Atherogenic profile in preeclampsia

Var, Ahmet; Kusçu, Kemal; Koyuncu, Faik Mümtaz; Uyanık, Sami B.; Onur, Ece; Yıldırım, Yasemin; Oruç, Semra

doi:10.1007/s00404-002-0317-4

Cited by 28 publications

(17 citation statements)

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“…Our results are in accordance with other previous reports. 10,15,16 To our knowledge, the present study is the largest among those showing no relationship between Lp(a) and pre-eclampsia. Lipoprotein(a) levels were also investigated in women with a history of pre-eclampsia.…”

Section: Discussionmentioning

confidence: 62%

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Lipoprotein(a) levels in women with pre‐eclampsia and in normotensive pregnant women

Baksu¹,

Baksu²,

Davas³

et al. 2005

J of Obstet and Gynaecol

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Section: Discussionmentioning

confidence: 62%

“…3 However, whether plasma levels of Lp(a) change in pre-eclampsia or not, has yet to be clarified. [10][11][12][13][14][15][16]…”

Section: Introductionmentioning

confidence: 99%

Lipoprotein(a) levels in women with pre‐eclampsia and in normotensive pregnant women

Baksu¹,

Baksu²,

Davas³

et al. 2005

J of Obstet and Gynaecol

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“…17,18 For example, pre-eclampsia is associated with a superimposed dyslipidaemia compared with normal pregnancy. [29][30][31] Recent studies demonstrated that elevated levels of oxLDL increase BBB permeability and may be an important contributor to vasogenic brain oedema in severe early-onset pre-eclampsia. 17,32 Our results suggest that antepartum eclampsia occurs more often in early-onset pre-eclampsia; however, they do not indicate that eclamptic women already had an underlying metabolic disorder.…”

Section: Discussionmentioning

confidence: 99%

Formerly eclamptic women have lower nonpregnant blood pressure compared with formerly pre‐eclamptic women: a retrospective cohort study

Schreurs

Cipolla

Al‐Nasiry

et al. 2015

BJOG

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Objective To compare nonpregnant blood pressure and circulating metabolic factors between formerly preeclamptic women who did and did not deteriorate to eclampsia. Design Retrospective observational cohort study. Setting Tertiary referral centre. Population Formerly preeclamptic women with (n=88) and without superimposed eclampsia (n=698). Methods Women who experienced preeclampsia with or without superimposed eclampsia during their pregnancy or puerperium were tested for possible underlying cardiovascular risk factors at least 6 months postpartum. We measured blood pressure and determined cardiovascular and metabolic risk markers in a fasting blood sample. Groups were compared using Mann-Whitney U test, Spearman’s Rho test or Fisher’s Exact test (odds ratios). Main outcome measures Differences in postpartum blood pressures and features of the metabolic syndrome between formerly preeclamptic and formerly eclamptic women. Results Formerly preeclamptic women who developed eclampsia differed from their counterparts without eclampsia by a lower blood pressure (p <0.01) with blood pressure correlating inversely with the likelihood of having experienced eclampsia (p <0.001). In addition, formerly eclamptic women had higher circulating C-reactive protein levels than formerly preeclamptic women (p <0.05). All other circulating metabolic factors were comparable. Finally, 40% of all eclamptic cases occurred in the puerperium. Conclusions Formerly preeclamptic women with superimposed eclampsia have lower nonpregnant blood pressure compared to their counterparts without neurological sequellae with blood pressure negatively correlated to the occurrence of eclampsia. As about 40% of all eclamptic cases occur postpartum, routine blood pressure monitoring postpartum should be intensified. Tweetable abstract Formerly preeclamptics’ nonpregnant blood pressure is negatively correlated to the occurrence of eclampsia.

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“…This method is one of the most widely used assays to assess peroxidation in the whole organism. The reaction of peroxynitrite with lipids leads to peroxidation and MDA and conjugated diene formation [79]. It is noteworthy also that MDA products may behave as toxic bifunctional electrophiles, due to reactivity with proteins, phospholipids, and DNA, generating stable products at the end of a series of reactions to form propane adducts [80].…”

Section: Biomarkersmentioning

confidence: 99%

Oxidative Stress-Related Biomarkers in Essential Hypertension and Ischemia-Reperfusion Myocardial Damage

et al. 2013

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Cardiovascular diseases are a leading cause of mortality and morbidity worldwide, with hypertension being a major risk factor. Numerous studies support the contribution of reactive oxygen and nitrogen species in the pathogenesis of hypertension, as well as other pathologies associated with ischemia/reperfusion. However, the validation of oxidative stress-related biomarkers in these settings is still lacking and novel association of these biomarkers and other biomarkers such as endothelial progenitor cells, endothelial microparticles, and ischemia modified albumin, is just emerging. Oxidative stress has been suggested as a pathogenic factor and therapeutic target in early stages of essential hypertension. Systolic and diastolic blood pressure correlated positively with plasma F2-isoprostane levels and negatively with total antioxidant capacity of plasma in hypertensive and normotensive patients. Cardiac surgery with extracorporeal circulation causes an ischemia/reperfusion event associated with increased lipid peroxidation and protein carbonylation, two biomarkers associated with oxidative damage of cardiac tissue. An enhancement of the antioxidant defense system should contribute to ameliorating functional and structural abnormalities derived from this metabolic impairment. However, data have to be validated with the analysis of the appropriate oxidative stress and/or nitrosative stress biomarkers.

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Atherogenic profile in preeclampsia

Cited by 28 publications

References 0 publications

Lipoprotein(a) levels in women with pre‐eclampsia and in normotensive pregnant women

Lipoprotein(a) levels in women with pre‐eclampsia and in normotensive pregnant women

Formerly eclamptic women have lower nonpregnant blood pressure compared with formerly pre‐eclamptic women: a retrospective cohort study

Oxidative Stress-Related Biomarkers in Essential Hypertension and Ischemia-Reperfusion Myocardial Damage

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