Atheromatous Embolization

Hoye, Stephen J.; Teitelbaum, Steven L.; Gore, Ira; Warren, Richard

doi:10.1056/nejm195907162610305

Cited by 61 publications

(2 citation statements)

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“…Presumably the gradual onset of claudication is caused by stenotic lesions which progress slowly to produce arterial occlusion. In those with sudden onset, it is possible that large artery atherosclerotic lesions are complicated by thrombosis, intralesional hemorrhage, or atheromatous embolization [4,5]. These complications may precipitate sudden onset of limb ischemia, but allow some patients to show clinical improvement with the development of a collateral circulation, or the clearing or healing of lesions.…”

Section: Discussionmentioning

confidence: 99%

“…In diabetics, digital ischemia may follow local infections or trauma to the digits or feet. Occasionally, microemboli may originate from a mural thrombus associated with atherosclerosis of the aorta and proximal limb arteries [4]. Digital ischemia can occur as a manifestation of systemic immunologic disorders such as scleroderma and arteritis.…”

Section: Discussionmentioning

confidence: 99%

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The natural history of chronic leg ischemia

et al. 1983

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The onset of leg ischemia may be sudden or gradual, occurring over a wide age spectrum and as a result of multiple causes. The clinical outcome is extremely variable, and only about 1 patient in 8 will progress to the stage of ischemic gangrene. Many patients have the capacity to show marked clinical improvement, or to maintain a comfortable life with claudication that is not severely disabling. Of over 2,000 patients referred to a vascular unit, only about 30% required operative intervention. Rigorous conservative measures should be given a trial for at least 3 months in all patients except those whose limbs are severely threatened, since that period of time is necessary to judge the capacity for spontaneous improvement, before the patient is subjected to the invasive technique of aortography. A flow chart of management decisions is suggested for patients with intermittent claudication.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%