Athérosclérose

Bonnet, Jacques

doi:10.1016/j.emcaa.2005.09.011

Cited by 1 publication

(2 citation statements)

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“…In addition, the modified LDLs, i.e. glycated or oxidized, become enable to bind to the LR [4,6]. The HDL particles are metabolized in the liver after uptake by a specific receptor SR-B1 (Scavenger Receptor B1) by interacting with ApoA I [19,20].…”

Section: Structures and Composition Of Lipoproteins -Roles Of Apolipo...mentioning

confidence: 99%

“…Apolipoproteins, circulating enzymes and specific receptors are largely implicated in the metabolism and disposal of lipoproteins from blood [1,5]. If one of these components is impaired, dyslipidemia may occur and lead to various lipid deposits in tissues, atherosclerosis and/or cardiovascular diseases in humans [1,5,6]. Except for Intermediate-Density Lipoproteins (IDL) [7], all kinds of lipoproteins with overall same molecular characteristics are found in dogs, cats and horses [8] but surprisingly, primary atherosclerotic dyslipidemia are rarely observed in these domestic animals.…”

Section: Introductionmentioning

confidence: 99%

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"Lipoproteins and Cholesterol Transport in Dogs, Cats and Horses: Particular Feature Compared to Humans (Mini Review)"

Bret¹

2022

BJSTR

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Lipoproteins are large particles of lipids stabilized by apolipoproteins and they transport lipids in the plasma within the body by specific oriented pathways according to the kind of the lipoproteins. Apolipoproteins have structural and functional roles: they serve as recognition molecules for membrane receptors and are essential partners for enzymes (LPL, LCAT and CETP) that are involved in the metabolism and exchange of lipids. The composition of lipoproteins is slightly different between dogs, cats, horses and humans: VLDLs containing the ApoB48 molecule are identified in dogs and horses. The HDL lipoproteins are the major lipoproteins in animals, but the spherical triglyceride-rich HDL particles are virtually absent because the CETP activity is low. By limiting triglyceride exchanges between lipoproteins, these compositional differences impact the prevalence of atherosclerosis in animals in which the vascular lesions occur secondary to other endocrine and metabolic disorders.

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Section: Structures and Composition Of Lipoproteins -Roles Of Apolipo...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%