL that are currently recognized as a prerequisite for the initiation of lipid accumulation in the arterial intima [ 45 ].…”

Section: Lrp1 In the Metabolic Syndromementioning

confidence: 99%

“…In glucose homeostasis, LRP1 has a regulatory action on the insulin receptor (IR) and GLUT4 activation [ 10 , 16 , 18 ], which has been strongly associated with insulin resistance developed during MetS. In addition, inflammatory processes induced during MetS are also involved in the development of atherosclerosis [ 19 ]. In this case, LRP1 is a molecular and cellular mediator for M2 to M1 macrophage transformation and production of proinflammatory factors that occur in the development of atherosclerotic lesions [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of Low-Density Lipoprotein Receptor-Related Protein 1 in Lipid Metabolism, Glucose Homeostasis and Inflammation

Dato

Chiabrando

2018

IJMS

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Metabolic syndrome (MetS) is a highly prevalent disorder which can be used to identify individuals with a higher risk for cardiovascular disease and type 2 diabetes. This metabolic syndrome is characterized by a combination of physiological, metabolic, and molecular alterations such as insulin resistance, dyslipidemia, and central obesity. The low-density lipoprotein receptor-related protein 1 (LRP1—A member of the LDL receptor family) is an endocytic and signaling receptor that is expressed in several tissues. It is involved in the clearance of chylomicron remnants from circulation, and has been demonstrated to play a key role in the lipid metabolism at the hepatic level. Recent studies have shown that LRP1 is involved in insulin receptor (IR) trafficking and intracellular signaling activity, which have an impact on the regulation of glucose homeostasis in adipocytes, muscle cells, and brain. In addition, LRP1 has the potential to inhibit or sustain inflammation in macrophages, depending on its cellular expression, as well as the presence of particular types of ligands in the extracellular microenvironment. In this review, we summarize existing perspectives and the latest innovations concerning the role of tissue-specific LRP1 in lipoprotein and glucose metabolism, and examine its ability to mediate inflammatory processes related to MetS and atherosclerosis.

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“…However, a growing body of evidence suggests that the pathogenesis of atherosclerosis is much more complex than formerly believed. Immune cells and inflammation play a key role in its pathogenesis in conjunction with hyperlipidemia (4). However, how lipids interact with the immune system is largely unknown.…”

mentioning

confidence: 99%

Association of peripheral differential leukocyte counts with dyslipidemia risk in Chinese patients with hypertension: insight from the China Stroke Primary Prevention Trial

Liu

Kong

Wang

et al. 2017

Journal of Lipid Research

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The aim of the present study was to examine the association between peripheral differential leukocyte counts and dyslipidemia in a Chinese hypertensive population. A total of 10,866 patients with hypertension were enrolled for a comprehensive assessment of cardiovascular risk factors using data from the China Stroke Primary Prevention Trial. Plasma lipid levels and total leukocyte, neutrophil, and lymphocyte counts were determined according to standard methods. Peripheral differential leukocyte counts were consistently and positively associated with serum total cholesterol (TC), LDL cholesterol (LDL-C), and TG levels (all P < 0.001 for trend), while inversely associated with HDL cholesterol levels (P < 0.05 for trend). In subsequent analyses where serum lipids were dichotomized (dyslipidemia/normolipidemia), we found that patients in the highest quartile of total leukocyte count (≥7.6 × 109 cells/l) had 1.64 times the risk of high TG [95% confidence interval (CI): 1.46, 1.85], 1.34 times the risk of high TC (95% CI: 1.20, 1.50), and 1.24 times the risk of high LDL-C (95% CI: 1.12, 1.39) compared with their counterparts in the lowest quartile of total leukocyte count. Similar patterns were also observed with neutrophils and lymphocytes. In summary, these findings indicate that elevated differential leukocyte counts are directly associated with serum lipid levels and increased odds of dyslipidemia.

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Atherosclerosis

Abstract: In this review, we will summarize the latest findings on the interactions between lipids and the immune system, and we will discuss the potential consequences of these novel insights for future therapies for atherosclerosis.

Cited by 217 publications

References 76 publications

Multi-omics Analyses of Starvation Responses Reveal a Central Role for Lipoprotein Metabolism in Acute Starvation Survival in C. elegans

Multi-omics Analyses of Starvation Responses Reveal a Central Role for Lipoprotein Metabolism in Acute Starvation Survival in C. elegans

The Role of Low-Density Lipoprotein Receptor-Related Protein 1 in Lipid Metabolism, Glucose Homeostasis and Inflammation

Association of peripheral differential leukocyte counts with dyslipidemia risk in Chinese patients with hypertension: insight from the China Stroke Primary Prevention Trial

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