Atheroprotective action of a modified organoselenium compound: in vitro evidence

Oliveira, Jade de; Straliotto, Marcos Raniel; Mancini, Gianni; Figueiredo, Cláudia P.; Braga, Antônio L.; Teixeira, J. B.; Andreza, F

doi:10.1590/0001-3765201620150760

Cited by 4 publications

(3 citation statements)

References 68 publications

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“…In the present study, bixin and lycopene exhibited a concentration-dependent inhibition of Cu 2+ -induced lipid peroxidation in isolated human LDL by reducing the rate of oxidation. The lag phase is indicative of the inherent resistance of LDL to oxidation and is widely utilized to assess the potential anti-atherogenic properties of compounds [3,29,46].…”

Section: Discussionmentioning

confidence: 99%

Bixin, a New Atheroprotective Carotenoid Candidate, Prevents oxLDL-Induced Cytotoxicity and Mitochondrial Dysfunction in Macrophages: Involvement of the Nrf2 and NF-κB Pathways

Somacal,

Schüler da Silva,

de Oliveira

et al. 2024

Foods

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The accumulation of oxidized low-density lipoprotein (oxLDL) and its toxicity in the arterial wall have been implicated in atherosclerosis. This study aimed to investigate the mechanisms underlying the atheroprotective effect of bixin, a carotenoid obtained from the seeds of the tropical plant Bixa orellana, on Cu2+-induced LDL oxidation and oxLDL-mediated effects in J774A.1 macrophage cells. Bixin’s effects were compared to those of lycopene, a carotenoid widely studied for its cardiovascular protective effects. LDL was isolated from human plasma, incubated with bixin or lycopene (positive control), and subjected to oxidation with CuSO4. Afterward, bixin or lycopene was incubated with J774A.1 macrophage cells and exposed to oxLDL. The levels of ROS, RNS, GSH, nitrite, mitochondrial function, and foam cell formation, as well as the expression of proteins related to the antioxidant and inflammatory status, were evaluated. The effect of bixin in inhibiting in vitro human-isolated LDL oxidation was more potent (5–6-fold) than that of lycopene. Bixin pretreatment reduced the atherogenic signaling triggered by oxLDL in the macrophages, namely the generation of reactive species, disturbance of nitric oxide homeostasis, mitochondrial dysfunction, and foam cell formation. The cytoprotective effects of bixin were accompanied by the upregulation of Nrf2 and the downregulation of the NF-kB pathways. Lycopene showed the same protective effect as bixin, except that it did not prevent mitochondrial dysfunction. The efficient performance of bixin makes it an ideal candidate for further trials as a new nutraceutical compound for the prevention of atherosclerosis.

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Section: Discussionmentioning

confidence: 99%

Bixin, a New Atheroprotective Carotenoid Candidate, Prevents oxLDL-Induced Cytotoxicity and Mitochondrial Dysfunction in Macrophages: Involvement of the Nrf2 and NF-κB Pathways

Somacal,

Schüler da Silva,

de Oliveira

et al. 2024

Foods

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“…Such athero-protective effect was also confirmed for another GPX-mimicking organoselenium compound, HBD, in in vitro experiments on murine macrophages. HBD application protected isolated LDL from Cu 2+ -induced oxidation and decreased the foam cell formation in macrophage culture exposed to oxLDL [52].…”

Section: Reduction Of Foam Cell Formation By Sementioning

confidence: 92%

The Role of Selenium in Atherosclerosis Development, Progression, Prevention and Treatment

et al. 2023

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Selenium is an essential trace element that is essential for various metabolic processes, protection from oxidative stress and proper functioning of the cardiovascular system. Se deficiency has long been associated with multiple cardiovascular diseases, including endemic Keshan’s disease, common heart failure, coronary heart disease, myocardial infarction and atherosclerosis. Through selenoenzymes and selenoproteins, Se is involved in numerous crucial processes, such as redox homeostasis regulation, oxidative stress, calcium flux and thyroid hormone metabolism; an unbalanced Se supply may disrupt these processes. In this review, we focus on the importance of Se in cardiovascular health and provide updated information on the role of Se in specific processes involved in the development and pathogenesis of atherosclerosis (oxidative stress, inflammation, endothelial dysfunction, vascular calcification and vascular cell apoptosis). We also discuss recent randomised trials investigating Se supplementation as a potential therapeutic and preventive agent for atherosclerosis treatment.

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“…In the same paper, the authors also discussed the beneficial effects of selenium in animal models of Parkinson's disease, a severe neurodegenerative disease. Moreover, Oliveira et al (2016) demonstrated that the organoselenium compound HBD is atheroprotective by preventing Cu 2+ -induced oxidation of lowdensity lipoprotein (LDL), the main factor that causes atherosclerosis (Spence 2016). …”

mentioning

confidence: 99%

Potential Therapeutical Compounds and Scientific Performance of Brazilian Researchers

Schuck

2016

An. Acad. Bras. Ciênc.

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This new supplement of issue 88 of the Annals of the Brazilian Academy of Sciences (AABC) gathers both original and review papers from outstanding Brazilian and international researchers. Several of them show compounds acting as protective agents in different diseases, including selenium and selenium-containing compounds. Selenium is an essential nutrient for human metabolism, especially due its antioxidant properties (Maldonado et al. 2012, Liu et al. 2013, Noguchi 2016. In this context, Ellwanger et al. (2016) revisited some biological functions of selenium and the impact of a dysregulation of its levels in the organism. In the same paper, the authors also discussed the beneficial effects of selenium in animal models of Parkinson's disease, a severe neurodegenerative disease. Moreover, Oliveira et al. (2016) demonstrated that the organoselenium compound HBD is atheroprotective by preventing Cu 2+

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Atheroprotective action of a modified organoselenium compound: in vitro evidence

Cited by 4 publications

References 68 publications

Bixin, a New Atheroprotective Carotenoid Candidate, Prevents oxLDL-Induced Cytotoxicity and Mitochondrial Dysfunction in Macrophages: Involvement of the Nrf2 and NF-κB Pathways

Bixin, a New Atheroprotective Carotenoid Candidate, Prevents oxLDL-Induced Cytotoxicity and Mitochondrial Dysfunction in Macrophages: Involvement of the Nrf2 and NF-κB Pathways

The Role of Selenium in Atherosclerosis Development, Progression, Prevention and Treatment

Potential Therapeutical Compounds and Scientific Performance of Brazilian Researchers

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